Yanqing Song

Programmable 3D Microfluidics Reveals Motility‐Driven Antibiotic Resistance Evolution in Gradients

Xiaobo Li, Jianan Yin, Yanqing Song, Andrew Glidle et autres

Antibiotic resistance has become a serious threat to global health. It frequently emerges in real-world environments such as biofilms, where antibiotic gradients impose selective pressures that drive bacterial adaptation. However, the mechanisms underlying resistance development remain poorly understood, largely due to challenges …

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Comparative clinical response, safety, and institutional drug use efficiency of intravenous azithromycin versus erythromycin in pediatric Mycoplasma pneumoniae pneumonia: a real-world evidence study

Jiayu Deng, Yifei Li, Changxin Liu, Xiaoyu Qu et autres

Objective This study aims to compare real-world clinical response, safety, and institutional medication efficiency of intravenous (IV) azithromycin (AZI) versus erythromycin lactobionate (ERY) in hospitalized children with Mycoplasma pneumoniae pneumonia (MPP). Methods A retrospective cohort of 1,049 children with PCR- or serology-confirmed …

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Drug‐Induced Liver Injury Associated With Moxifloxacin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System and a Real‐World Retrospective Study

Yanqing Song, Chunzi Li, Xiaoyue Liu, Huan Gao

OBJECTIVE: While current studies have focused on the incidence of moxifloxacin-associated liver injury, risk factors and clinical characteristics for moxifloxacin-induced liver injury in hospitalized patients remain unexplored. METHODS: We analysed antibiotic-induced liver injury using the US Food and Drug Administration Adverse Event …

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Post-marketing safety evaluation of Guhong Injection: a multicenter, prospective real-world study of 30,000 cases in China

Jiayu Deng, Xiangfeng Wang, Changxin Liu, Yanqing Song

OBJECTIVE: To evaluate the incidence, nature, and clinical manifestations of adverse events (AEs) and adverse drug reactions (ADRs) associated with Guhong Injection, and to provide evidence for the safe clinical use of this drug. METHODS: A prospective, multicenter, large-scale, registry-based hospital centralized …

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Real-world efficacy and safety of cefepime for pediatric community-acquired pneumonia: a propensity score-matched study

Changxin Liu, Yanqing Song

Objective: This study aimed to evaluate the real-world clinical efficacy and safety of cefepime in treating pediatric community-acquired pneumonia (CAP), comparing it with other broad-spectrum antibiotics, including cefoperazone-sulbactam and meropenem, using a propensity score-matched design. Methods: A retrospective, propensity score-matched cohort study …

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A simple three-dimensional microfluidic platform for studying chemotaxis and cell sorting

Xiaobo Li, Yanqing Song, Andrew Glidle, Cindy J. Smith et autres

strain was discovered with substantial cellulose degradation capabilities. These results illustrate the strong potential of this microfluidic platform for investigating broad processes involving bacterial chemotaxis and for discovering functional microbes.

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Emerging single-cell microfluidic technology for microbiology

Yanqing Song, Jianan Yin, Wei E. Huang, Bei Li et autres

Cell-to-cell differences exist ubiquitously in microbial communities. This individual heterogeneity, often manifested in cell phenotypic function (e.g., antibiotic resistance), can be critical in determining the fate of a microbial community. However, studying such heterogeneity in microbial communities remains a significant challenge due …

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Remarkable adsorption of As(V) by Fe3+ and Mg2+ modified alginate porous beads (Fe/Mg-SA) via a facile method

Donghui Chen, Yanqing Song, Hong Li, Mengyu Ma et autres

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Potential role of irisin in digestive system diseases

Yueming Zhang, Linxian Zhao, Huan Gao, Jinghui Zhai et autres

Digestive system diseases (DSD) are very complex conditions that severely threaten human health. Therefore, there is an urgent need to develop new pharmacological treatment strategies. Irisin, a myokine discovered in 2012, is produced by fibronectin type III domain-containing protein 5 (FNDC5), which …

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Single-cell microfluidics enabled dynamic evaluation of drug combinations on antibiotic resistance bacteria

Xiaobo Li, Yanqing Song, Xiuzhao Chen, Jianan Yin et autres

The rapid spread of antibiotic resistance has become a significant threat to global health, yet the development of new antibiotics is outpaced by emerging new resistance. To treat multidrug-resistant bacteria and prolong the lifetime of existing antibiotics, a productive strategy is to …

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Study on the Spatial and Temporal Distribution Characteristics of Large-Scale Wind-PV Base by Using Two-Layer Clustering Approach

Wenzhe Huang, Cenglin Ruan, Cheng Chen, Yanqing Song et autres

As the installed capacity of large-scale renewable energy power base including wind farms and PV generations increases, the stochasticity, intermittent and fluctuating characteristics of new energy output have a violent impact on grid operation, planning and scheduling. In order to solve these …

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Uptake of arsenic(V) using iron and magnesium functionalized highly ordered mesoporous MCM-41 (Fe/Mg-MCM-41) as an effective adsorbent

Yanqing Song, Ping Huang, Hong Li, Ruiyue Li et autres

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