Wanrui Wu

Competitive myopia: Predatory competition undermines patience

Ermo Chen, Yunshu Hu, Wanrui Wu

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Global Mapping of Temperature-Health Risks: A Model of AI for Planetary Health

Junji Cao, Ermo Chen, Peng Chen, Xi CHEN et autres

Temperature anomalies drive substantial excess mortality, yet existing early warning systems remain limited to regional scales, reliant on linear assumptions, and fail to adequately account for multi-dimensional thermal stress and socioeconomic heterogeneity. This study develops the Planetary Health Axis System–Meteorology (PHAS–M), a …

ChemKG-QA: Construction of a Knowledge Graph for Chemical Science Popularization and its Application in an Intelligent Question Answering System

T.B. Li, Enhao Zhou, Yanyu Zhang, Wanrui Wu et autres

The advancement of Artificial Intelligence has introduced transformative changes to educational paradigms. However, the abstract nature and vast scope of chemical knowledge in science popularization often lead to fragmented understanding and low engagement among learners. In this study, we introduce knowledge graph …

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The risk of endovascular thrombectomy in acute ischemic stroke patients with large vessel occlusions harboring unruptured intracranial aneurysms

Yinyin Ye, Weili Chen, Zhenxiao Chai, Xia Zhang et autres

BACKGROUND AND PURPOSE: Endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with large vessel occlusions (LVO) has significantly improved over the past decade. Unruptured intracranial aneurysms (UIAs) can potentially increase the risk of hemorrhage during EVT procedures. Given that limited data exist …

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Poly (β-amino esters)/Mobil Composition of Matter 41-mediated delivery of siIL-1β alleviates deep vein thrombosis in rat hind limbs

Bingru Zheng, Jinjie Chen, Yizhou Xu, Wanrui Wu et autres

Introduction: Deep vein thrombosis (DVT) is a major cause of cardiovascular disease-related deaths worldwide and is considered a thrombotic inflammatory disorder. IL-1β, as a key promoter of venous thrombus inflammation, is a potential target for DVT treatment. Constructing a nanocarrier system for …

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Prognostic prediction using a gene signature developed based on exhausted T cells for liver cancer patients

Yu Zhou, Wanrui Wu, Wei Cai, Dong Zhang et autres

Background Liver hepatocellular carcinoma (LIHC) is a solid primary malignancy with poor prognosis. This study discovered key prognostic genes based on T cell exhaustion and used them to develop a prognostic prediction model for LIHC. Methods SingleR's annotations combined with Seurat was …

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Nano hydrogel-based oxygen-releasing stem cell transplantation system for treating diabetic foot

Liangmiao Chen, Bingru Zheng, Yizhou Xu, Changzheng Sun et autres

The employment of stem cells and hydrogel is widespread in contemporary clinical approaches to treating diabetic foot ulcers. However, the hypoxic conditions in the surrounding lesion tissue lead to a low stem cell survival rate following transplantation. This research introduces a novel …

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RETRACTED: A novel therapeutic strategy of combined camrelizumab and apatinib for the treatment of advanced hepatocellular carcinoma

Qing Yang, Gengyu Li, Xiaoqiu Wu, Haiying Lin et autres

Methods: 83 patients with hepatocellular carcinoma (HCC) admitted to the interventional oncology department were randomly divided into two groups. Apatinib and camrelizumab were administered to 42 patients in group A, whereas sorafenib was administered to 41 patients in group B for three …

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A stemness-based eleven-gene signature correlates with the clinical outcome of hepatocellular carcinoma

Liang Hong, Yu Zhou, Xiangbang Xie, Wanrui Wu et autres

BACKGROUND: Cumulative evidences have been implicated cancer stem cells in the tumor environment of hepatocellular carcinoma (HCC) cells, whereas the biological functions and prognostic significance of stemness related genes (SRGs) in HCC is still unclear. METHODS: Molecular subtypes were identified by cumulative …

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Expression of serum miRNAlet-7a in patients with renal clear cell carcinoma and its significance

Qun Song, Wanrui Wu

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TIPE2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Prostate Cancer Cells by Inhibiting PI3K/Akt Signaling Pathway

Qiang Lü, Zhe Liu, Zhuo Li, Jia Chen et autres

Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TNFAIP8L2, TIPE2) is involved in the invasion and metastasis of human tumors. However, the functional role of TIPE2 in prostate cancer remains unclear. In the present study, we explored the role of TIPE2 in prostate …

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Clinical study of flexible uroteroscope holmium lithotripsy for the treatment of upper urethral calculus associated renal insufficicncy

Yuanwei Li, Wanrui Wu, Zhe Liu

Objectives To evaluate the efficacy and safety of flexible ureteroscopic holmium laser lithotripsy for proximal ureteral calculi in the patients with renal insufficiency.Methods Between December 2012 and February 2014,A total of 19 patients,with a mean age of 55 years (range 28 ～72),underwent …

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