Stanislav Miertuš

Machine learning-based classification model to distinguish tumor and tumor-free samples using synthetic plasma proteomic dataset.

Sara Feizyab, G Bonetti, Alessandro Macchia, K Donato et autres

Background: Tumor-Specific Peptides (TSPs) and Tumor-associated Overexpressed Proteins (TOPs) are promising biomarkers for cancer diagnosis and monitoring. TSPs arise from somatic mutations unique to tumor cells. Their detection in plasma through mass spectrometry-based proteomics provides a non-invasive alternative to traditional biopsy-based diagnostics. …

it, al, sk (code pays fourni par la source)

Mathematical Model to Assess Mutational Burden in Retinal Dystrophy Patients Negative to Mendelian Genetic Tests and Carriers of Multiple Recessive Variants

Maria Chiara Medori, Alessandro Macchia, Paolo Enrico Maltese, Ján Miertuš et autres

Purpose: Despite advancements in genetic testing, a significant number of patients with retinal dystrophy receive negative test results due to single-allele mutations in genes with autosomal recessive inheritance patterns. This study aimed to address this diagnostic challenge by proposing a preliminary mathematical …

Machine Learning–Based Classification of Active and Latent Phases of Inherited Retinal Dystrophies Using Synthetic Proteomic Data: A Pathway-Based Application Exercise

Alessandro Macchia, Maria Chiara Medori, Ahmad Jainul Abidin, G Bonetti et autres

OBJECTIVES: Inherited retinal dystrophies are characterized by high genetic and phenotypic heterogeneity, and their clinical progression may alternate between latent and active phases. Identifying the onset of the active phase may support earlier intervention for inflammatory retinal degeneration. Plasma proteomics has shown …

it, al, sk, us (code pays fourni par la source)

Investigation of the Molecular Differences in Metabolomic and Proteomic Profiles Between Smokers and Nonsmokers

Renáta Kozáčiková, Dominika Vešelényiová, G Bonetti, Alessandro Macchia et autres

Abstract Introduction Tobacco exposure has been associated with molecular alterations in the oral cavity, including changes related to inflammation and oxidative stress. This study aimed to characterize metabolomic and proteomic differences between young smokers and nonsmokers using a non-invasive buccal swab-based multi-omics …

sk, it (code pays fourni par la source)

Isolation and Purification of Bacterially Produced Polyhydroxyalkanoates: Mechanisms, Limitations, and Current Advances

Ľubomíra Jurečková, Daniela Chmelová, Miroslav Ondrejovič, Stanislav Miertuš

Polyhydroxyalkanoates (PHAs) are microbial polyesters that belong to a group of bioplastics with the potential to replace petroleum-derived plastics. Their main drawback is the high production cost, which puts them at a disadvantage compared to conventional plastics. A significant part of these …

sk (code pays fourni par la source)

GENETIC VARIANTS IN LZTR1, MAP2K1 AND RAF1: INSIGHTS INTO THE ROLE OF RAS-MAPK PATHWAY IN PRIMARY LYMPHEDEMA

I Belanova, Dominika Vešelényiová, V Gelanova, Renáta Kozáčiková et autres

The lymphatic system, a complex physiological network of lymphatic organs and vessels, is essential for maintaining fluid homeostasis. Dysfunction of lymphatic system can lead to lymphedema, a pathology characterized by the accumulation of interstitial fluid in peripheral tissues. This study aimed to …

sk, it (code pays fourni par la source)

Artificial Intelligence and Humanoid Robotics: Bioethical Implications of Replacing Human Agency in Healthcare and beyond

Sara Feizyab, G Bonetti, Maria Chiara Medori, Cecília Micheletti et autres

Abstract The integration of advanced artificial intelligence (AI) and humanoid robotics into healthcare represents a critical evolution in biotechnology with profound societal implications. This review explores the bioethical implications of these technologies, and their potential to displace human agency in life-critical decisions. …

it, us, tr, sk, ie, ca, il, al (code pays fourni par la source)

GENETIC STUDY OF HGF-MET SIGNALING PATHWAY IN PRIMARY LYMPHEDEMA PATIENTS: SUPPORTING EVIDENCE FOR LOSS OF FUNCTION VARIANTS IN HGF

Renáta Kozáčiková, Dominika Vešelényiová, V Gelanova, I Belanova et autres

The lymphatic system is composed of lymphatic vessels that connect lymphatic organs and play a critical role in draining lymph fluid from the intracellular environment. Disruptions in this system can lead to defects in lymphatic development and lymphedema which is characterized by …

it, sk (code pays fourni par la source)

Improved Inhibitors Targeting the Thymidylate Kinase of Multidrug-Resistant Mycobacterium tuberculosis with Favorable Pharmacokinetics

Souleymane Konaté, Koffi N’Guessan Placide Gabin Allangba, Issouf Fofana, Raymond Kre N’Guessan et autres

This study aims to design improved inhibitors targeting the thymidylate kinase (TMK) of Mycobacterium tuberculosis (Mtb), the causative agent of infectious disease tuberculosis that is associated with high morbidity and mortality in developing countries. TMK is an essential enzyme for the synthesis …

Côte d’Ivoire, it, sk, fr (code pays fourni par la source)

Genetic Variants in LZTR1, MAP2K1 and RAF1: Insights into the Role of RAS-MAPK Pathway in Primary Lymphedema.

I Belanova, Dominika Vešelényiová, V Gelanova, Renáta Kozáčiková et autres

(c.1344T>G; p.Ile448Met), which could affect protein activation by phosphorylation. The results of this study highlight the genes involved in the RAS/MAPK signaling pathway as potential diagnostic targets for primary lymphedema.

sk, it (code pays fourni par la source)

Genetic Variants in the Transcription Factor Network: The Impact of FOXC1, NOTCH1, RORC, FOXC2 and SOX18 in Primary Lymphedema.

V Gelanova, Dominika Vešelényiová, Renáta Kozáčiková, I Belanova et autres

in primary lymphedema diagnostic practice.

sk, it, us (code pays fourni par la source)

Promoting International Scientific Cooperation: the Role of Scientific Societies

M. Vráblová, Graziella Bonetti, GARY T. M. HENEHAN, Richard E. Brown et autres

Abstract Scientific collaboration yields many advantages, especially in fields that require interdisciplinary approaches, as it fosters the sharing of knowledge and resources and is essential for the implementation of complex projects. The concept of scientific internationalism emerged around the 1900s, emphasizing that …

cz, it, ie, ca, sk, il, cy, tr, us, fr, al (code pays fourni par la source)