Megan Gooey

Evaluation and comparison of three high throughput assays (Alinity m CMV, Aptima CMV Quant and cobas CMV) for quantifying CMV DNA in plasma samples

Jodie D'Costa, Doris Chibo, Katherine Soloczynskyj, Mitchell Batty et autres

au (code pays fourni par la source)

Surveillance testing using salivary RT-PCR for SARS-CoV-2 in managed quarantine facilities in Australia: A laboratory validation and implementation study

Adam Jenney, Doris Chibo, Mitchell Batty, Julian Druce et autres

Background: Regular repeat surveillance testing is a strategy to identify asymptomatic individuals with SARS-CoV-2 infections in high-risk work settings to prevent onward community transmission. Saliva sampling is less invasive compared to nasal/oropharyngeal sampling, thus making it suitable for regular testing. In this …

au (code pays fourni par la source)

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Jennifer M. Zerbato, Georges Khoury, Wei Zhao, Matthew J. Gartner et autres

BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretroviral therapy (ART) is to activate latent HIV infection with a latency reversing agent (LRA). Surrogate markers that accurately measure virus production following …

au, us (code pays fourni par la source)

Analysis of transmitted HIV drug resistance from 2005 to 2015 in Victoria, Australia: a comparison of the old and the new

J D'Costa, Megan Gooey, Nicole Richards, Rizmina Sameer et autres

Background Baseline genotyping is part of standard-of-care treatment. It reveals that transmitted drug resistance (TDR) continues to be important for the management of HIV infection. Attention is typically focused on determining whether resistance to the protease inhibitors (PI) and reverse transcriptase inhibitors …

au, ca (code pays fourni par la source)

Integrase-resistant HIV in an antiretroviral-naive patient in Australia

Nastaran Rafiei, Ian Woolley, Tony M. Korman, Doris Chibo et autres

Integrase strand transfer inhibitors (INSTIs) have become an important part of antiretroviral therapy (ART) since the introduction of raltegravir in 2007 [1,2]. International guidelines recommend INSTIs, raltegravir, dolutegravir, or elvitegravir, as part of the regimens for treatment initiation in ART-naive individuals because …

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Understanding the HIV co-receptor tropism assay

Doris Chibo, Jodie A Nicholls, Megan Gooey, Nicole Richards et autres

au (code pays fourni par la source)

Prevalence of transmitted HIV drug resistance since the availability of highly active antiretroviral therapy

Jessica S. Russell, Doris Chibo, Matthew B Kaye, Megan Gooey et autres

We investigated the prevalence of HIV-1-associated transmitted drug resistance (TDR) in Victoria from the time of first availability of highly active antiretroviral therapy. Drug resistance genotyping was performed on virus present in blood samples collected from individuals with serologically confirmed primary infection, …

au (code pays fourni par la source)

Prevalence of transmitted HIV drug resistance since the availability of highly active antiretroviral therapy

Jessica S. Russell, Doris Chibo, Matthew B Kaye, Megan Gooey et autres

We investigated the prevalence of HIV-1-associated transmitted drug resistance (TDR) in Victoria from the time of first availability of highly active antiretroviral therapy. Drug resistance genotyping was performed on virus present in blood samples collected from individuals with serologically confirmed primary infection, …

au (code pays fourni par la source)

Virological fitness of HIV in patients with resistance to enfuvirtide

Doris Chibo, Norman Roth, Vanessa Roulet, Katharina Skrabal et autres

Resistance to the HIV fusion inhibitor enfuvirtide is associated with mutations in the first heptad repeat region of gp41, but little is known of their impact on replicative fitness in vivo. We followed seven patients undergoing salvage therapy that included enfuvirtide in …

au, us, fr (code pays fourni par la source)