Ralf Reinhard Tönjes

Correction: Analysis of PERV-C superinfection resistance using HA-tagged viruses

Merle Flecks, Nicole E. Fischer, Jacomina Krijnse Locker, Ralf Reinhard Tönjes et autres

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Aspects of Regulation of Xenotransplantation in Europe

Ralf Reinhard Tönjes

The Council of Europe (CoE) and the European Union (EU) share the same fundamental values, i.e., human rights, democracy and the rule of law, but are separate entities which perform different, yet complementary, roles. The CoE brings together governments from across Europe, …

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Combination of Anti-CD40 and Anti-CD40L Antibodies as Co-Stimulation Blockade in Preclinical Cardiac Xenotransplantation

Martin Bender, Jan‐Michael Abicht, Bruno Reichart, Elisabeth Neumann et autres

The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at preventing organ rejection. For example, the high …

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An Approach to Controlling Inflammation and Coagulation in Pig‐to‐Baboon Cardiac Xenotransplantation

Martin Bender, Bruno Reichart, Constança Figueiredo, Jonathan M. Burgmann et autres

INTRODUCTION: Inflammatory responses and coagulation disorders are a relevant challenge for successful cardiac xenotransplantation on its way to the clinic. To cope with this, an effective and clinically practicable anti-inflammatory and anti-coagulatory regimen is needed. The inflammatory and coagulatory response can be …

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The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights

Martin Bender, Jan‐Michael Abicht, Bruno Reichart, M. Patricia Leuschen et autres

Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive …

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Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023

Michael Schmoeckel, Matthias Längin, Bruno Reichart, Jan‐Michael Abicht et autres

This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and …

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301.2: Isolation and functional analysis of an ecotropic porcine endogenous retrovirus PERV-C from a Yucatan SLA D/D haplotype inbred miniature swine

Michael Rodrigues Costa, Nicole E. Fischer, Antonia Gronewold, Barbara Gulich et autres

Introduction: Yucatan SLAD/D (SLA, swine leukocyte antigen) haplotype inbred miniature swine are candidates as organ donors for xenotransplantation. Porcine endogenous retroviruses (PERV) inherit infectious potential if pig cells, tissues, or organs were transplanted to immunosuppressed human recipients. Particularly, ecotropic PERV-C that could …

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311.3: PCR and peptide based PCMV detection in pig - development and application of a combined testing procedure differentiating newly from latent infected pigs

Nicole E. Fischer, Barbara Gulich, Barbara Keßler, Matthias Längin et autres

Introduction: Porcine cytomegalovirus (PCMV) is widely distributed in pigs and difficult to detect due to latency. PCMV infection of source pigs was associated with early graft failure after cardiac and renal xenotransplantation into nonhuman primates. Importantly, PCMV infection of the first genetically …

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412.3: Analysis of PERV-C superinfection resistance using HA-tagged viruses

Merle Flecks, Ralf Reinhard Tönjes, Antonia W. Godehardt

Introduction: Being on the verge of clinical application xenotransplantation (XTx) using pigs as organ donors experienced a tremendous progress. However, XTx still bears a zoonotic risk of which the potential transmission of porcine endogenous retroviruses (PERV) needs to be surveyed. Despite the …

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Analysis of PERV-C superinfection resistance using HA-tagged viruses

Merle Flecks, Nicole E. Fischer, Jacomina Krijnse Locker, Ralf Reinhard Tönjes et autres

BACKGROUND: Using pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still a zoonotic risk associated with xenotransplantation, and the potential transmission of porcine endogenous retroviruses needs to be surveyed. …

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PCR and peptide based PCMV detection in pig – development and application of a combined testing procedure differentiating newly from latent infected pigs

Nicole E. Fischer, Barbara Gulich, Barbara Keßler, Matthias Längin et autres

Porcine cytomegalovirus (PCMV) is widely distributed in pigs and difficult to detect due to latency. PCMV infection of source pigs was associated with early graft failure after cardiac and renal xenotransplantation into nonhuman primates. Importantly, PCMV infection of the first genetically modified …

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Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLA D/D Inbred Miniature Swine

Michael Rodrigues Costa, Nicole E. Fischer, Antonia Gronewold, Barbara Gulich et autres

Yucatan SLA D/D haplotype miniature swine are candidates as organ donors for xenotransplantation. A full-length replication-competent PERV-C provirus was characterized. The provirus was chromosomally mapped in the pig genome. In vitro , the virus showed increased infectivity compared to other functional PERV-C …

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