Jun Nagai

Astrocyte engineering

Minami Motoyoshi, Jun Nagai

Tiling across the central nervous system, astrocytes contact synapses, blood vessels and other glial cells through highly specialised processes, allowing them to regulate local brain environments across multiple spatial and temporal scales. These anatomical and signalling features make astrocytes attractive substrates for …

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Compensatory activation of the deltoid and remaining rotator cuff muscles in patients with rotator cuff tears using real-time tissue elastography

Kyosuke Hoshikawa, R Oishi, Takuma Yuri, Tomohiro Uno et autres

INTRODUCTION: Rotator cuff (RC) tears are a prevalent condition leading to dysfunction and shoulder pain. Spatial changes in the behavior of the deltoid and remaining RC muscles during arm elevation in patients with RC tears have not been investigated. The purpose of …

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Successful prosthesis salvage using continuous local antibiotic perfusion for prosthetic joint infection following revision total elbow arthroplasty in a patient with rheumatoid arthritis

Risa Arai, Yuya Takakubo, Juji Ito, Tomohiro Uno et autres

INTRODUCTION: Prosthetic joint infection (PJI) represents a serious and challenging complication in a patient with rheumatoid arthritis. We report a case of PJI following revision total elbow arthroplasty with rheumatoid arthritis that was successfully managed with debridement, antibiotics, and implant retention augmented …

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The astrocytic ensemble acts as a multiday trace to stabilize memory

Ken‐ichi Dewa, Kodai Kaseda, H. Kubotera, Ayato Yamasaki et autres

Abstract Recalled memories become transiently labile and require stabilization 1–3 . The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear 4 . Here we identify an astrocytic ensemble that is transcriptionally primed by emotional …

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Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders

Wei Lin, Zhongfei Bai, Yu‐Wei Ge, Yuanjie Xiao et autres

Patients with an ischemic stroke are often predisposed to emotional disorders. However, the mechanisms underlying post-stroke emotional disorders (PSEDs) remain unclear. Recent research highlights the role of neuroinflammation, driven primarily by infiltration of circulating immune cells within the brain parenchyma and accompanied …

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Highly deep quantitative proteomics elucidate the mechanism of Alzheimers’ disease targeting reactive astrocyte

Yuki Maeda, Masashi Kawami, Y. Abe, Hiroshi Shimizu et autres

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Quantitative proteomics-based identification of novel thrapeutic targets for progressive supranuclear palsy using post-mortem human brain

Yuta Kumagai, Masashi Kawami, Hiroshi Shimizu, Jun Nagai et autres

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Bilateral vocal cord paralysis following ventriculoatrial shunt placement for hydrocephalus after subarachnoid hemorrhage: illustrative case

Kensuke Ikeda, Shoko Fujii, Keisuke Maruyama, Hiroki Yoshida et autres

BACKGROUND: A ventriculoatrial (VA) shunt is an alternative to a ventriculoperitoneal (VP) shunt for managing hydrocephalus, especially when VP shunt insertion is not feasible. Despite its decline in use, the VA shunt remains vital for certain patients. This report highlights a rare …

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Astrocytes contribute to signals of Hyperpolarized 13C pyruvate in the brain

Maiko Ono, Bolati Wulaer, Tomoteru Yamasaki, Toshihiro Sakamoto et autres

Motivation: Hyperpolarized MR (HP-MR) 13C pyruvate is a valuable probe for evaluating glycolytic flux, but it remains unknown which cells contribute to the HP-MR signals in the brain. Goal(s): To verify whether astrocyte metabolism is involved in the signal of HP-MR 13C …

Usefulness of Three-dimensional Computer Graphics for the Direct Surgery of Ruptured Aneurysms in Deep Collateral Arteries Arising after Indirect Revascularization for Moyamoya Disease: Report of Two Cases

Jun Nagai, Keisuke Maruyama, Yuta Sasaki, Ryo Hatanaka et autres

Treating ruptured aneurysms in deep collateral arteries in moyamoya disease is difficult. Two cases of intracranial hemorrhage due to ruptured aneurysms in the deep collateral vessels after indirect revascularization for moyamoya disease were treated via direct surgery with the assistance of surgical …

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Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation

Ken‐ichi Dewa, Nariko Arimura, Wataru Kakegawa, Masayuki Itoh et autres

In the central nervous system, astrocytes enable appropriate synapse function through glutamate clearance from the synaptic cleft; however, it remains unclear how astrocytic glutamate transporters function at peri-synaptic contact. Here, we report that Down syndrome cell adhesion molecule (DSCAM) in Purkinje cells …

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Homeostasis to Allostasis: Prefrontal Astrocyte Roles in Cognitive Flexibility and Stress Biology

Bolati Wulaer, M Holtz, Jun Nagai

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