Nicole Wieghard

Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) trial: a protocol for a pragmatic randomised study of diverticulitis treatment in the USA

Mariam N. Hantouli, Robert H. Schmicker, Janice E Tufte, Fadwa Ali et autres

INTRODUCTION: Each year, millions of people experience recurrent diverticulitis episodes. Elective sigmoid colon resection reduces the risk of recurrence, but The American Society of Colon and Rectal Surgeons recommends individualising surgical decisions based on the impact of the condition on a patient's …

us (code pays fourni par la source)

Local and National Trends in Emergency Presentation of Colon and Rectal Cancer

Alyssa Habermann, Lukas Jyuhn‐Hsiarn Lee, Sarah Martey, Stacy Ranson et autres

AIM: Emergent diagnosis of colorectal cancer is associated with increased postoperative complications and poorer prognosis. We assessed the rate of emergent presentation of colorectal cancer at our institution, identified risk factors for emergent presentation, and compared our results to national data. METHODS: …

us (code pays fourni par la source)

Trends in surgical outcomes for Ileal pouch–anal anastomosis construction using a large nationwide database

Alyssa Habermann, Hannah E. Gassie, Salem Rustom, Nicole Wieghard et autres

AIM: Ulcerative colitis (UC) affects over 3 million (1.3%) US adults, approximately 20% of whom will require surgery. Since it was first described in 1978, restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the gold standard for patients requiring surgery, as …

us (code pays fourni par la source)

A mixed methods exploration of the emergence of goal orientation in medical students’ individualized learning plans

Ashlie Tseng, Cherie Edwards, Meagan Rawls, Melissa J. McGinn et autres

PURPOSE: Goal orientation (GO) describes an individual's approach to different achievement situations. Understanding the motivations and approach to achieving goals of medical students is vital with the increasing emphasis on self-directed learning. The purpose of this study was to identify themes in …

us (code pays fourni par la source)

Virtual Ileostomy as an Option for Complicated Colorectal Resections

Yahya Alwatari, McKenzie G. Lee, Nicole Wieghard, Jaime L. Bohl

When surgery requires a colorectal anastomosis, a diverting ostomy may be created to decrease the clinical impact of anastomotic failure. Unfortunately, diverting ileostomies are also associated with significant morbidity. Recent literature suggests that diverting ostomies are not necessary for the majority of …

us (code pays fourni par la source)

The Difficulty of Distal Crohn’s Disease and the Utility of Diverting Stomas

Nicole Wieghard

Despite advances in Crohn’s disease (CD) management in the era of biologic therapy, perianal and distal CD remain challenging. Perianal fistulizing disease, which affects up to one-third of patients with CD, is often refractory to biologic therapy.1 Surgical options also remain limited, …

us (code pays fourni par la source)

Are the current colonoscopy recommendations for interval surveillance in patients with polyps enough? Machine learning-augmented propensity score cohort analysis of 1840 patients

Sarah Baker, Dominique Monlezun, Nicole Wieghard, Charles B. Whitlow et autres

us (code pays fourni par la source)

Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal Neoplasia

Brett S. Walker, Luai Zarour, Nicole Wieghard, Alexandra C. Gallagher et autres

BACKGROUND: Colorectal cancer (CRC) ranks second in cancer deaths worldwide and presents multiple management challenges, one of which is identifying high risk stage II disease that may benefit from adjuvant therapy. Molecular biomarkers, such as ones that identify stem cell activity, could …

us (code pays fourni par la source)

Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn’s Disease

Chao Li, John R. Grider, Karnam S. Murthy, Jaime L. Bohl et autres

BACKGROUND: Endoplasmic reticulum (ER) stress is an essential response of epithelial and immune cells to inflammation in Crohn's disease. The presence and mechanisms that might regulate the ER stress response in subepithelial myofibroblasts (SEMFs) and its role in the development of fibrosis …

us (code pays fourni par la source)

MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis

Katherine A. Kelley, Nicole Wieghard, Yuki Chin, Amiee Potter et autres

BACKGROUND: MicroRNAs are dysregulated in colorectal cancer and subsets correlated with advanced tumor stage and metastasis. Data are lacking on microRNA dysregulation from early to late-stage disease. OBJECTIVE: The purpose of this study was to identify a microRNA signature associated with the …

us (code pays fourni par la source)

Prognosis of small bowel adenocarcinoma in Crohn's disease compares favourably with de novo small bowel adenocarcinoma

Nicole Wieghard, Solange Mongoue‐Tchokote, John Young, Brett C. Sheppard et autres

AIM: Limited data exist on Crohn's disease (CD)-associated small bowel adenocarcinoma (SBA). A large-scale retrospective cohort study was conducted comparing the clinical features and outcome of CD-associated SBA and de novo SBA. METHOD: Data for patients with small bowel adenocarcinoma were gathered …

us (code pays fourni par la source)

Treatment and Survival of Small-bowel Adenocarcinoma in the United States

John Young, Solange Mongoue‐Tchokote, Nicole Wieghard, Motomi Mori et autres

BACKGROUND: Small-bowel adenocarcinoma is rare and fatal. Because of data paucity, there is a tendency to extrapolate treatment from colon cancer, particularly in the adjuvant stetting. OBJECTIVE: The purpose of this study was to evaluate the current surgical and adjuvant treatments of …

us (code pays fourni par la source)