Fatemeh Keshavarz

Pre-treatment of cabozantinib prior to hypofractionated radiotherapy increases immunomodulatory effects and tumor size reduction in a 4T1 breast cancer murine model

Fatemeh Keshavarz, Ameneh Kouchaki, Mohsen Soltanshahi, Mahmoud Reza Jaafari et autres

Radiotherapy is one of the treatments used in breast cancer, which, in addition to immunomodulatory effects, causes immunosuppressive effects such as the increase in myeloid-derived suppressor cells (MDSCs). Cabozantinib is a multikinase inhibitor that targets multiple tyrosine kinases and has been shown …

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Accelerating materials discovery for water crisis: Multi-objective machine learning for atmospheric water harvesting by MOFs

Fatemeh Keshavarz, Charalampos G. Livas, Emmanuel Tylianakis, B. Barbiellini et autres

Abstract Addressing the global water crisis requires efficient water supply solutions. Metal-organic frameworks (MOFs) offer promise for atmospheric water harvesting (AWH). However, many MOFs suffer from poor water stability or limited adsorption capacity. To accelerate discovery, we conceptualize structure–property relationships and develop …

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Metal–Organic Framework Flexibility Boosting Atmospheric Water Harvesting by a Zinc-Based Glycine–Glyoxime–Histidine Framework

Fatemeh Keshavarz, Stefanie A. Kroll, Jakob Gamper, Josef M. Gallmetzer et autres

Structural flexibility of metal–organic frameworks (MOFs) is both a challenge and an opportunity, depending on the MOF’s properties and the proposed applications. Here, we focus on ZnGGH, a peptide-based flexible MOF that switches from its “gate-closed” ZnGGH-9 conformer to “gate-open” ZnGGH-4 upon …

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Multi-tyrosine kinase inhibitors: exploring immunomodulatory effects on various immune cell types in cancer

Fatemeh Keshavarz, Mohsen Soltanshahi, Malaksima Ayadilord, Faezeh Sadat Mortazavi et autres

TKIs, or tyrosine kinase inhibitors, are pharmaceutical agents used in cancer treatment because they can block or inhibit enzymes called tyrosine kinases. These enzymes are essential in regulating cell processes such as growth, differentiation, metabolism, and survival. Multi-TKIs target several tyrosine kinases …

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Dual impact of water on stability of metal–organic frameworks

Fatemeh Keshavarz

The widespread application of metal-organic frameworks (MOFs) is hindered by their hydrolytic instability in aqueous and humid environments. To overcome this bottleneck, herein, we evaluate four representative MOFs-MOF-303 (highly stable), MIL-127(Fe) (stable), HKUST-1 (moderately unstable), and UMCM-1 (unstable) - using periodic and …

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Evaluation of Factors Associated with Post-Tonsillectomy Bleeding in Adults.

Masoud Janipour, Fatemeh Keshavarz, Amirhossein Babaei

Introduction: Post-tonsillectomy hemorrhage is one of the most common and potentially life-threatening complications of tonsillectomy in adults and may result in readmission or reoperation. Adults are known to have a higher bleeding risk compared with children due to increased inflammation, comorbid factors, …

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Association between the digestion-resistant bioactive peptide content in dairy products and the risk of sarcopenia in Iranian elderly: a case-control study

Fatemeh Keshavarz, Seyyed Mohammad Alavi, Sazin Yarmand, Amirhossein Nazarian et autres

BACKGROUND: Sarcopenia is a generalized and progressive loss of skeletal muscle mass and function, which is associated with various adverse health outcomes, such as fractures, impaired mobility, and increased mortality. Bioactive peptides (BPs) are absorbable protein fragments that remain bioaccessible after digestion. …

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Nanoliposome loaded with 5-fluorouracil and Dorema aucheri extract reduces tumor growth in a mouse model of colorectal cancer

Fatemeh Keshavarz, Firouzeh Nasimi, Hassan Bardania, Mohsen Soltanshahi et autres

The rising incidence of colorectal cancer (CRC) and the limited success of conventional therapies have spurred efforts to identify promising new drugs with fewer side effects. Dorema aucheri (DA) has shown potential as An Anti-cancer agent. Additionally, 5-fluorouracil (5-FU), a chemotherapy drug …

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Self-care behaviors towards coronavirus disease 2019 (COVID-19) prevention in hemodialysis patients: A cross-sectional study

Nasrin Rasoulzadeh, Fatemeh Keshavarz, Fatemeh Mohammad Hosseinzadeh, Ra'na Haddadi

Since individuals with underlying health conditions are at a higher risk of contracting coronavirus disease 2019 (COVID-19), hemodialysis patients are among the most susceptible and vulnerable groups to this disease. Self-care behaviors are recognized as the most fundamental approach to preventing diseases, …

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Process Simulation and Comparative Performance Evaluation of SIFSIX-3- Cu and Mg-MOF-74 for Direct Air CO₂ Capture in Packed Bed Columns

Behrouz Bayati, Nima Rezaei, Fatemeh Keshavarz, Sohrab Zendehboudi et autres

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The association between global diet quality index with novel cardiovascular risk factors and problem areas in diabetes scale (PAID) among patients with type 2 diabetes mellitus

Fatemeh Keshavarz, Ensieh Nasli‐Esfahani, Mobina Zeinalabedini, Leila Azadbakht

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Pharmacological preventions and treatments for pericardial complications after open heart surgeries

Alireza Malektojari, Rosa Tahmasebipour, Maedeh Fadaeihosein, Sara Ghazizadeh et autres

BACKGROUND: Pericardial complications following cardiac surgery are common and debilitating, significantly impacting patients' survival. We performed this network meta-analysis to identify the most effective and safest preventions and treatments for pericardial complications following cardiac surgery. METHODS: We systematically searched PubMed/MEDLINE, EMBASE and …

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