Katharina Ingel

Closed loop stimulation in patients with chronic heart failure and severe chronotropic incompetence: Responders versus non-responders

Joachim Proff, Béla Merkely, Roland Papp, Corinna Lenz et autres

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Closed loop stimulation in heart failure patients with severe chronotropic incompetence: responder versus non-responders

Joachim Proff, Béla Merkely, Roland Papp, Corinna Lenz et autres

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Biotronik SE & Co. KG Woermannkehre 1 12359 Berlin Background The prevalence of chronotropic incompetence (CI) in heart failure (HF) population is high and negatively impacts prognosis. Rate-adaptive pacing (RAP) …

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Impact of closed loop stimulation on prognostic cardiopulmonary variables in patients with chronic heart failure and severe chronotropic incompetence: a pilot, randomized, crossover study

Joachim Proff, Béla Merkely, Roland Papp, Corinna Lenz et autres

AIMS: Clinical effects of rate-adaptive pacing in heart failure patients with chronotropic incompetence (CI) undergoing cardiac resynchronization therapy (CRT) remain unclear. Closed loop stimulation (CLS) is a new rate-adaptive sensor in CRT devices. We evaluated the effectiveness of CLS in CRT patients …

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Simulation of Recurrent Event Data for Non-Constant Baseline Hazard [R package simrec version 1.0.0]

Katharina Ingel, Antje Jahn‐Eimermacher, Stella Preussler, Federico Marini

simrec: Simulation of Recurrent Event Data for Non-Constant Baseline Hazard

Katharina Ingel, Antje Jahn‐Eimermacher, Stella Preussler, Fédérico Marini

Simulation of recurrent event data for non-constant baseline hazard in the total time model with risk-free intervals and possibly a competing event. Possibility to cut the data to an interim data set. Data can be plotted. Details about the method can be …

A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

Antje Jahn‐Eimermacher, Katharina Ingel, Stella Preussler, Antoni Bayés‐Genís et autres

BACKGROUND: Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first event is commonly applied. There is an ongoing debate on whether multiple …

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Simulating recurrent event data with hazard functions defined on a total time scale

Antje Jahn‐Eimermacher, Katharina Ingel, Ann‐Kathrin Ozga, Stella Preussler et autres

BACKGROUND: In medical studies with recurrent event data a total time scale perspective is often needed to adequately reflect disease mechanisms. This means that the hazard process is defined on the time since some starting point, e.g. the beginning of some disease, …

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Sample‐size calculation and reestimation for a semiparametric analysis of recurrent event data taking robust standard errors into account

Katharina Ingel, Antje Jahn‐Eimermacher

In some clinical trials, the repeated occurrence of the same type of event is of primary interest and the Andersen-Gill model has been proposed to analyze recurrent event data. Existing methods to determine the required sample size for an Andersen-Gill analysis rely …

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Sample size in cluster‐randomized trials with time to event as the primary endpoint

Antje Jahn‐Eimermacher, Katharina Ingel

In cluster-randomized trials, groups of individuals (clusters) are randomized to the treatments or interventions to be compared. In many of those trials, the primary objective is to compare the time for an event to occur between randomized groups, and the shared frailty …

No evidence for a correlation of glutathione S-tranferase polymorphisms and chronic rhinosinusitis

Kai Fruth, Nickala Best, Mohammed Amro, Katharina Ingel et autres

OBJECTIVE: Cellular detoxification mechanisms are mandatory for cellular protection against oxidative stress and reactive oxygen species. One major group of antioxidative active enzymes involved in cellular detoxification are the Glutathione S-Transferases (GST). Multiple subtypes like GSTM1, GSTP1, and GSTT1 and variants of …

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Effectiveness of postoperative radiotherapy in patients with small oral and oropharyngeal squamous cell carcinoma and concomitant ipsilateral singular cervical lymph node metastasis (pN1)

Maximilian Moergel, Philipp Meurer, Katharina Ingel, Thomas Georg Wendt et autres

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Adaptive trial design: A general methodology for censored time to event data

Antje Jahn‐Eimermacher, Katharina Ingel

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