Xin Ling

Construction and multi-omics validation of a five-gene ferroptosis-based model for predicting prognosis and therapy response in pancreatic ductal adenocarcinoma with immune landscape analysis

Liu W, Yifen Shen, Li Rao, Zhenguo Qiao et autres

BACKGROUND: Ferroptosis is an iron-dependent programmed cell death, which plays a complex role in pancreatic ductal adenocarcinoma (PDAC), regulating both tumor development and immune interaction. However, the clinical significance and potential molecular mechanism of ferroptosis in PDAC have not been fully clarified, …

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Risk factors and anticoagulation therapy for splanchnic vein thrombosis and sinistral portal hypertension in acute pancreatitis: A two-center study

Xin Ling, Yuan-Yuan Ai, Ze-Wen Zhang, Lihui Lin et autres

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Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis

Xin Ling, Chaoqun Han, Liping Sheng, Zhen Ding

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Impaired Autophagic Flux in Adipose Tissue Aggravates Pancreatic Injury in Obesity‐Related Severe Acute Pancreatitis

Li‐Ping Sheng, Guo‐Chen Shang, Chaoqun Han, Xin Ling et autres

BACKGROUND: Adipose tissue (AT) playing a crucial role in obesity-related pancreatitis. This study investigated the impact of autophagy in AT on pancreatic injury during obesity-related severe acute pancreatitis (SAP). METHODS: Non-obese and obese mice were induced using a normal diet (ND) or …

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Application of Suspension Training Combined with Vagus Nerve Stimulation for Pain Management in Spinal Rehabilitation

Xin Ling

In order to evaluate the clinical value of suspension training combined with non-invasive vagus nerve stimulation in spinal rehabilitation pain management, 60 patients with chronic spinal pain were intervened for 8 weeks, and two control groups, namely the single suspension training group …

Remimazolam-Remifentanil versus Propofol-Remifentanil for Spontaneous Ventilation During Fiberoptic Bronchoscopy: A Randomized Controlled Trial

Jinghao Huang, H. Gao, Lin Li, Xin Ling et autres

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Acute Pain Management with Ultrasound-Guided Erector Spinae Plane Block and Serratus Anterior Plane Block in Patients Undergoing Coronary Artery Bypass via Mini-thoracotomy: A Randomized Controlled Trial

Xin Ling, Lu Wang, Yi Feng

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Efficacy of ultrasound-guided erector spinae plane block on analgesia and quality of recovery after minimally invasive direct coronary artery bypass surgery: protocol for a randomized controlled trial

Xin Ling, Lu Wang, Yi Feng

BACKGROUND: Minimally invasive direct coronary artery bypass (MIDCAB) surgery offers an effective option for coronary artery disease (CAD) patients with the avoidance of median sternotomy and fast postoperative recovery. However, MIDCAB is still associated with significant postoperative pain which may lead to …

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Ultrasound-guided erector spinae plane block for postoperative analgesia in patients undergoing minimally invasive direct coronary artery bypass surgery: a double-blinded randomized controlled trial

Xin Ling, Lu Wang, Yi Feng

PURPOSE: Minimally invasive direct coronary artery bypass (MIDCAB) surgery is associated with significant postoperative pain. We aimed to investigate the efficacy of ultrasound-guided erector spinae plane block (ESPB) for analgesia after MIDCAB. METHODS: We conducted randomized controlled trial in 60 patients undergoing …

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Diagnostic role of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in abdominal lymphadenopathy of unknown etiology

Wenli Wang, Chaoqun Han, Xin Ling, Xianwen Guo et autres

Background: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an established method for the evaluation of abdominal organ lesions. However, there are few studies on EUS-FNA for abdominal lymph node (LN) lesions. The purpose of this study was to evaluate the diagnostic role …

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Application of artificial intelligence to digital‐rapid on‐site cytopathology evaluation during endoscopic ultrasound‐guided fine needle aspiration: A proof‐of‐concept study

Rong Lin, Li‐Ping Sheng, Chaoqun Han, Xianwen Guo et autres

BACKGROUND: During endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), cytopathology with rapid on-site evaluation (ROSE) can improve diagnostic yield and accuracy. However, ROSE is unavailable in most Asian and European institutions because of the shortage of cytopathologists. Therefore, developing computer-assisted diagnostic tools to …

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Proanthocyanidins suppress NLRP3 inflammasome and M1 macrophage polarization to alleviate severe acute pancreatitis in mice

Li‐Ping Sheng, Chaoqun Han, Xin Ling, Xianwen Guo et autres

The role of reactive oxygen species (ROS) is crucial for the pathogenesis of acute pancreatitis (AP). Proanthocyanidins (PAs) have been confirmed to exert antioxidant activity. Our study aimed to determine whether PAs alleviated SAP via reducing ROS, suppressing NLRP3 inflammasome, and inhibiting …

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