Isabel Mejia

ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes

Bing Dai, Adrian W. Sperl, Lucas Polack, Isabel Mejia et autres

Herpesvirales are an ancient viral order that causes lifelong infections in species from mollusks to humans. They export their capsids from the nucleus to the cytoplasm by a noncanonical nuclear egress route that involves capsid budding at the inner nuclear membrane followed …

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Supplementary Table 1 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

MS data of H1792 cells treated with NMTi

Figure S9 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

The PARP inhibitor olaparib rescues death induced by NMTi treatment.

Figure S7 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Treatment with necroptosis and pyroptosis inhibitors fail to prevent cell death induced by of NMTi treatment in lung carcinoma cells.

Figure S5 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Inhibition of NMT increases mitochondrial ferrous iron content in (KL/K)MUT but not (KL/K)WT lung carcinoma cells.

Figure S11 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Effect of NMTi on the abundance of TIM17A in lung carcinoma cells.

Figure S10 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Mitochondria is a key target of NMT inhibitors.

Figure S1 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

NMT1 is a therapeutic target in lung carcinoma

Figure S6 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Inhibition of NMT prevents cell cycle progression and causes death in lung carcinoma cells.

Figure S8 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

NMTi treatment induces features of parthanatos in vitro and in vivo.

Figure S4 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Inhibition of NMT increases mitochondrial ferrous iron content in (KL/K)MUT but not (KL/K)WT lung carcinoma cells.

Figure S12 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Sofia Geroyska, Isabel Mejia, Alfred A. Chan, Marian Navarrete et autres

Effect of lipid peroxidation on the abundance of TIM17A in lung carcinoma cells.