Rodrigo Guabiraba

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

Hicham Sid, Theresa von Heyl, Sabrina Schleibinger, Romina Klinger et autres

Retinoic acid-inducible gene I ( RIG-I ) activates mitochondrial antiviral signaling proteins, initiating the antiviral response. RIG-I and RNF135 , a ubiquitin ligase regulator, are missing in domestic chickens but conserved in mallard ducks. The chickens’ RIG-I loss was long believed to …

de, fr, ru, cz, gb (code pays fourni par la source)

Differentiated short- and long-term impacts of a starter stimbiotic supplementation on gut health in broilers fed wheat and rye-based diets at homeostasis and under Eimeria tenella challenge

Vincent Jonchère, Françoise I. Bussière, Olivier Zemb, V. Khaksar et autres

ABSTRACT The postnatal period, covering roughly the first 10 days post-hatch, is critical for early development of the digestive tract in poultry. This period is characterized by high plasticity of the digestive tract, offering a unique window in which to shape digestive …

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The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents Salmonella colonization

Florent Kempf, Rosanna Drumo, Anne‐Marie Chaussé, Pierrette Menanteau et autres

Super- and low-shedding phenomena have been observed in genetically homogeneous hosts infected by a single bacterial strain. To decipher the mechanisms underlying these phenotypes, we conducted an experiment with chicks infected with Salmonella Enteritidis in a non-sterile isolator, which prevents bacterial transmission …

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Targeting DNA-PK is a highly conserved poxvirus innate immune evasion mechanism

Marisa Oliveira, Paul T. Manna, Damaris Ribeiro-Rodrigues, Thomas Allport et autres

Abstract The sensing of viral nucleic acid by pattern recognition receptors (PRRs) is essential for initiation of a type-I interferon response against infection. Intracellular DNA sensing PRRs are responsible for initiating innate immune responses to poxviruses and other double-stranded DNA viruses. Poxviruses, …

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The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken

Vincent Saint-Martin, Vanaïque Guillory, Mélanie Chollot, Isabelle Fleurot et autres

The gut microbiota exerts profound influence on poultry immunity and metabolism through mechanisms that yet need to be elucidated. Here we used conventional and germ-free chickens to explore the influence of the gut microbiota on transcriptomic and metabolic signatures along the gut-lung …

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Exploration of skin redness and immunoglobulin A as markers of the affective states of hens

Delphine Soulet, Anissa Jahoui, Rodrigo Guabiraba, Léa Lansade et autres

Non-invasive markers of affective states can help understanding animals' perception of situations and improving their welfare. These markers are scarce in avian species. In this study, we investigate the potential relation between alterations in facial skin redness in hens and their corresponding …

fr (code pays fourni par la source)

Differentiated Short- and Long-Term Outcomes of an Early Xylanase-Xylo-Oligosaccharide Supplementation on Gut Health in Broilers Fed Wheat/Rye-Based Diets Diets at Homeostasis and During Eimeria. Tenella Infection

Vincent Jonchère, Françoise I. Bussière, Olivier Zemb, V. Khaksar et autres

fr, gb (code pays fourni par la source)

The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken

Rodrigo Guabiraba, Vincent Saint-Martin, Vanaïque Guillory, Mélanie Chollot et autres

fr, gb (code pays fourni par la source)

Mechanisms of type I interferon production by chicken TLR21

Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Mélanie Chollot et autres

The innate immune response relies on the ability of host cells to rapidly detect and respond to microbial nucleic acids. Toll-like receptors (TLRs), a class of pattern recognition receptors (PRRs), play a fundamental role in distinguishing self from non-self at the molecular …

fr, gb, se (code pays fourni par la source)

Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction

Hicham Sid, Theresa von Heyl, Romina Klinger, Leah Heymelot Nabel et autres

Abstract Retinoic acid-inducible gene I ( RIG-I ) activates mitochondrial antiviral signaling proteins, initiating the antiviral response. RIG-I and RNF135 , a ubiquitin ligase regulator, are missing in domestic chickens but conserved in mallard ducks. The chickens’ RIG-I loss was long believed …

de, fr, cz, gb (code pays fourni par la source)

Mechanisms of type I interferon production by chicken TLR21

Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Mélanie Chollot et autres

Abstract The innate immune response relies on the ability of host cells to rapidly detect and respond to microbial nucleic acids. Toll-like receptors (TLRs), a class of pattern recognition receptors (PRRs), play a fundamental role in distinguishing self from non-self at the …

fr, gb, se (code pays fourni par la source)

The caecal microbiota promotes the acute inflammatory response and the loss of the intestinal barrier integrity during severe Eimeria tenella infection

Florian Tomal, Guillaume Sadrin, Pauline Gaboriaud, Édouard Guitton et autres

Introduction Coccidiosis, a disease caused by intestinal apicomplexan parasites Eimeria, is a threat to poultry production. Eimeria tenella is one of the most pathogenic species, frequently causing a high prevalence of opportunistic infections. Objective The objective of this study is to investigate …

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