Anne‐Marie Lompré

Inhibition of miR-223 Expression Using a Sponge Strategy Decreases Restenosis in Rat Injured Carotids

Eléonore M’Baya-Moutoula, Alexandre Marchand, Isabelle Six, Noura Bahrar et autres

OBJECTIVE: Restenosis is a frequent complication of angioplasty. It consists of a neointimal hyperplasia resulting from progression and migration of vascular smooth muscle cells (VSMC) into the vessel lumen. microRNA miR-223 has recently been shown to be involved in cardiovascular diseases including …

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Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling

Mathilde Keck, Mathilde Flamant, Nathalie Mougenot, Sophie Favier et autres

Abstract Early adaptive cardiac hypertrophy (EACH) is initially a compensatory process to optimize pump function. We reported the emergence of Orai3 activity during EACH. This study aimed to characterize how inflammation regulates store-independent activation of Orai3-calcium influx and to evaluate the functional …

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Effect of Intracoronary Administration of AAV1/SERCA2a on Ventricular Remodelling in Patients with Advanced Systolic Heart Failure: Results from the Agent-Hf Randomized Phase 2 Trial

Jean‐Sébastien Hulot, Joe‐Elie Salem, Alban Redheuil, Jean‐Philippe Collet et autres

Abstract Aims Restoration of sarco/endoplasmic reticulum Ca2+ATPase (SERCA2a) activity through gene transfer improved cardiac function in experimental and pilot studies in humans with heart failure. The AGENT-HF (NCT01966887) trial investigated the impact of adeno-associated virus (AAV1)/SERCA2a on ventricular remodelling using multimodality non-invasive …

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miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice

Alexandre Marchand, Fabrice Atassi, Nathalie Mougenot, Michel Clergue et autres

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Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice

Benoît Decouture, Elise Dréano, Tiphaine Belleville‐Rolland, Orjeta Kuci et autres

Molecules that reduce the level of cyclic adenosine 5'-monophosphate (cAMP) in the platelet cytosol, such as adenosine 5'-diphosphate (ADP) secreted from dense granules, trigger platelet activation. Therefore, any change in the distribution and/or availability of cyclic nucleotides or ADP may interfere with …

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TNFR2‐mediated Survival via Orai1‐3‐dependent Calcium Influx in Compensated Cardiac Hypertrophy

Catherine Pavoine, Mathilde Keck, Nathalie Mougenot, Alexandre Fuand et autres

Compensated cardiac hypertrophy (CH) is associated with the emergence of Orai1-3 voltage- and store-independent Ca2+ entry activated by Arachidonic Acid (AA). Our objectives were to determine Orai1-3 activating pathways and to evaluate the protective potential of Orai1-3 to limit transition to heart …

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Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

Caroline Claude, Nathalie Mougenot, Julia Bechaux, Lahouaria Hadri et autres

UNLABELLED: The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells. MRP4/ABCC4 deficient mice display a reduction in smooth muscle cells proliferation and a prevention of pulmonary hypertension in response to hypoxia. …

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Abstract 18751: Inhalable Delivery of AAV-based Mrp4/abcc4 Silencing Rna Attenuates Monocrotaline-induced Pulmonary Hypertension

Caroline Claude, Nathalie Mougenot, Julia Bechaux, Michel Clergue et autres

The ATP-binding cassette transporter MRP4 (encoded by ABCC4) functions as a plasma membrane efflux pump to extrude cyclic nucleotides from various cell types. MRP4 regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells (SMCs). In previous experiments, we have …

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Abstract 17620: Paracrine Actions of the Intracellular Second Messenger cAMP Secreted From Cardiac Myocytes

Yassine Sassi, Jeffery Truong, Andrea Ahles, Anne‐Marie Lompré et autres

Acute stimulation of cardiac β-adrenergic receptors and the resultant modulation of cyclic adenosine monophosphate (cAMP) signalling are crucial to increase cardiac function under stress. Yet, cont...

Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca 2+ -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells

Larissa Lipskaia, Régis Bobe, Jiqiu Chen, Irene C. Turnbull et autres

BACKGROUND: Phenotypic modulation or switching of vascular smooth muscle cells from a contractile/quiescent to a proliferative/synthetic phenotype plays a key role in vascular proliferative disorders such as atherosclerosis and restenosis. Although several calcium handling proteins that control differentiation of smooth muscle cells …

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Abstract 312: STIM1 And The Development Of Pressure-overload Induced Cardiac Hypertrophy In Rodents

Ludovic Bénard, Daniel S. Matasic, Mathilde Keck, Anne‐Marie Lompré et autres

STromal Interaction Molecule 1 (STIM1), a membrane protein of the sarcoplasmic reticulum, has recently been proposed as a positive regulator of cardiomyocyte growth by promoting Ca2+ entry through the plasma membrane and the activation of Ca2+-mediated signaling pathways. We studied the role …

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Abstract 198: Stim/orai Channel Complex In Normal And Hypertrophied Adult Cardiac Myocytes

Jean‐Sébastien Hulot, Youakim Saliba, Jérémy Fauconnier, Mathilde Keck et autres

Cardiac myocytes use Ca2+ not only in excitation-contraction coupling but also as a signaling molecule for cardiac growth. It is however unclear how Ca2+ triggers signaling in cardiac myocytes in the presence of the rapid and large Ca2+ fluctuations that occur during …

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