Accès ouvert
2026
preprint
OpenAlex
Anouk van der Net, Klara Beslmüller, Nicole van Vliet, Margherita Tavasso et autres
Summary Septins are cytoskeletal proteins that contribute to essential cellular processes such as cell migration and cell division through interactions with the cell membrane and the cytoskeleton. High expression of septins is correlated with breast cancer malignancy and promotes cell invasion, but …
nl
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Accès ouvert
2025
article
OpenAlex
Laurens W. J. Bosman, Hamid el Azzouzi, Lieke Kros, Yanto Ridwan et autres
Abstract Williams syndrome is a developmental disorder caused by a microdeletion entailing the loss of a single copy of 25–27 genes on chromosome 7q11.23. Patients suffer from cardiovascular and neuropsychological symptoms. Structural abnormalities of the cardiovascular system in Williams syndrome have been …
nl, cn
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Accès ouvert
2025
article
OpenAlex
James P. Conboy, Mathilde G Lettinga, Nicole van Vliet, Lilli Winter et autres
cells, suggesting a more sparse cytoskeletal network. Confocal imaging indicated that this was due to a marked change in the architecture of the vimentin network, from a fine meshwork in wild-type cells to a bundled network in the plectin knockout cells. Our …
nl, at, us
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Accès ouvert
2025
preprint
OpenAlex
James P. Conboy, Mathilde G Lettinga, Nicole van Vliet, Lilli Winter et autres
ABSTRACT Plectin is a giant protein of the plakin family that crosslinks the cytoskeleton of mammalian cells. It is expressed in virtually all tissues and its dysfunction is associated with various diseases such as skin blistering. There is evidence that plectin regulates …
nl, at, us
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Accès ouvert
2025
article
OpenAlex
Sanne J. M. Stefens, Janette van der Linden, José María Heredia‐Genestar, Renata M. C. Brandt et autres
ABSTRACT Aging is a major risk factor for cardiovascular diseases, and the accumulation of DNA damage significantly contributes to the aging process. This study aimed to identify the underlying molecular mechanisms of vascular aging in DNA‐repair‐deficient progeroid Ercc1 Δ/− mice and to …
nl, de
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Accès ouvert
2025
article
OpenAlex
Elza D. van Deel, Matthijs Snelders, Nicole van Vliet, Luuk te Riet et autres
Abstract The prevailing view of fibulin-4 deficient mice is that the cardiac phenotype is the result of aortic and/or valvular disease. In the present study, we have tested whether the cardiac phenotype is, at least in part, the consequence of primary cardiac …
nl, gb, us, jp, ca
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Accès ouvert
2024
article
OpenAlex
Sanne J. M. Stefens, Nicole van Vliet, Arne IJpma, Joyce Burger et autres
Abstract Aortic aneurysms are dilatations of the aorta that can rupture when left untreated. We used the aneurysmal Fibulin-4R/R mouse model to further unravel the underlying mechanisms of aneurysm formation. RNA sequencing of 3-month-old Fibulin-4R/R aortas revealed significant upregulation of senescence-associated secretory …
nl
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Accès ouvert
2024
article
OpenAlex
Bibi S. van Thiel, Martine de Boer, Yanto Ridwan, Marion G. J. de Kleijnen et autres
PURPOSE: In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT and fluorescence molecular tomography (FMT) imaging techniques in Ercc1 mutant mice. Ercc1 is involved in multiple DNA repair pathways, and its mutations …
nl, de
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Accès ouvert
2024
article
OpenAlex
Janette van der Linden, Sanne J. M. Stefens, José María Heredia‐Genestar, Yanto Ridwan et autres
Abstract Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the …
nl, us
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Accès ouvert
2023
preprint
OpenAlex
Laurens W. J. Bosman, Lieke Kros, Nicole van Vliet, Yanto Ridwan et autres
Abstract Williams syndrome is a developmental disorder caused by a microdeletion entailing the loss of a single copy of 25-27 genes on chromosome 7q11.23. Patients suffer from cardiovascular and neuropsychological symptoms. Structural abnormalities of the cardiovascular system in Williams syndrome have been …
nl, cn, gb
(code pays fourni par la source)
Accès ouvert
2022
erratum
OpenAlex
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn et autres
[This corrects the article DOI: 10.3389/fragi.2022.1005322.].
nl, de, it
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2022
conference-abstract
OpenAlex
Elza van Deel, Nicole van Vliet, Thierry van den Bosch, Ariane van Spreeuwel et autres
Cutis laxa is a rare disorder caused by mutations in the extracellular matrix (ECM) protein Fibulin-4 and patients are susceptible to stress-induced cardiac dysfunction. Mice with a 75% reduction in Fibulin-4 expression (Fibulin-4 R/R ) developed cardiac hypertrophy, dilation and dysfunction as …
nl, jp
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