Yucan Wang

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Ailu Yang, Yucan Wang, Yating Yu, Jing Wu et autres

ABSTRACT Understanding the immunological mechanisms underlying chronic hepatitis B virus (HBV) infection‐induced immune tolerance is critical for developing effective therapeutic strategies, yet the mechanisms by which natural killer (NK)‐cell subsets regulate dendritic cell (DC)‐mediated antiviral immunity during chronic HBV infection remain unclear. …

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Chronic HBV infection impairs the glucose metabolism and effector function of NK cells via HBsAg/IL-15/mTOR axis

Yating Yu, Zixuan Wang, Ailu Yang, Yucan Wang et autres

Natural killer (NK) cell function is impaired in patients with chronic hepatitis B (CHB) infection; however, the underlying mechanisms are not fully understood. Here, we collected the blood samples from healthy donors (HDs) and patients with CHB, and then analyzed the characteristics …

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Pre-existing Anti-AAV9 antibodies in the Chinese healthy and rare disease populations: Implications for gene therapy

Qian Zhao, Shuangqing Yu, Diyi Fu, Zhen Wu et autres

• The seroprevalence of anti-AAV9 NAbs in the Chinese population was 58.7 % (0 y-90 y). • The seroprevalence in adults was higher than in children (75.0 % vs 34.3 %). • The antibody titers (NAbs or TAbs) showed no strong correlation …

cn, us (code pays fourni par la source)

Lymph node-targeted STING agonist nanovaccine against chronic HBV infection

Yifei Hu, Ailu Yang, Hui Li, Rongrong Zhao et autres

Chronic hepatitis B virus (HBV) infection is a global health problem that substantially increases the risk of developing liver disease. The development of a novel strategy to induce anti-HB seroconversion and achieve a long-lasting immune response against chronic HBV infection remains challenging. …

cn (code pays fourni par la source)

Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction

Huajun Zhao, Yating Yu, Yucan Wang, Lianhui Zhao et autres

cn (code pays fourni par la source)