Jianmin Wu

Itaconate delays type 2 diabetes progression by alkylating RIPK3 to inhibit pancreatic β‑cell failure

Xiaoqian Ma, Jianmin Wu, Xingshi Gu, Wen Liu et autres

cn (code pays fourni par la source)

Digitalization of wheat mold odor based on controlled volatile release: A large-scale study

Xiaogang Liang, Qiaofen Chen, Qinqin Li, Jinyin Zhang et autres

cn (code pays fourni par la source)

Probiotic-Derived Extracellular Vesicles Mediate the Neuroprotection of Walnut Green Husk Polysaccharide via the 5-HT/AQP1/Wnt Signaling Axis in Hippocampus

Yanrong Yang, Lishan Jiang, Lin Yu, Linjie Lv et autres

cn (code pays fourni par la source)

Dietary supplementation with postbiotics from Bifidobacterium animalis safely enhances multifunctional health in adult beagle dogs

Mengyao Ma, Yuqiang Zhang, Huakai Wang, Weiwei Wang et autres

Introduction Postbiotics are potential functional feed additives, but their effects on multiple health parameters in dogs remain largely unexplored. Methods This study evaluated postbiotics from Bifidobacterium animalis in adult beagle dogs fed a basal diet supplemented with 0% (CONT), 0.05% (LDP), or …

cn (code pays fourni par la source)

Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance

Fang Wu, Ming Zhang, Jianmin Wu, Z P Wang et autres

Aging is associated with systemic immune remodeling and disease susceptibility, but its impact on intestinal mucosal immunity, particularly changes in M cells, remains largely unknown. This study aimed to investigate how aging alters intestinal mucosal immune phenotypes, specifically follicle-associated epithelial cells (FAE) …

cn (code pays fourni par la source)

One-stage revision with ligament reconstruction for late-infection combined with patellar dislocation following total knee arthroplasty: A case report

Bin Wang, Jiaxuan Fan, Jianmin Wu

cn (code pays fourni par la source)

Eligibility for adjuvant CDK4/6 inhibitors in HR+/HER2− early breast cancer: insights from a large cohort in central south China

Jianmin Wu, Ziru Zhao, Mengxi Li, Jing Cao et autres

Background: The MonarchE and NATALEE trials have established adjuvant CDK4/6 inhibitors (abemaciclib and ribociclib) as pivotal therapies for high-risk hormone receptor-positive (HR+) early breast cancer (EBC). However, real-world data regarding the populations eligible for these trials remains limited, especially in Asian cohorts, …

cn (code pays fourni par la source)

Butyrate-producing commensal bacteria confers colon immune defense function via enhancing H4K31 Crotonylation of macrophages

Jianmin Wu, Pingting Guo, Minghui Wang, Zhaoyue Men et autres

BACKGROUND: The mechanisms by which microbiota from disease-resistant populations or animals improve intestinal immune defense remain incompletely elucidated. Tibetan pig, a renowned disease-resistant breed, serve as a valuable research subject for the health of humans and economic animals. RESULTS: In this study, …

cn, us (code pays fourni par la source)

S2032 Mirikizumab Long-Term Impact on Bowel Urgency in Crohn’s Disease and Its Association With Clinical and Other Efficacy Outcomes: Results From the VIVID-2 Open-Label Extension Study

Stephan R. Vavricka, David T. Rubin, Jianmin Wu, Guanglei Yu et autres

Introduction: Long-term data on bowel urgency (BU) in Crohn’s disease (CD) are limited, and the associations with other efficacy outcomes are not well studied. Methods: To examine the long-term efficacy of mirikizumab (MIRI) on BU remission and the associations between BU remission …

S2031 Incremental Improvement in Bowel Urgency Was Associated With Improved Patient-Reported Outcomes: Post Hoc Results From LUCENT-1 and -2 Trials

Marla C. Dubinsky, Simon Travis, Jianmin Wu, Baojin Zhu et autres

Introduction: Bowel urgency (BU) is a bothersome symptom experienced by patients with ulcerative colitis (UC) and is associated with high clinical and quality-of-life burdens. Mirikizumab (MIRI), an anti-IL-23 antibody approved for the treatment of moderately-to-severely active UC, significantly reduced BU severity compared …

Qianfan-VL: Domain-Enhanced Universal Vision-Language Models

Daxiang Dong, Mingming Zheng, Dong He Xu, Bairong Zhuang et autres

We present Qianfan-VL, a series of multimodal large language models ranging from 3B to 70B parameters, achieving state-of-the-art performance through innovative domain enhancement techniques. Our approach employs multi-stage progressive training and high-precision data synthesis pipelines, which prove to be critical technologies for …

P37 Impact of mirikizumab induction, maintenance, and long-term treatment on disease clearance in ulcerative colitis: post HOC analysis of LUCENT trials

Jean–Frédéric Colombel, Taku Kobayashi, Jianmin Wu, Baojin Zhu et autres

us, jp, ca, de, gb (code pays fourni par la source)