Nobutaka Iwakuma

A randomized phase III trial of dexamethasone mouthwash to prevent chemotherapy-induced oral mucositis in patients with breast cancer.

Sayaka Kuba, Yasuhiro Hagiwara, 柴田伸弘, Takafumi Sangai et autres

12017 Background: Oral mucositis is a common adverse event in patients undergoing chemotherapy for breast cancer. A previous randomized phase II trial showed that a dexamethasone-based mouthwash significantly reduced the incidence and severity of chemotherapy-induced oral mucositis. The SMASH-BC trial was designed …

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Breast cancer pharmacotherapy and imaging interpretation: pathophysiological perspectives and clinical application

Roka Namoto Matsubayashi, Nobutaka Iwakuma

Modern breast cancer treatment has evolved significantly, integrating advanced imaging techniques and a variety of drug therapies, including endocrine therapy, chemotherapy, molecularly targeted drugs, and immune checkpoint inhibitors. This study discusses the interplay of drug treatments and imaging diagnostics in optimizing patient …

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THE ASSOCIATION BETWEEN MOLECULAR SUBTYPES AND NEUTROPHIL-TO-LYMPHOCYTE RATIO (NLR) OF PERIPHERAL BLOOD IN PATIENTS WITH DE NOVO STAGE IV BREAST CANCER

Rie Sugihara, Uhi Toh, Haruka Hiwaki, Hiromi Oku et autres

A retrospective multi-center cohort study investigating safety of sentinel lymph node biopsy for axillary staging in clinical T3-4c breast cancer

Sayaka Kuba, Yasuaki Sagara, Hiroshi Yano, Shigeto Maeda et autres

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Abstract P5-01-27: The relation between local tumor infiltrated T cells (TILs) and neutrophil-to-lymphocyte ratio (NLR) of peripheral blood in patients with De novo Stage IV breast cancer

Rie Sugihara, Uhi Toh, Hidetaka Watanabe, Shuntaro Matsushima et autres

Abstract Purpose: We investigated whether the relation of tumor infiltrated T cells and neutrophil-to-lymphocyte ratio (NLR) can be a novel predictive factor for the benefit of surgery for de novo stage IV breast cancer (DnIV BC) and if primary tumor resection (PTR)'s …

A Retrospective Multi-Center Cohort Study Investigating Safety of Sentinel Lymph Node Biopsy for Axillary Staging in Clinical T3-4c Breast Cancer

Sayaka Kuba, Yasuaki Sagara, Ph.D Hiroshi Yano, Shigeto Maeda et autres

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Current Issues and Future Prospects of Hereditary Breast and Ovarian Cancer (HBOC) Surveillance through Regional Medical Cooperation Networks in Fukuoka city of Japan

Nobutaka Iwakuma, Mina Okabe, Hidetaka Watanabe, Haruka Hiwaki et autres

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The effective duration of systemic therapy and the neutrophil-to-lymphocyte ratio predict the surgical advantage of primary tumor resection in patients with de novo stage IV breast cancer: a retrospective study

Rie Sugihara, Hidetaka Watanabe, Shuntaro Matsushima, Yuriko Katagiri et autres

BACKGROUND: The primary tumor resection (PTR) of de novo stage IV breast cancer (DnIV BC) is controversial, and previous studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) could be a poor-prognosis factor for BC. We investigated PTR's surgical advantage related to clinical …

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A randomized phase III study evaluating dexamethasone-based mouthwash to prevent chemotherapy-induced stomatitis in patients with breast cancer

Sayaka Kuba, Sakiko Soutome, Yasuhiro Hagiwara, Yuichiro Kikawa et autres

Stomatitis, which is a common side effect of chemotherapy, currently lacks a standardized approach for its prevention. Therefore, this multicenter, randomized, open-label, controlled phase III trial aims to assess the efficacy and safety of a dexamethasone-based mouthwash for preventing chemotherapy-induced stomatitis in …

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321P Sentinel lymph node biopsy in clinical T3-4c breast cancer: A retrospective multicenter cohort study

Yasuaki Sagara, Sayaka Kuba, Shintaro Maeda, Hiroki Yano et autres

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Prognostic value of the 21-Gene Breast Recurrence Score® assay for hormone receptor-positive/human epidermal growth factor 2-negative advanced breast cancer: subanalysis from Japan Breast Cancer Research Group-M07 (FUTURE trial)

Takayuki Iwamoto, Naoki Niikura, Kenichi Watanabe, Takashi Takeshita et autres

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Abstract PO2-06-05: Neutrophil-to-lymphocyte ratio (NLR) Predict the Outcome Significance for Primary Tumor Surgery in Patients with De novo stage Ⅳ Breast Cancer

Rie Sugihara, Uhi Toh, Hidetaka Watanabe, Yuriko Katagiri et autres

Abstract [Background] Although several prospective randomized trials have not shown a statistically significant difference in overall survival(OS),and quality-of-life(QOL) for the primary tumor surgery(PTS) of De novo stageⅣ breast cancer(BC), but more recent studies showed that could prolong OS in selected cases. This …

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