Kyu‐Chang Wang

Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics

Kiwan Kim, Seong-Won Song, Yeongha Jeon, Soyoung Choi et autres

PURPOSE: This single-center, open-label, Phase 1 trial evaluated the safety and tolerability of chimeric antigen receptor (CAR)-T cells targeting interleukin-13 receptor α2 (IL13Rα2) in patients with malignant gliomas. PATIENTS AND METHODS: Adults with World Health Organization Grade 3-4 gliomas, recurrent after standard …

kr, us (code pays fourni par la source)

Descriptive Analysis of Surgically Resected Pure Radiation Necrosis After Radiation Therapy for Brain Metastasis: Clinical Features, MRI Findings, and Outcomes

Rae Hyung Kim, Soojin Jang, Ho‐Shin Gwak, Yun‐Sik Dho et autres

BACKGROUND: Differentiating radiation necrosis (RN) from tumor progression is challenging despite advanced neuroimaging techniques. We collected a consecutive series of surgically resected RN with presumptive diagnosis of recurrent/refractory brain metastasis (BM) after radiation therapy (RT) and performed a descriptive analysis of characteristics …

kr (code pays fourni par la source)

Risk of peripartum cerebrovascular events in women with moyamoya disease: A multicenter cohort study

Hyunjun Cho, Tae Keun Jee, Sang Hyo Lee, Jae Seung Bang et autres

Background: Pregnancy and delivery are known to increase the risk of cerebrovascular events (CVEs) in patients with moyamoya disease (MMD). This study determined the frequency, risk factors, and outcome of CVEs during pregnancy in MMD. Methods: We conducted a multicenter study involving …

kr (code pays fourni par la source)

Fate of Brain metastasis with Cerebrospinal fluid space invasion based on MRI findings: Clinical features and factors affecting progression to overt leptomeningeal metastasis

Yoontae Hong, Ho‐Shin Gwak, Yun‐Sik Dho, Sang-Hoon Shin et autres

kr, Éthiopie (code pays fourni par la source)

Surgical treatment for complex adult lumbosacral lipomas excluding retethered cases: what are the benefits?

Jong Seok Lee, Tae‐Hoon Kim, Joo Whan Kim, Sung Eun Hyun et autres

OBJECTIVE: Although spinal dysraphism is a congenital anomaly, it is also diagnosed and treated in adults. The aim of this study was to analyze the clinical outcomes of adult patients with complex lumbosacral lipomatous malformations (LLMs). METHODS: Patients aged 19 years and …

kr, us, Éthiopie (code pays fourni par la source)

Development of the clinical practice guideline protocol registration program and its pilot application in Korea

Hyun Jung Kim, You Kyoung Lee, Soo Young Kim, Kyu‐Chang Wang et autres

BackgroundIn the case of clinical practice guideline (CPG), the need for the prospective registration of protocols has been proposed several times. However, the registration of CPG protocols is not yet active. The objective of this study was to summarize the experience of …

kr (code pays fourni par la source)

Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis

Soojin Jang, Ho‐Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee et autres

Leptomeningeal metastasis (LM) is a devastating complication of cancer that is difficult to treat. Thus, early diagnosis is essential for LM patients. However, cerebrospinal fluid (CSF) cytology has low sensitivity, and imaging approaches are ineffective. We explored targeted CSF metabolic profiling to …

kr, us (code pays fourni par la source)

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip

John J. Y. Lee, Ran Tao, Zhen You, Parthiv Haldipur et autres

Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% …

us, ca, kr, fr, nl, de, mx, jp, hu, pl, gb (code pays fourni par la source)

Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted metabolomics kit to discriminate leptomeningeal metastasis

Soojin Jang, Ho‐Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee et autres

kr (code pays fourni par la source)

TULIPs decorate the three-dimensional genome of PFA ependymoma

Michael J. Johnston, John J. Y. Lee, Bo Hu, Ana Nikolić et autres

Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed 3D genomes …

ca, kr, us, jp, hu, pl (code pays fourni par la source)

Comparison of the Transcranial Approach and Transsphenoidal Approach Based on the Anatomical Location of Origin in Pediatric Craniopharyngiomas

Hyun Joo Park, Joo Whan Kim, Byung‐Kyu Cho, Kyu‐Chang Wang et autres

kr (code pays fourni par la source)

Caudal Agenesis: Classification Based on the Pathoembryogenesis of the Spinal Cord

Youngbo Shim, Kyung Hyun Kim, Seung‐Ki Kim, Kwanjin Park et autres

BACKGROUND AND OBJECTIVES: Caudal agenesis (CA) is a congenital disease characterized by lower vertebral bone defects. Previous classifications for CA were based on the levels of bony defects or the conus medullaris. We created a new pathoembryogenic classification that takes into account …

kr (code pays fourni par la source)