Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy
Alberto G. Conti, Alexander C. Evans, Teresa von Linde, Christian Deo T. Deguit et autres
Adoptive T cell therapies are limited by poor persistence of transferred cells. Attempts to enhance persistence have focused on genetic induction of constitutively hyperactivated but potentially oncogenic T cell states. Physiological T cell responses are maintained by quiescent stem-like/memory cells dependent upon …
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