Gregory S. Ladics

Dietary administration of α-terpineol to Sprague-Dawley rats for 90 days

M Aubanel, Christopher Y. Choi, Jan C. R. Demyttenaere, Maodo Malick Diop et autres

α-Terpineol is a flavoring ingredient that occurs naturally in spices and foods. It has been evaluated by regulatory and scientific expert bodies such as the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1999 and the European Food Safety Authority (EFSA) …

ie, us, be, fr, ch, sg, jp, de (code pays fourni par la source)

Safety evaluation of a fungal beta-glucanase

Dnyaneshwar Jondhale, Gregory S. Ladics

Pig and poultry feed are often included with beta-glucanase to alleviate the anti-nutritional impacts of beta-glucans found in many cereal grains. Safety studies were conducted on beta-glucanase, including skin and eye irritation, dermal sensitization, a 90-day rat oral subchronic study, and genotoxicity, …

in, us, fr (code pays fourni par la source)

Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay

Isabelle Lee, Andy Forreryd, Mihwa Na, Isabella Schember et autres

Potency and quantitative risk assessment are essential for determining safe concentrations for the for­mulation of potential skin sensitizers into consumer products. Several new approach methodologies (NAMs) for skin sensitization hazard assessment have been adopted in OECD test guidelines. Work is ongoing to …

us (code pays fourni par la source)

Editorial: What have we learned over the last 25 years assessing novel food and protein allergenicity

Scott McClain, Gregory S. Ladics

Where allergy science has moved in 25 years overlaps with the maturation of risk assessment and its origins in toxicology, more generally. In delivering regulatory science evaluations of food safety, it's been noted that "allergy assessments" really don't satisfy the needs of …

us (code pays fourni par la source)

Determination of OTNE-induced thyroid effects within an adverse outcome pathway (AOP) network

Etje Hulzebos, Todd J Stedeford, Paul Sterchele, Gregory S. Ladics

Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) is a synthetic fragrance ingredient. OTNE was evaluated in repeated-dose toxicological studies. Target organs via oral and dermal routes were the liver and skin/liver, respectively. Effects were observed on the thyroid and thyroid hormones, suggesting hypothalamic-pituitary-thyroid axis perturbation. We investigated …

fr, us (code pays fourni par la source)

Protein Allergy and Genetically Engineered Crops

Gregory S. Ladics, Andre Silvanovich

us (code pays fourni par la source)

GARDskin dose-response assay and its application in conducting Quantitative Risk Assessment (QRA) for fragrance materials using a Next Generation Risk Assessment (NGRA) framework

Shashikiran Donthamsetty, Andy Forreryd, Paul Sterchele, Xiao yuan Huang et autres

Development of New Approach Methodologies (NAMs) capable of providing a No Expected Sensitization Induction Level (NESIL) value remains a high priority for the fragrance industry for conducting a Quantitative Risk Assesment (QRA) to evaluate dermal sensitization. The in vitro GARDskin assay was …

us, fr (code pays fourni par la source)

Cashmeran as a potential endocrine disrupting chemical: What does the weight-of-the-evidence indicate?

Sakshi Tayal, Marten A. Schults, Paul Sterchele, Etje Hulzebos et autres

Cashmeran is a fragrance ingredient. Risk assessments are available but have not focused on its endocrine disruptor potential. The objective was to evaluate Cashmeran as a potential endocrine-disrupting chemical (EDC). The assessment was based on data from US EPA's CompTox Chemicals Dashboard, …

us (code pays fourni par la source)

P22-43: The GARDskin Dose-Response assay for determination of a point-of-departure (PoD) for Next Generation Risk Assessment (NGRA) of skin sensitizers: A case study using isocyclocitral

P. Nählstedt, S. Donthamsetty, Paul Sterchele, Xuhua Huang et autres

us (code pays fourni par la source)

Impact of Food Matrices on Digestibility of Allergens and Poorly Allergenic Homologs

Jaap H. Akkerdaas, Antonella Cianferoni, Emir Islamovic, John L. Kough et autres

Background: Protease resistance is considered a risk factor for allergenicity of proteins, although the correlation is low. It is nonetheless a part of the weight-of-evidence approach, proposed by Codex, for assessing the allergenicity risk of novel food proteins. Susceptibility of proteins to …

nl, us, dk (code pays fourni par la source)

The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement

Ronald van Ree, Dexter Sapiter Ballerda, M. Cecilia Berin, Laurent Beuf et autres

Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public safety in general. Over recent years, screening for potential new allergens …

nl, us, fr, at, dk (code pays fourni par la source)

A Weight-of-the-Evidence Approach for Evaluating, in Lieu of Animal Studies, the Potential of a Novel Polysaccharide Polymer to Produce Lung Overload

Gregory S. Ladics, Owen T. Price, Shantanu Kelkar, Scott Herkimer et autres

studies described here for the novel polysaccharide provide a useful weight of evidence approach in the absence of animal studies for the evaluation of polymer substances where polymer lung overload may be a concern.

us (code pays fourni par la source)