John E. Connolly

Deep learning representations of human Immune Health for precision immunology

Matthew Lee, Jaesik Kim, Matei Ionita, Michelle McKeague et autres

The human immune system is composed of ~30-50 distinct cell types, each of which can exist in different states of activation or differentiation. Indeed, the mammalian immune system has evolved to sense and respond to infections, cancers, injuries, and changes in tissue …

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Respiratory syncytial virus inhibits type I interferon signaling to maintain HLA-DM expression in CD1c+ dendritic cells

Ong Wy, Richard Anthony Hopkins, Enjun Yang, Novita et autres

Respiratory syncytial virus (RSV) infection often elicits ineffective long-term immune responses due to inefficient immune priming, complicating disease management and vaccine development. Dendritic cells (DCs) are central regulators of antiviral immunity and antigen presentation; yet, the direct impact of RSV on these …

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Females are underrepresented in randomized controlled trials of mechanical circulatory support in cardiogenic shock

John E. Connolly, Anushka Desai, R. Weinstein, Craig Cronin et autres

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Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence

Hadeesha Piyadasa, Benjamin Oberlton, Mikaela Ribi, Ke Xuan Leow et autres

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Enabling access to genetically modified cell therapies through flexible approaches to manufacturing and cost recovery

Mark Stewart, Christopher R. Cabanski, Jeff Allen, John E. Connolly et autres

Genetically modified cell-based therapies hold transformative potential, particularly for patients with rare cancers and ultra-rare diseases. However, progress toward regulatory approval, reimbursement, and broad patient access is often constrained by misaligned regulatory, manufacturing, and financial frameworks that do not reflect the realities …

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Timing of microaxial flow pump in acute myocardial infarction related cardiogenic shock: A national analysis of mortality and complications

John E. Connolly, Rohan Rani, Anum Minhas, Peter Johnston et autres

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Investigating the influence of baseline medications on immune checkpoint inhibitor treatment outcomes for cancer patients 3706

Samantha Stone, Zaki F. Wilmot, Zoe Quandt, Aik Choon Tan et autres

Abstract Description Immune checkpoint inhibitors (ICIs) are first-line treatment options for many cancer patients. However, ICI treatment resistance and risk of immune-mediated toxicities continue to impact therapeutic success. Concomitant medications are increasingly recognized for their immunomodulatory properties, yet interactions within complex cancer …

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TCT-838 Natural History and Outcomes of Early Aortic Valve Replacement versus Conservative Management in Patients with Asymptomatic Severe Aortic Stenosis: A Meta-Analysis

Justin Huang, J. D. Ellis, Dorothy Wang, Emily Joseph et autres

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Abstract A001: nELISA high-throughput protein profiling applied to the RADIOHEAD cohort: insights from the largest plasma proteomics study of patients receiving checkpoint inhibitor therapy

Eric D. Miller, Nathaniel Robichaud, Grant Ongo, Samantha I. Liang et autres

Abstract Background: Proteomics holds great promise for cancer immunotherapy, with intensive efforts being exerted for early disease identification, patients selection, and adverse event prediction. Despite this potential, the high cost and low throughput of existing tools to profile circulating proteins render such …

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Approaches to overcome the current treatment plateau in immunotherapy

Anna Maria Di Giacomo, Renzo Canetta, John E. Connolly, Rom S. Leidner et autres

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Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials

Christopher R. Cabanski, Enjun Yang, Mark Stewart, Jeff Allen et autres

Cell-based gene therapies, including chimeric antigen receptor-T, T-cell receptor-T, and tumor-infiltrating lymphocyte therapies, have transformed the treatment landscape for certain cancers, yet their efficacy in solid tumors remains limited. Next-generation therapies aim to overcome biological barriers, enhance potency and safety, and streamline …

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Changes in Payer Mix Associated With Private Equity Acquisition of Ophthalmology Practices

John E. Connolly, Matthew Guido, Anthony Girard, Robert Tyler Braun et autres

This cross-sectional study examines the changes in payer mix associated with private equity acquisition of opthamology practices in the US.

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