Using De Novo Designed Protein Switches in C. elegans
Adam P. Berg, Joseph H. Kaefer, Connor M. Wakefield, Jakob L. Faber et autres
The ‘Latching Orthogonal Cage/Key pRoteins’ (LOCKR) system is a de novo designed protein Switch and Key. The Switch functions to cage a functional protein sequence, such as a degron, in the off or “locked” state. Upon Key addition, the Switch is turned …
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