Huaxing Meng

Obinutuzumab β for aquaporin-4-positive neuromyelitis optica spectrum disorder: a phase 3 randomized controlled trial

Lei Wu, 顾亮亮, Weihao Fan, Min Wei et autres

Although CD20-directed B cell depletion has long been used in neuromyelitis optica spectrum disorder (NMOSD), high-quality, large-scale, randomized controlled trials remain limited. In this multicenter, randomized, double-blind phase 3 trial, we evaluated obinutuzumab β (MIL62), a novel glycoengineered type II anti-CD20 monoclonal …

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A practical alternative to live cell-based assay for AQP4 and MOG antibody detection

Qi Wang, Fengqian Chen, Y. Tang, Juanjuan Zhang et autres

BACKGROUND: Live cell-based assay (LCBA) is the gold standard for sensitive detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in neuromyelitis optica spectrum disorder (NMOSD) and MOG antibody-associated disorder (MOGAD). However, LCBA is less practical, standardisable and cost-effective than fixed …

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A novel recombinant anti-cluster of differentiation 20 humanized monoclonal antibody (B001) for the treatment of neuromyelitis optica spectrum disorder: a phase 1, multicenter randomized, double-blind trial

Dongmei Jia, Huabing Wang, Wei Jiang, Yi Hao Shen et autres

Introduction B001 is a recombinant humanized anti-CD20 monoclonal antibody targeting CD20+ B cells, that has demonstrated superior B cell depletion and anti-proliferative and cytotoxic effects compared to rituximab in a pre-clinical study. The present phase 1b trial assessed the safety, tolerability, pharmacokinetics, …

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Financial Toxicity in Neuromyelitis Optica Spectrum Disorder: An ABC‐X Mixed‐Methods Study

Bo Wang, Shuchuan Tian, Zhaoxia Wang, Guilian Wang et autres

BACKGROUND: Neuromyelitis Optica Spectrum Disorder (NMOSD), a rare antoimmune condition, is characterized by a high relapse rate, necessitating long-term maintenance therapy even during clinically stable periods. This prolonged treatment regimen imposes a significant financial burden on patients, which may be greater than …

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The nomogram model predicts relapse risk in myelin oligodendrocyte glycoprotein antibody-associated disease: a single-center study

Zhuoran Wang, J. Wang, Xiaomin Pang, JianLi Wang et autres

Background Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disorder of the central nervous system, characterized by seropositive MOG antibodies. MOGAD can present with a monophasic or relapsing course, where repeated relapses may lead to a worse prognosis and increased disability. …

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Ethnic-Specific Thresholds of Cerebrospinal Fluid κ Free Light Chains Enhance Diagnostic Precision for Multiple Sclerosis: A Multicenter Study Across Six Provinces in Central and Western China

Guoxun Zhang, Li Zhao, Han Wang, Jia Guo et autres

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Case report: a case of acute autonomic and sensory neuropathy with fluctuating symptoms and literature review

Mingxuan Yang, Jianli Wang, Xiaofeng Wu, Meini Zhang et autres

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A Simple Score (MOG-AR) to Identify Individuals at High Risk of Relapse After MOGAD Attack

Yun Xu, Huaxing Meng, Moli Fan, Linlin Yin et autres

BACKGROUND AND OBJECTIVES: To identify predictors for relapse in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to develop and validate a simple risk score for predicting relapse. METHODS: In China National Registry of Neuro-Inflammatory Diseases (CNRID), we identified patients with …

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Case report: Hyponatremia is an initial presentation of Neuromyelitis optica spectrum disorder

Huaxing Meng, Jing Wang, Jiaqi Hou, Rui‐Qin Liu et autres

OBJECTIVE: Neuromyelitis optica spectrum disorders (NMOSD) is often misdiagnosed or delayed because of the complex and diverse clinical manifestations, especially the atypical initial presentation. Hyponatremia can be an infrequently isolated initial presentation of NMOSD and is associated with hypothalamus involvement. Awareness of …

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Standardized nursing management of enzyme replacement therapy for late-onset Pompe disease

Shan Tang, Jiachu Ma, Huaxing Meng, Junhong Guo et autres

ABSTRACT: Pompe disease or glycogen storage disease type II is a rare autosomal recessive disorder caused by a deficiency of the lysosomal enzyme a-glucosidase. Although enzyme replacement therapy (ERT) with 2 weekly intervals following was considered an effective treatment for Pompe disease …

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A meta-analysis and systematic review of Leigh syndrome: clinical manifestations, respiratory chain enzyme complex deficiency, and gene mutations

Xueli Chang, Yaxin Wu, Jie Zhou, Huaxing Meng et autres

Leigh syndrome (also called Leigh disease or subacute necrotizing encephalomyelopathy) is a rare inherited neurometabolic disorder, which affects the central nervous system. This meta-study systematically analyzed clinical manifestations, respiratory chain enzyme complex deficiency, and gene mutations.Literature was searched for publications in MEDLINE, …

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Paramyotonia congenita and hypokalemic periodic paralysis in a family with mutation p.R1448H in α-subunit type IV of voltage gated sodium channel gene

Xueqi Pan, Wei Zhang, Xueli Chang, Jing Zhang et autres

Objective Through description of the clinical, electrophysiological, pathological and gene sequencing characteristics of a family diagnosed as paramyotonia congenita and hypokalemic periodic paralysis to broaden the understanding of skeletal muscle channel disease and provide the reference for clinical diagnosis. Methods The clinical …

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