Ivan Nyarko‐Danquah

Targeting MAPK-dependent pathways to modulate reactive astrocyte pathology in neurodegeneration

Iqra Pervaiz, Anna S. Blazier, Ivan Nyarko‐Danquah, Hendrik Wesseling et autres

Reactive astrocytes play a crucial role in the pathogenesis of neurodegenerative diseases; however, the mechanisms underlying glial cell interactions remain poorly understood. Here, we show that human primary astrocytes and iPSC-derived astrocytes in a tri-culture system adopt a reactive state with a …

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Role of Glial Cells in Neurodegenerative Diseases and Metals-Induced Neurotoxicity

Edward Alain B. Pajarillo, Ivan Nyarko‐Danquah, Alexis Digman, Sanghoon Kim et autres

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Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice

Edward Alain B. Pajarillo, Sang Hoon Kim, Alexis Digman, Itunu Ajayi et autres

Chronic exposure to elevated levels of manganese (Mn) may cause a neurological disorder referred to as manganism. The transcription factor REST is dysregulated in several neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. REST upregulated tyrosine hydroxylase and induced protection against …

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Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17β-estradiol afforded protection against this manganese toxicity

Ivan Nyarko‐Danquah, Edward Alain B. Pajarillo, Sang Hoon Kim, Alexis Digman et autres

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Role of Astrocytes in Parkinson’s Disease Associated with Genetic Mutations and Neurotoxicants

Sanghoon Kim, Edward Alain B. Pajarillo, Ivan Nyarko‐Danquah, Michael Aschner et autres

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the aggregation of Lewy bodies in the basal ganglia, resulting in movement impairment referred to as parkinsonism. However, the etiology of PD is not well known, with …

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Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

Edward Alain B. Pajarillo, Ivan Nyarko‐Danquah, Alexis Digman, Harpreet Kaur Multani et autres

occupational or environmental settings causes a neurological disorder known as manganism, resembling the symptoms of Parkinson's disease, such as motor deficits and cognitive impairment. Numerous studies have been conducted to characterize manganese's neurotoxicity mechanisms in search of effective therapeutics, including natural and …

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Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

Edward Alain B. Pajarillo, Ivan Nyarko‐Danquah, Alexis Digman, Cynthia Vied et autres

The transcription factor Yin Yang 1 (YY1) is ubiquitously expressed in mammalian cells, regulating the expression of a variety of genes involved in proliferation, differentiation, and apoptosis in a context-dependent manner. While it is well-established that global YY1 knockout (KO) leads to …

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Deletion of RE1‐silencing transcription factor in striatal astrocytes exacerbates manganese‐induced neurotoxicity in mice

Edward Alain B. Pajarillo, Mark Demayo, Alexis Digman, Ivan Nyarko‐Danquah et autres

Abstract Chronic manganese (Mn) overexposure causes a neurological disorder, referred to as manganism, exhibiting symptoms similar to parkinsonism. Dysfunction of the repressor element‐1 silencing transcription factor (REST) is associated with various neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Mn‐induced neurotoxicity, …

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Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

Edward Alain B. Pajarillo, Alexis Digman, Ivan Nyarko‐Danquah, Deok‐Soo Son et autres

Chronic exposure to high levels of manganese (Mn) leads to manganism, a neurological disorder with similar symptoms to those inherent to Parkinson's disease. However, the underlying mechanisms of this pathological condition have yet to be established. Since the human excitatory amino acid …

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Manganese-induced reactive oxygen species activate IκB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro

Asha Rizor, Edward Alain B. Pajarillo, Ivan Nyarko‐Danquah, Alexis Digman et autres

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Neurotoxicity mechanisms of manganese in the central nervous system

Edward Alain B. Pajarillo, Ivan Nyarko‐Danquah, Getinet Mequanint Adinew, Asha Rizor et autres

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Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms

Ivan Nyarko‐Danquah, Edward Alain B. Pajarillo, Alexis Digman, Karam F. A. Soliman et autres

Manganese (Mn) is an essential trace element, serving as a cofactor for several key enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and mitochondrial superoxide dismutase. However, its chronic overexposure can result in a neurological disorder referred to as manganism, presenting symptoms …

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