Mimi L. Phan

Daily high doses of atorvastatin alter neuronal morphology in a juvenile songbird model

Shuk C. Tsoi, Alicia C. Barrientos, David S. Vicario, Mimi L. Phan et autres

Statins are highly effective and widely prescribed cholesterol lowering drugs. However, statins cross the blood-brain barrier and decrease neural cholesterol in animal models, raising concern that long-term statin use may impact cholesterol-dependent structures and functions in the brain. Cholesterol is a fundamental …

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Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors

Isabella Maita, Allyson S. Bazer, Kiyeon Chae, Amlaan Parida et autres

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Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors

Isabella Maita, Allyson S. Bazer, Kiyeon Chae, Amlaan Parida et autres

Abstract Corticotropin-releasing factor (CRF) in the anterior bed nucleus of the stria terminalis (aBNST) is associated with chronic stress and avoidance behavior. However, CRF+ BNST neurons project to reward- and motivation-related brain regions, suggesting a potential role in motivated behavior. We used …

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The Direction of response selectivity between conspecific and heterospecific auditory stimuli varies with response metric

Katharine H. Stenstrom, Henning U. Voss, Kirill Tokarev, Mimi L. Phan et autres

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Engrailed 2 deficiency and chronic stress alter avoidance and motivation behaviors

Mimi L. Phan, Tonia T. Liu, Mallory S. Vollbrecht, Mark H. Mansour et autres

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Abstract MP09: Untargeted 1 H Nmr Metabolomics Metabolomic Analysis Reveals Pathways Of Protection Between Mediterranean-style Diet And Incident Cardiovascular Disease In The Multi-ethnic Study Of Atherosclerosis.

Alexis C. Wood, Georgina Saylor, Ioanna Tzoulaki, Philip Greenland et autres

Background: The metabolites associated with a Mediterranean-style (AMED) diet may give insight into why AMED is robustly associated with protection against CVD. Previous investigations seeking to identify these have been limited by the use of modest sample sizes and targeted assays. Methods: …

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Optimizing drug inventory management with a web-based information system: The TBTC Study 31/ACTG A5349 experience

Nigel A. Scott, Kara K. Lee, Claire Sadowski, Ekaterina V. Kurbatova et autres

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Central monitoring in a randomized, open-label, controlled phase 3 clinical trial for a treatment-shortening regimen for pulmonary tuberculosis

Kia Bryant, Melissa Engle, Ekaterina V. Kurbatova, Cynthia Allen-Blige et autres

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Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis

Panting Hu, Isabella Maita, Mimi L. Phan, Edward Gu et autres

Abstract Early-life stress (ELS) leads to stress-related psychopathology in adulthood. Although dysfunction of corticotropin-releasing hormone (CRH) signaling in the bed nucleus of the stria terminalis (BNST) mediates chronic stress-induced maladaptive affective behaviors that are historically associated with mood disorders such as anxiety …

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Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis

Panting Hu, Ji Liu, Isabella Maita, Christopher Kwok et autres

The bed nucleus of the stria terminalis (BNST) is a forebrain region highly responsive to stress that expresses corticotropin-releasing hormone (CRH) and is implicated in mood disorders, such as anxiety. However, the exact mechanism by which chronic stress induces CRH-mediated dysfunction in …

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Influence of early-life nutritional stress on songbird memory formation

Brittany Alicia Bell, Mimi L. Phan, Alizée Meillère, Jessica K. Evans et autres

In birds, vocal learning enables the production of sexually selected complex songs, dialects and song copy matching. But stressful conditions during development have been shown to affect song production and complexity, mediated by changes in neural development. However, to date, no studies …

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Observations of Toddlers’ Sensory-based Exploratory Behaviors with a Novel Food

Shabnam R. Momin, Sheryl O. Hughes, Cindy V. Elias, Maria Papaioannou et autres

Background: Food neophobia hinders the acceptance of healthy food in young children, and may be overcome by repeated food exposure. The prevalent literature states that children exhibit 5 sensory-based exploratory behaviors (SBEBs): smelling, licking, spitting, manipulating and / or swallowing as they …