Kazuhiro Nakao

Association of Physiological Discordance Between Fractional Flow Reserve and Nonhyperemic Pressure Ratios With Lipid-Rich Plaque Burden

Hirohiko Aikawa, Kota Murai, Yu Kataoka, Yuriko Nakaoku et autres

Abstract Aims Fractional flow reserve (FFR) and nonhyperemic pressure ratios (NHPRs) frequently yield discordant results in clinical practice, yet the mechanisms underlying this mismatch remain uncertain. Plaque composition has been suggested to influence FFR, raising the possibility that discordance reflects the features …

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Snare-assisted retrieval of a disconnected 2.25-mm rotablator burr with guide-extension counter-support

Naoya Yabumoto, Yasuhide Asaumi, Shintaro Kobayashi, Kazuhiro Nakao et autres

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Lipidic Plaque Features of Polyvascular Disease in Response to Low‐Density Lipoprotein Cholesterol <55 mg/dL: Implication of Circulating Lipoprotein(a) Levels

Aya Katasako, Yu Kataoka, Stephen J. Nicholls, Eri Kiyoshige et autres

BACKGROUND: Patients with polyvascular disease (PolyVD) or atherosclerosis in the coronaries and at least 1 additional arterial bed are at increased risk of subsequent clinical cardiovascular events. While lowering low-density lipoprotein cholesterol (LDL-C) is recommended in the secondary prevention settings, whether PolyVD …

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Sex Differences in Clinical Outcomes After Transcatheter Aortic Valve Implantation ― Insights From a Nationwide Japanese Registry ―

Kentaro Mitsui, Kensuke Takagi, Yu Kataoka, Yoko Sumita et autres

BACKGROUND: Sex differences in outcomes after transcatheter aortic valve implantation (TAVI) for aortic stenosis in Japan have not been fully investigated. METHODS AND RESULTS: increase; 95% confidence interval [CI] 0.77-0.91; P<0.001). Female sex was independently associated with lower risks of in-hospital mortality …

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A ≥20% increase in circulating Lp(a) after the commencement of statins, and subsequent risks of atherosclerotic cardiovascular diseases in patients with coronary artery disease

Shuhei Fujita, Yu Kataoka, Naoto Kuyama, Stephen J. Nicholls et autres

BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent and causal risk factor for atherosclerotic cardiovascular disease. While Lp(a) levels are genetically determined and stable, statins have been shown to increase circulating Lp(a). OBJECTIVE: Whether an increase in Lp(a) following the commencement of statins worsens …

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Cardiovascular Outcomes in Response to Achieved LDL-C Levels After PCI in ACS and CCS

Yu Kataoka, Stephen J. Nicholls, Kausik K. Ray, Aya Katasako-Yabumoto et autres

BACKGROUND: Acute coronary syndrome (ACS) exhibits greater risks of recurrent atherosclerotic cardiovascular disease compared to chronic coronary syndrome (CCS), suggesting the need for more intensified preventive management, including low-density lipoprotein cholesterol (LDL-C) control. However, current guidelines advocate the "same" LDL-C goals in …

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Recurrence of cardiovascular events despite achieving LDL-C <1.4 mmol/L in patients with coronary artery disease

Yu Kataoka, Stephen J. Nicholls, Satoshi Kitahara, Aya Katasako-Yabumoto et autres

BACKGROUND: The European Society of Cardiology guideline recommends lowering low-density lipoprotein cholesterol (LDL-C) to <1.4 mmol/L for the prevention of atherosclerotic cardiovascular disease (ASCVD) in patients with very high-risk. However, despite favorable LDL-C control, atherosclerosis still continues to progress, which eventually causes …

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How coronary plaque morphology affects fractional flow reserve: clinical evidence from intravascular imaging studies

Kota Murai, Yu Kataoka, Satoshi Honda, Masashi Fujino et autres

INTRODUCTION: Fractional flow reserve (FFR) is widely used to assess the functional significance of coronary artery disease (CAD). However, the severity of anatomical stenosis does not always correspond with the extent of myocardial ischemia. This discordance highlights the limitations of angiographic assessment …

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Trends and factors associated with potentially inappropriate medication use in older adults hospitalized for heart failure: A nationwide analysis using the JROAD-DPC database

Kazuhiro Nakao, Kunihiro Nishimura, Toshiaki Shishido, Yoko M. Nakao et autres

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Sex Differences in Polyvascular Disease ― Implications for Lipid-Lowering Management and Cardiovascular Outcomes ―

Aya Katasako-Yabumoto, Yu Kataoka, Eri Kiyoshige, Kunihiro Nishimura et autres

Background: Sex differences exist in atherosclerotic cardiovascular disease, partly due to the anti-atherosclerotic properties of estrogens in women. While polyvascular disease (PolyVD) exhibits worse outcomes, it is unknown whether women have an impact on cardiovascular outcomes of PolyVD. Methods and Results: We …

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Circulating Angiopoietin-Like Protein 3 Level and Plaque Calcification: An Optical Coherence Tomography Imaging Analysis

Yu Kataoka, Kota Murai, Stephen J. Nicholls, Yoshiyuki Tomishima et autres

Background Angiopoietin-like protein 3 (ANGPTL3) regulates lipoprotein metabolism, and its genetic deficiency reduces the risk of ASCVD. However, the association between ANGPTL3 expression and atherosclerotic plaque formation remains unclear. Methods We analyzed 58 patients with CAD (89 non-culprit lesions) who underwent optical …

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Drug-Coated Balloon Versus Newer-Generation Drug-Eluting Stent Following Directional Coronary Atherectomy for Left Main Bifurcation Lesions

Kota Murai, Kensuke Takagi, Fumiyuki Otsuka, Yoshiyuki Tomishima et autres

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