Anne Roggy

Mature plasmacytoid dendritic cell proliferations are also associated with T-cell acute lymphoblastic leukemia: towards an expanding range of associated neoplasms

Valentin Pourchet, Xavier Roussel, Sabeha Biichlé, Tony Labaigt et autres

Not available.

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Multicenter Flow Cytometry For Acute Myeloid Leukemia Measurable Residual Disease With LAIP/DfN And CD34+CD38- Leukemic Stem Cell-Enriched Populations

Adriana Pleșa, Florent Dumézy, Stéphanie Mathis, Isabelle Arnoux et autres

fraction. A backbone of CD34/CD38/CD45/CD117 was used, completed by lineage markers for the first tube, LSC-associated markers for the second tube, and monocytic and differentiation markers for the third tube. This panel can be used in 8-, 10-, and 12-color formats and …

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Contribution of a specific panel by flow cytometry for the differential diagnosis of plasmacytoid dendritic cell neoplasms

Florian Renosi, Sabeha Biichlé, Xavier Roussel, Thomas Fournet et autres

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Blastic Plasmocytoid Dendritic Cell Neoplasm With Pseudo‐Lymphoid Morphology Mimicking Lymphoid Malignancy

Romain Ravel‐Chapuis, Gérard Buchonnet, Catherine Boutet, Francine Garnache Ottou et autres

A 60-year-old male presented with spontaneous hematomas and cervical adenopathy. Laboratory workup revealed hemoglobin 12.3 g/dL, platelet 56 × 109/L, and leukocyte 14.7 × 109/L. The automated cell counter (Sysmex XN) reported 9% neutrophils (1.32 × 109/L) and 86% lymphocytes (12.6 × …

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Flow MRD Monitoring Combining Laip/Dfn and CD34+CD38- LSCs Is a Strong Predictor of Outcome in Adult AML Independently of the ELN-2022 Risk: First Results from the Multicentric Acute Leukemia French Intergroup MRD Flow Network

Adriana Pleșa, Stéphanie Mathis, Florent Dumézy, Anne‐Catherine Lhoumeau et autres

Introduction MRD monitoring is recommended for treatment response evaluation in clinical AML trials (ELN-2022 guidelines: Heuser et al, PMID 34724563). Besides molecular biology methods, multiparametric flow cytometry represents the most reliable approach. In this study, we evaluated the impact of flow MRD …

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Combination Chemotherapy in Patients with Newly Diagnosed Blastic Plasmacytoid Dendritic Cell Neoplasms (BPDCN): First Results of a Prospective French Trial (LpDessai)

Éric Deconinck, Bérengère Gruson, Sabeha Biichlé, Anne Roggy et autres

Introduction Blastic plasmacytoid dendritic cell neoplasms (BPDCN) are now well-characterized diseases clearly referenced in the 5 th edition of the World Health Organization (WHO) Classification of Tumors (2022) 1 but treatment remains a real challenge. There is no consensus on the first …

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Les anomalies hématologiques et cytologiques observées au cours de l’ostéopétrose maligne infantile

Sandrine Puyraimond, Anne Roggy, Valérie Mathieu, Fabien Lejarre et autres

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AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network

Adriana Pleșa, Florent Dumézy, Stéphanie Mathis, Anne‐Catherine Lhoumeau et autres

Introduction: MRD follow-up is now mandatory for treatment response evaluation in AML clinical trials (ELN 2017 and 2021 guidelines: Heuser et al,Blood doi:10.1182/blood.2021013626.). Beside to molecular biology methods, multiparameter flow cytometry assay represents the most reliable approach. The aim of this study …

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Rôle du cytologiste pour orienter le diagnostic d’un syndrome VEXAS

Anne Roggy, S. Humbert, Valérie Mathieu, Sandrine Puyraimond et autres

L’observation de vacuoles dans les cellules hématopoïétiques au myélogramme conduit le cytologiste à discuter de leur spécificité et de l’intérêt de les signaler. Ces vacuoles sont décrites dans de nombreuses situations pathologiques réactionnelles et, depuis 2020, elles représentent un argument pour évoquer …

Case Report: Evolution of a Severe Vascular Refractory Form of ECD Requiring Liver Transplantation Correlated With the Change in the Monocyte Subset Analysis

Jérôme Razanamahery, Anne Roggy, Jean‐François Emile, Alexandre Malakhia et autres

Erdheim–Chester disease is a rare histiocytosis characterized by iconic features associated with compatible histology. Most patients have somatic mutations in the MAP-kinase pathway gene, and the mutations occur in CD14+ monocytes. Differentiation of the myeloid lineage plays a central role in the …

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Les comptes rendus d’immunophénotypage : enquête des pratiques & propositions d’harmonisation

Batiste Simonet, Mikaël Roussel, Nicola Matteucci, Richard Veyrat‐Masson et autres

Les immunophénotypages réalisés par cytométrie en flux (CMF), pour le diagnostic des hémopathies malignes et des désordres immunitaires, sont soumis aux exigences de la norme NF EN ISO 15189 portant sur les phases pré-, per- et post- analytiques. Le format des comptes-rendus …

Lymphoblastic T Cells and Mature NK Cells With the Same TCRγ Rearrangement: A Common Origin?

Anne Roggy, Sabeha Biichlé, Christophe Ferrand, Florian Renosi et autres

We report a case of a proliferation of blast cells expressing T antigens, associated with mature NK proliferation, and raises the question of whether the 2 populations identified may derive from a bipotent progenitor maintaining T and NK commitment, or whether they …

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