Young Hoon Ryu

Distinct Spatiotemporal Patterns of Dopaminergic and Metabolic Imaging in De Novo Parkinson's Disease

Jung Hyun Lee, Han Kyu Na, Sung Jun Ahn, Mina Park et autres

BACKGROUND: Understanding the heterogeneity of Parkinson's disease (PD) is essential to guide patient care, prognosis, and treatment. OBJECTIVE: F-FP-CIT) PET, and Subtype and Stage Inference (SuStaIn) algorithm to define subtypes in drug-naive patients with PD. METHODS: F-FP-CIT, and brain magnetic resonance imaging …

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Functional Reorganization of Corticostriatal Connectivity Across the Degree of Nigrostriatal Degeneration in Parkinson Disease

Han Soo Yoo, Han‐Kyeol Kim, Mina Park, Sung Jun Ahn et autres

BACKGROUND AND OBJECTIVES: In Parkinson disease (PD), deafferentation of nigral dopaminergic neurons to the striatum leads to striatal dopamine depletion and impaired direct and indirect basal ganglia pathways, which in turn reduce thalamocortical excitation and ultimately lead to parkinsonism. Therefore, understanding the …

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Interplay of age-sensitive cortical vulnerability and dopaminergic degeneration in clinical manifestations of Parkinson’s disease

Sungwoo Kang, Han Kyu Na, So Hoon Yoon, Han-Kyeol Kim et autres

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Plasma p‐tau217 predicts PET‐based pathological staging for precision Alzheimer disease assessment

Han‐Kyeol Kim, Jae Hoon Lee, Joong‐Hyun Chun, You Jin Kim et autres

INTRODUCTION: While positron emission tomography (PET) is the standard for pathological staging, its limited availability necessitates accessible alternatives. We evaluated plasma biomarkers for detecting PET-based stages using single-axis (Thal/Braak) and integrated A/T composite models. METHODS: We enrolled 237 AD spectrum participants undergoing …

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APOE genotype-dependent association between plasma p-tau217 and amyloid pathology in Alzheimer’s disease

Han-Kyeol Kim, Jae Hoon Lee, Joong‐Hyun Chun, Mina Park et autres

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Association of dopamine depletion and cholinergic basal forebrain atrophy with brain metabolism and cognition in Parkinson's disease

Jung Hyun Lee, Mina Park, Sung Jun Ahn, Jae‐Hoon Lee et autres

Background Cognitive dysfunction is one of the most debilitating non-motor symptoms of Parkinson's disease (PD). This study aimed to explore the interplay between altered neurotransmitter activities, including dopamine and acetylcholine, and brain metabolism in cognitive decline in PD. Methods We enrolled 172 …

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Development and validation of a LASSO-Based FDG PET/CT model for predicting colorectal adenoma in asymptomatic individuals undergoing colonoscopy

Jeonghyun Kang, Youngmin Kim, Hye Sun Lee, Young Hoon Ryu et autres

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Quantitative assessment of condylar bone changes in osteoarthritis patients using single-photon emission computed tomography/computed tomography and magnetic resonance imaging

Jae‐Hoon Lee, Kug Jin Jeon, Jong‐Ki Huh, Hye-Sun Kim et autres

OBJECTIVES: This retrospective study aimed to investigate and evaluate the signal intensity ratio (SIR) on magnetic resonance imaging (MRI) and maximum standard uptake value (SUVmax) and Hounsfield unit (HU) values on single-photon emission computed tomography/computed tomography (SPECT/CT) in relation to the diagnosis …

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Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition

Han Kyu Na, Hanna Cho, Hye Sun Lee, Han‐Kyeol Kim et autres

INTRODUCTION: With accumulating evidence that motor manifestations in Alzheimer's disease (AD) may emerge from AD pathology independent of other copathologies, we investigated the neural basis of motor dysfunction under the amyloid/tau/neurodegeneration (ATN) framework. METHODS: This study included 125 patients with AD, excluding …

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Enhancing metabolic syndrome prediction using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography data and machine learning: a comprehensive analysis

Jeonghyun Kang, Jae‐Hoon Lee, Hye Sun Lee, Tae Joo Jeon et autres

Background: Metabolic syndrome (MetS) is a complex health concern and the incidence of MetS is rising, even among the general population, necessitating effective identification and management strategies. This study aimed to determine if a predictive model using variables from fluorine-18 fluorodeoxyglucose positron …

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Comparison of the maximum standardized uptake value and magnetic resonance imaging characteristics between temporomandibular joint osteoarthrosis and osteoarthritis

Jaeyoung Kim, Chaeyeon Lee, Jae Hoon Lee, Young Hoon Ryu et autres

Osteoarthritis (OAI) and osteoarthrosis (OAO) are subsets of degenerative joint diseases affecting the temporomandibular joint (TMJ), distinguished by the presence of joint pain. However, clinical diagnosis based on pain alone is challenging. This study aimed to differentiate OAI from OAO using imaging …

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Voluntary Swimming Reduces Amyloid Pathology in an Alzheimer’s Mouse Brain: An Integrated Amyloid PET/CT and Light-Sheet Microscopy Evaluation

Hye Joo Son, Suk Hyun Lee, Jang Woo Park, Chan-Woo Park et autres

PURPOSE: Despite numerous observational studies linking exercise to reduced dementia risk, RCT level evidences remain limited to validate physical activity as an effective resistance-augmenting lifestyle intervention. However, transgenic Alzheimer's disease (AD) mouse models circumvent the confounding factors and adherence challenges of human …

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