Zheng Zhou

Medium‐Entropy Regulation Enables Phase‐Stable Layered Oxide Cathodes with Reversible Anionic Redox for Sodium‐Ion Batteries

Chen Cheng, Zengqing Zhuo, Qianjie Niu, Weidong Xu et autres

ABSTRACT Layered transition‐metal (TM) oxides with anionic redox reactions are promising cathode candidates for sodium‐ion batteries because of their high theoretical capacity and cost effectiveness, but they still suffer from severe P‐to‐O phase transition, irreversible TM migration, and lattice oxygen release. Herein, …

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Effect of white blood count and absolute monocyte count on kidney function in chronic myelomonocytes leukemia (CMML)

Osama Batayneh, Deevyashali Parekh, Mahmoudreza Moein, Eloho Olojakpoke et autres

Abstract Introduction Kidney injury is a common finding in patients with myeloproliferative neoplasms (MPN) such as CMML. Its etiology is multifactorial. In most cases, leukemia induced kidney injury is related to tumor lysis resulting in increased uric acid, direct leukemia kidney infiltration, …

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DNMT3A and NPM1 co-mutations in Acute Myeloid Leukemia (AML): A genomic landscape study

Osama Batayneh, A. Siegenthaler, Sanjay Rao Gergal Gopalkrishna Rao, Deevyashali Parekh et autres

Abstract Background: Independent genomic alterations (GA) in the DNMT3A and NPM1 genes occur frequently in AML. While NPM1 mutation carries favorable prognosis in AML and has emerged as a target for anti-menin based treatments, co-mutation with DNMT3A, a recognized adverse prognostic factor …

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A retrospective survival outcomes analysis of acute erythroid leukemia patients treated with upfront 7+3 induction chemotherapy versus hypomethylating agents with venetoclax utilizing real-world data

Mohamed Zakee Mohamed Jiffry, Devashish Desai, Bhaskara Madhira, Zheng Zhou

Abstract Background: Acute erythroid leukemia (AEL) is considered a rare and aggressive subtype of acute myeloid leukemia (AML). There is some controversy surrounding the exact nature of AEL as a distinct clinicopathologic entity. Whilst the ICC classification system includes AEL under the …

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A retrospective analysis of outcomes of high-risk myelodysplastic syndrome patients treated with upfront decitabine/cedazuridine versus hypomethylating agents with venetoclax utilizing real-world data

Mohamed Zakee Mohamed Jiffry, Devashish Desai, Myungwoo Nam, Zheng Zhou

Abstract Background: High-risk myelodysplastic syndromes (HR-MDS) carry a poor prognosis, with median overall survival under three years and post-hypomethylating agent (HMA) failure survival as low as 4 to 6 months. HMAs have been the standard of care but yield only ~50% initial …

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NUP98 rearrangements (NUP98r) in Acute Myeloid Leukemia (AML): A genomic landscape study

Osama Batayneh, A. Siegenthaler, Deevyashali Parekh, Mahmoudreza Moein et autres

Abstract Background: Nucleoporin 98 rearrangements (NUP98r) occur in a wide range of hematologic malignancies including AML and have been shown to inhibit differentiation of hematopoietic precursors and to increase self-renewal of hematopoietic progenitor cells, providing a potential mechanism for malignant transformation. NUP98r …

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TCT-1141 Incidence and Outcomes of Transcatheter Heart Valve Deformation in Patients with Severe Aortic Stenosis and a Small Annulus

Xiangming Hu, Haowen Ma, Jie Zhao, Can Wang et autres

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Immunodominant Epitope Patch on the CysR Domain of Phospholipase A2 Receptor 1 Is Targeted by Autoreactive PLA2R1 High-Affinity Memory B Cells Generated Through Somatic Mutations in Membranous Nephropathy

Sara Montagner, Linda Reinhard, Alexandra Lavoisier, Martine Marchant et autres

Background: Membranous Nephropathy (MN) is an autoantibody-mediated disease primarily targeting Phospholipase A2 Receptor1 (PLA2R1) on podocytes. The formation of immune complexes alters the structure and function of podocytes, disrupting the glomerular barrier. This study aims at characterizing the serological and memory cellular …

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Metagenomic Next-Generation Sequencing-Assisted Risk Prediction and Stratification of Infections After Kidney Transplantation: A Case Study of COVID-19

Xin Ye, Chao Li, Zheng Zhou, Jiangnan Yang et autres

Background: During the COVID-19 pandemic, COVID-19 infection has severely damaged the transplanted kidney function and health of kidney transplant patients. This study aims to investigate the clinical characteristics, risk factors and predictors of severe COVID-19 in patients after kidney transplantation. Material and …

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A Comprehensive Genomic Analysis of Nucleophosmin (NPM1) in Acute Myeloid Leukemia

Osama Batayneh, Mahmoudreza Moein, Alexandra Goodman, Devashish Desai et autres

Background/Objectives: This study investigates genomic alterations (GA) between NPM1-mutated (NPM1mut) and wild-type (NPM1wt) acute myeloid leukemia (AML), aiming to better understand the AML genomic profile. NPM1mut AML represents a distinct clinical AML subtype with high relapse rates despite initial responsiveness to chemotherapy. …

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Potential circadian rhythm-related pathogenic genes in coronary artery disease: a Mendelian randomization study

Hongliang Zhang, Zhenyan Zhao, Wence Shi, Guannan Niu et autres

PURPOSE: Coronary artery disease (CAD) is a leading cause of cardiovascular morbidity and mortality worldwide. Recent studies suggest disruptions in circadian rhythms may contribute to CAD, but the underlying mechanisms remain unclear. This study employs summary-data-based Mendelian randomization to explore the roles …

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BAP1 exacerbates inflammatory bowel disease by promoting ferroptosis via SLC7A11 suppression

Xing Chen, Yang Yang, Bingjie Han, Zheng Zhou et autres

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