Accès ouvert
2024
article
OpenAlex
Victor Riitho, Roisin Connon, Agnes Gwela, Josephine Namusanje et autres
One-third of people with HIV in sub-Saharan Africa start antiretroviral therapy (ART) with advanced disease. We investigated associations between immune biomarkers and mortality in participants with advanced HIV randomised to cotrimoxazole or enhanced antimicrobial prophylaxis in the Reduction of Early Mortality in …
Kenya, gb, Ouganda, Zimbabwe
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Sarah Pett, Moira Spyer, Lewis Haddow, R Nhema et autres
OBJECTIVES: To assess baseline prevalence of cryptococcal antigen (CrAg) positivity; and its contribution to reductions in all-cause mortality, deaths from cryptococcus and unknown causes, and new cryptococcal disease in the REALITY trial. DESIGN: Retrospective CrAg testing of baseline and week-4 plasma samples …
au, gb, Zimbabwe, Ouganda, Malawi, Kenya
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
JA Thompson, Cissy Kityo, David Dunn, Anne Hoppé et autres
BACKGROUND: Limited viral load (VL) testing in human immunodeficiency virus (HIV) treatment programs in low-income countries often delays detection of treatment failure. The impact of remaining on failing protease inhibitor (PI)-containing regimens is unclear. METHODS: We retrospectively tested VL in 2164 stored …
gb, Ouganda, ca, Zimbabwe, Malawi, es, sg
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Jane Mallewa, Alexander J. Szubert, Peter Mugyenyi, Ennie Chidziva et autres
BACKGROUND: In sub-Saharan Africa, severely immunocompromised HIV-infected individuals have a high risk of mortality during the first few months after starting antiretroviral therapy (ART). We hypothesise that universally providing ready-to-use supplementary food (RUSF) would increase early weight gain, thereby reducing early mortality …
gb, Malawi, Ouganda, Zimbabwe, Kenya, au
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Abraham Siika, Leanne McCabe, Mutsa Bwakura‐Dangarembizi, Cissy Kityo et autres
Background: Severely immunocompromised human immunodeficiency virus (HIV)-infected individuals have high mortality shortly after starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late presenter" phenotypes. Methods: The Reduction of EArly MortaLITY (REALITY) trial enrolled ART-naive adults and children ≥5 years …
Kenya, gb, Zimbabwe, Ouganda, Malawi
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
James Hakim, JA Thompson, Cissy Kityo, Anne Hoppé et autres
BACKGROUND: Millions of HIV-infected people worldwide receive antiretroviral therapy (ART) in programmes using WHO-recommended standardised regimens. Recent WHO guidelines recommend a boosted protease inhibitor plus raltegravir as an alternative second-line combination. We assessed whether this treatment option offers any advantage over the …
Zimbabwe, gb, Ouganda, Malawi, Kenya, Zambie, sg
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Nicholas I. Paton, Leonard Bagenda, Joep J. van Oosterhout, Silvia Bertagnolio et autres
BACKGROUND: Cross-resistance after first-line antiretroviral therapy (ART) failure is expected to impair activity of nucleoside reverse-transcriptase inhibitors (NRTIs) in second-line therapy for patients with HIV, but evidence for the effect of cross-resistance on virological outcomes is limited. We aimed to assess the …
sg, gb, Ouganda, Zimbabwe, Malawi, ch
(code pays fourni par la source)