Léa Fortunato

Clinical and Molecular Effect of the Anti– IL ‐18 Antibody Aletekitug in Adults With Atopic Dermatitis

Joanne Ellis, Léa Fortunato, Hannah Wajdner, Ester Del Duca et autres

BACKGROUND: Interleukin-18 (IL-18) is a pleiotropic cytokine implicated in atopic dermatitis (AD), affecting both type (T)1 and T2 immune pathways. An anti-IL-18 monoclonal antibody, aletekitug, was evaluated for its clinical and molecular effects in patients with moderate to severe AD. METHODS: This …

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64631 Patient-Level Clinical Response Rates to GSK1070806, an Anti–IL-18 Monoclonal Antibody, in Moderate-to-Severe Atopic Dermatitis (AD): A Randomized, Double-Blind, Placebo-Controlled Study

John Francis Kelly, Léa Fortunato, J. R. Lowe, Scott M. Dinehart et autres

gb, us (code pays fourni par la source)

678 - Patient-reported outcomes for GSK1070806, an anti-IL-18 monoclonal antibody: a phase 1b, randomised, double-blind, parallel-group placebo-controlled study of patients with atopic dermatitis

Parima Ghafoori, Léa Fortunato, Dharm S. Patel, Joanne Ellis et autres

Abstract Introduction/Background Administration of GSK1070806, an anti–IL-18 monoclonal antibody, in patients with atopic dermatitis (AD) resulted in significant clinical improvements versus placebo after 12 weeks. Objectives Assessment of patient-reported outcomes (PROs) for patients with AD receiving GSK1070806. Methods In this multicentre, randomised, …

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Intradermal substance P as a challenge agent in healthy individuals

Wouter ten Voorde, Chika Akinseye, Ismahaan Abdisalaam, Selinde S. Wind et autres

Abstract Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with wheal and flare response mediated by the MRGPRX2 receptor. Although dose‐dependent …

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Depletion of LAG‐3 + T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781

Joanne Ellis, Daniel JB Marks, Naren Srinivasan, Christine Barrett et autres

Activated T cells drive a range of immune‐mediated inflammatory diseases. LAG‐3 is transiently expressed on recently activated CD4 + and CD8 + T cells. We describe the engineering and first‐in‐human clinical study (NCT02195349) of GSK2831781 (an afucosylated humanized IgG1 monoclonal antibody enhanced …

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Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study

Joanne Ellis, André van Maurik, Léa Fortunato, Sophie Gisbert et autres

Aim Interleukin (IL)‐7 signalling modulates T cell activity and is implicated in numerous autoimmune diseases. The present study investigated the safety, pharmacokinetics, target engagement, pharmacodynamics and immunogenicity of GSK2618960, an IL‐7 receptor‐α subunit (CD127) monoclonal antibody. Methods A double‐blind (sponsor‐unblind) study of …

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Associations between urban metrics and mortality rates in England

Daniela Fecht, Léa Fortunato, David W. Morley, Anna Hansell et autres

BACKGROUND: Seventy-five percent of the population in Europe live in urban areas and analysing the effects of urban form on the health of the urban population is of great public health interest. Not much is known, however, on the effects of urban …

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A century of trends in adult human height

James Bentham, Mariachiara Di Cesare, Gretchen A. Stevens, Bin Zhou et autres

10.7554/eLife.13410.001

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Stomach cancer and occupational exposure to asbestos: a meta-analysis of occupational cohort studies

Léa Fortunato, Lesley Rushton

BACKGROUND: A recent Monographs Working Group of the International Agency for Research on Cancer concluded that there is limited evidence for a causal association between exposure to asbestos and stomach cancer. METHODS: We performed a meta-analysis to quantitatively evaluate this association. Random …

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Geographical and socioeconomic inequalities in women and children's nutritional status in Pakistan in 2011: an analysis of data from a nationally representative survey

Mariachiara Di Cesare, Zaid Bhatti, Sajid Bashir Soofi, Léa Fortunato et autres

BACKGROUND: Pakistan has one of the highest levels of child and maternal undernutrition worldwide, but little information about geographical and socioeconomic inequalities is available. We aimed to analyse anthropometric indicators for childhood and maternal nutrition at a district level in Pakistan and …

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Associations between Green Space and Health in English Cities: An Ecological, Cross-Sectional Study

Honor Bixby, Susan Hodgson, Léa Fortunato, Anna Hansell et autres

Green space has been identified as a modifiable feature of the urban environment and associations with physiological and psychological health have been reported at the local level. This study aims to assess whether these associations between health and green space are transferable …

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Associations between air pollution and socioeconomic characteristics, ethnicity and age profile of neighbourhoods in England and the Netherlands

Daniela Fecht, Paul D. Fischer, Léa Fortunato, Gerard Hoek et autres

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