Frances M. Saccoccio

Beta-Lactam Dose Optimization Using Therapeutic Drug Monitoring in Pediatric Patients

Veena Venugopalan, Kalen B. Manasco, Ahmad Hachem, Hanzhi Gao et autres

OBJECTIVE: Beta-lactam therapeutic drug monitoring (BL-TDM) is underused in pediatric patients where drug exposure is highly variable. This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of BLs in pediatrics. PATIENTS AND METHODS: A retrospective observational cohort study of BL-TDM was conducted from …

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Ocular toxocariasis masquerading as toxoplasmosis: a case report and literature review

Jinghua Chen, Sarah Madison Duff, Frances M. Saccoccio, Nausheen Khuddus et autres

Background: False-negative and false-positive results in Toxoplasma serology are possible, and this could be misleading. Here, we report the case of a boy with Toxocara-associated panuveitis who was initially treated for toxoplasmosis owing to false-positive Toxoplasma immunoglobulin M (IgM) serology. Case Presentation: …

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Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

Matilda J. Moström, Shan Yu, Dollnovan Tran, Frances M. Saccoccio et autres

Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases worldwide occur after non-primary infection in CMV-seropositive …

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Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

Matilda J. Moström, Shan Yu, Dollnovan Tran, Frances M. Saccoccio et autres

Abstract Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases worldwide occur after non-primary infection in …

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Cat scratch disease: Pediatric case series for varying presentations of Bartonella henselae

Sallie Lin, Frances M. Saccoccio

Cat scratch disease (CSD) typically presents as regional lymphadenopathy, following inoculation via scratch, bite, or lick to an open wound by a young cat. Annual prevalence is 22,000 cases in the United States. Although CSD is self-limiting in the majority of cases, …

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Noninvasive Prediction of Congenital Cytomegalovirus Infection After Maternal Primary Infection

Dwight J. Rouse, Lida M. Fette, Brenna L. Hughes, George R. Saade et autres

OBJECTIVE: To develop and internally validate a noninvasive method for the prediction of congenital cytomegalovirus (CMV) infection after primary maternal CMV infection. METHODS: We conducted a secondary analysis of a multicenter randomized placebo-controlled trial of CMV hyperimmune globulin to prevent congenital infection. …

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Risk Factors for CMV Viremia and Treatment-Associated Adverse Events Among Pediatric Hematopoietic Stem Cell Transplant Recipients

Sarah M. Heston, John Tanaka, Kirsten Jenkins, Richard Vinesett et autres

BACKGROUND: Cytomegalovirus (CMV) causes substantial morbidity and mortality after hematopoietic stem cell transplantation (HSCT). There are limited data on risk factors for CMV viremia and the safety of antiviral medications used to treat CMV in children. METHODS: We conducted a single-center retrospective …

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#54: Sensitivity and Specificity of Procalcitonin vs C Reactive Protein in Identifying Pediatric Bacterial infections

Sara Kim, Avni Bhatt, Silvana Carr, Frances M. Saccoccio et autres

Abstract Background Procalcitonin (PCT) and c-reactive protein (CRP) have been utilized in children to assess risk for serious bacterial infections. However, there have been different cut-offs reported for PCT and CRP, which yield different sensitivity and specificity. This study aims to compare …

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Ocular Toxocariasis Masquerading as Toxoplasmosis

Sarah Madison Duff, Frances M. Saccoccio, Nausheen Khuddus, Gibran S. Khurshid et autres

Abstract PurposeTo report panuveitis due to Toxocara, with positive Toxoplasma serology. ObservationA nine-year-old boy presented with a panuveitis, intermittent headaches, and a visual acuity of 20/400 in his left eye. Slit lamp examination showed anterior chamber cells and flare without keratic precipitates …

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Risk Factors for CMV Viremia Among Pediatric Hematopoietic Stem Cell Transplantation Recipients at a Single Institution

Sarah M. Heston, Rebecca Young, John Tanaka, Kirsten Jenkins et autres

A case report of primary amebic meningoencephalitis in North Florida

Saad Anjum, Karna Mangrola, Garrett Fitzpatrick, Kimberly Stockdale et autres

Primary amebic meningoencephalitis is a rare, usually fatal disease, caused by Naegleria fowleri. This case highlights the challenging clinicopathologic diagnosis in a 13-year-old boy who swam in freshwater in northern Florida where a previous case had exposure to a body of water …

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An uncommon cause of soft tissue and knee infection after penetrating injury in a non-immunocompromised adolescent male

Travis Bryant, Savannah Ellenwood, Olivia Butters, Frances M. Saccoccio

Non-cholerae Vibrio species and Shewanella species are organisms that rarely infect humans. Symptoms can range from gastroenteritis to wound infections to septicemia. In addition, these infections can lead to multiple poor outcomes ranging from amputations to death. We present a case of …

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