Liaoxun Lu

A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions

Tianhan Li, Xin Dong, Xinyao Niu, Haoyue Zhang et autres

Atherosclerosis is a chronic vascular inflammatory disease, and mouse models are essential for studying its pathogenesis. The Cre/loxP technology has become the gold standard for cell-type-specific gene targeting. However, the rapid proliferation of Cre driver lines has made model selection increasingly challenging. …

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Vascular Smooth Muscle Cell Plasticity in Atherosclerosis: Mechanisms, Recent Advances, and Therapeutic Implications

Tianhan Li, Xinyao Niu, Liaoxun Lu, Yinming Liang et autres

Atherosclerosis, the fundamental pathological basis of most cardiovascular diseases which remain the leading cause of global mortality, is driven by both lipid accumulation and dynamic cellular reprogramming within the vessel wall. Central to this process is the remarkable phenotypic plasticity of vascular …

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Lipa regulates myeloid differentiation and is essential for intra-plaque macrophage accumulation during atherogenesis

Tianhan Li, Juanjuan Qiu, H Zhang, Jianjun Wu et autres

Lysosomal acid lipase ( LIPA ), one of the earliest and most impactful genetic factors linked to human coronary artery diseases, is highly expressed in macrophages despite predominant hepatic production. However, the functional importance of LIPA in macrophages remained largely unknown. Notably, …

cn, gb, fr (code pays fourni par la source)

PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function

Jia Tong, Y F Liu, Wanliu Wu, Qianqian Wang et autres

Palmitoylation is a reversible lipid modification, regulating protein localization and signaling in neurons. Growth-associated protein 43 (GAP43) requires palmitoylation for axonal development and synaptic plasticity; however, its depalmitoylase and regulation in neural circuits remain unknown. We investigated whether palmitoyl-protein thioesterase 1 (PPT1) …

cn, gb (code pays fourni par la source)

Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes

Ziyin Zhang, Nanshu Xiang, Qian Liu, Yanfeng Li et autres

The development and function of B lymphocytes require the precise integration of signaling, transcriptional networks, and metabolic programs. While interferon (IFN)-inducible proteins can bridge innate and adaptive immunity, their roles in B cells remain poorly defined. Here, we identified RNF213, a giant …

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Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong et autres

cn, fr (code pays fourni par la source)

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong et autres

Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however, the cellular and molecular mechanisms that trigger the inflammatory response in atherosclerotic plaques remain …

cn, fr (code pays fourni par la source)

Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xinyong Dong et autres

Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellular and molecular mechanisms that trigger the inflammatory response in atherosclerotic plaques remain …

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong et autres

Abstract Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellular and molecular mechanisms that trigger the inflammatory response in atherosclerotic …

cn, fr (code pays fourni par la source)

Dock8 regulates Th2 cell differentiation through ANXA1

Ju Liu, Jianing Tang, Zhenzhen Li, Chunrui Wu et autres

Dedicator of Cytokinesis 8 (DOCK8), a member of the DOCK family of guanine nucleotide exchange factors, serves as a key factor in managing the Rho GTPases activity, notably Cdc42 and Rac1, which control key cellular processes, including migration, adhesion, and phagocytosis. Mutations …

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Human myelocyte and metamyelocyte-stage neutrophils suppress tumor immunity and promote cancer progression

Wei Liu, Tao Shi, Chun‐Yi Lu, Keying Che et autres

cn, us (code pays fourni par la source)

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong et autres

Abstract Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellular and molecular mechanisms that trigger the inflammatory response in atherosclerotic …

cn, fr (code pays fourni par la source)