Ingemar T. Ernberg

Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities: Proceedings from a conference organised by the Pontifical Academy of Sciences and the European Academy of Cancer Sciences, held in Vatican City, May 22–23, 2025

Ulrik K. Ringborg, Joachim von Braun, Julio E. Celis, Anton Berns et autres

The cancer problem is expanding, particularly in low- and middle-income countries (LMICs). Preventive measures can reduce the incidence by 40–50%, and cure rates have increased during the past decades in a number of cancers. However, optimizing prevention programmes and increasing cure rates …

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Ulrik K. Ringborg, Joachim von Braun, Julio E. Celis, Anton J. M. Berns et autres

The cancer problem is expanding, particularly in low- and middle-income countries (LMICs). Preventive measures can reduce the incidence by 40-50%, and cure rates have increased during the past decades in a number of cancers. However, optimizing prevention programmes and increasing cure rates …

se, de, va, nl, si, fr, br, us, tw, gb, ie, pt, cn, in, be, hu, Afrique du Sud, ca, es (code pays fourni par la source)

Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst

Lu Pan, Bufu Tang, Xuan Zhang, Paolo Parini et autres

The rapid advancement of multi-omics single-cell technologies has significantly enhanced our ability to investigate complex biological systems at unprecedented resolution. However, many existing analysis tools are complex, requiring substantial coding expertize, which can be a barrier for computationally less competent researchers. To …

se, cn, de, us, it, sg (code pays fourni par la source)

Implementing Personalized Cancer Medicine: Insights from a Qualitative Interview Study

Michele M. Masucci, Pamela Mazzocato, Ingemar T. Ernberg, Mats Brommels

Background: Personalized cancer medicine (PCM) tailors cancer treatments based on individual genetic profiles, enabling more precise and effective therapies. Despite its potential, integrating PCM into clinical practice remains challenging because of organizational and systemic barriers. This study examined the factors influencing PCM …

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Eva Klein (1925–2025)

Maria Grazia Masucci, Ingemar T. Ernberg

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MTSS1: beyond the integration of actin and membrane dynamics

Liudmila V. Matskova, Shixing Zheng, Elena Kashuba, Ingemar T. Ernberg et autres

MTSS1 is a ubiquitously expressed intracellular protein known mainly for its involvement in basic cellular processes, such as the regulation of actin organization and membrane architecture. MTSS1 has attracted much attention for its role as a tumor suppressor, being absent or expressed …

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Differential regulation of heparan sulfate biosynthesis in fibroblasts cocultured with normal vs. cancerous prostate cells

Elvira V. Grigorieva, Anastasia V. Strokotova, Ingemar T. Ernberg, Vladimir I. Kashuba

Heparan sulfate proteoglycans (HSPGs) regulate a wide range of biological activities in both physiological and pathological conditions. Altered expression or deregulated function of HSPGs and their heparan sulfate (HS) chains significantly contribute to carcinogenesis as well and crucially depends on the functioning …

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Cancer Core Europe: Leveraging Institutional Synergies to Advance Oncology Research and Care Globally

F. Javier Carmona, Elena Chavarria, Kate Donoghue, Christina von Gertten et autres

Cancer Core Europe brings together the expertise, resources, and interests of seven leading cancer institutes committed to leveraging collective innovation and collaboration in precision oncology. Through targeted efforts addressing key medical challenges in cancer and partnerships with multiple stakeholders, the consortium seeks …

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Bridging the Divide: A Review on the Implementation of Personalized Cancer Medicine

Michele M. Masucci, Claes Karlsson, Lennart Blomqvist, Ingemar T. Ernberg

The shift towards personalized cancer medicine (PCM) represents a significant transformation in cancer care, emphasizing tailored treatments based on the genetic understanding of cancer at the cellular level. This review draws on recent literature to explore key factors influencing PCM implementation, highlighting …

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Single Cell Atlas: a single-cell multi-omics human cell encyclopedia

Lu Pan, Paolo Parini, Roman Tremmel, Joseph Loscalzo et autres

Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two …

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Genetics of immune response to Epstein-Barr virus: prospects for multiple sclerosis pathogenesis

Jesse Huang, Katarina Tengvall, Izaura Bomfim Lima, Anna Karin Hedström et autres

Epstein-Barr virus (EBV) infection has been advocated as a prerequisite for developing multiple sclerosis (MS) and possibly the propagation of the disease. However, the precise mechanisms for such influences are still unclear. A large-scale study investigating the host genetics of EBV serology …

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Bridging the Divide – a Review on the Implementation of Personalized Cancer Medicine

Michele M. Masucci, Ingemar T. Ernberg, Claes Karlsson, Lennart Blomqvist

The shift towards Personalized Cancer Medicine (PCM) represents a significant transformation in cancer care, emphasizing tailored treatments based on genetic understanding of cancer at the cellular level. This review draws on recent literature to explore key factors influencing PCM implementation, highlighting the …

se (code pays fourni par la source)