Stefan Kavanagh

Abstract 5745: Discovery of AZD4956, a potent and selective inhibitor of DNA polymerase theta, a clinical candidate for treatment of HRR-deficient tumors in combination with saruparib

Bernard Barlaam, Josep V. Forment, Lee Mulderrig, de Renty Christelle et autres

gb, sg, nl, kr, us, pl (code pays fourni par la source)

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates

Sara Amberntsson, Alison J. Foster, Bhavik Chouhan, Stephen Wilkinson et autres

au, gb, us (code pays fourni par la source)

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors

Adelphe M. Mfuh, Jeffrey A. Boerth, Gayathri Bommakanti, Christina Chan et autres

us, gb, sg, ch, au, de (code pays fourni par la source)

Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity

Jeffrey A. Boerth, Alex J. Chinn, Marianne Schimpl, Gayathri Bommakanti et autres

us, gb (code pays fourni par la source)

P25-14: Hepatic safety assessment of covalent inhibitor drug candidates

Sara Amberntsson, Bhavik Chouhan, Alison J. Foster, Graeme Smith et autres

se, gb (code pays fourni par la source)

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

James S. Scott, Darren Stead, Bernard Barlaam, J. Breed et autres

gb, us (code pays fourni par la source)

Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology

Frederick W. Goldberg, Jason G. Kettle, Gillian M. Lamont, David Buttar et autres

pl, sg, kr, us, de (code pays fourni par la source)

Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia et autres

gb (code pays fourni par la source)

Data supporting "Enhanced hepatic respiratory capacity and altered lipid metabolism supports metabolic homeostasis during short-term hypoxic stress"

Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia et autres

Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis

Paul McGillan, Neil G. Berry, Gemma L. Nixon, Suet C. Leung et autres

gb (code pays fourni par la source)

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Tom Moss, Amber Balazs, Bernard Barlaam et autres

gb, us (code pays fourni par la source)

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis.

W. David Hong, Farid Benayoud, Gemma L. Nixon, Louise Ford et autres