Tomás Huerta

Calcium Transient Kinetics of Vagal Sensory Neuron Responses to Inflammatory Cytokines

Timothy Morgan, Aditya Shah, Kicheon Park, Tomás Huerta et autres

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Vagal TRPV1 + sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics

Nicole Almanzar, Daping Yang, Jingya Xia, Swalpa Udit et autres

Influenza viruses are a major global cause of morbidity and mortality. Although vagal TRPV1 + nociceptive sensory neurons are known to mediate defenses against harmful agents, including pathogens, their function in lung antiviral defenses remains unclear. Our study demonstrates that both systemic …

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Dysregulated neural coding in the vagus nerve during long sepsis

Joshua J. Strohl, Tomás Huerta, Sergio Robbiati, Patricio T. Huerta

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from the body's unbalanced and excessive response to an infection. 'Long sepsis' (LS) is an emerging concept referring to persistent sequelae experienced by long-term sepsis survivors, which include cognitive impairment, immune dysfunction, …

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Neural representation of cytokines by vagal sensory neurons

Tomás Huerta, Adrian C. Chen, Saher Chaudhry, Aisling Tynan et autres

The nervous system coordinates with the immune system to detect and respond to harmful stimuli. Inflammation is a universal response to injury and infection that involves the release of cytokines. While it is known that information about cytokines is transmitted from the …

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143 Individual Vagus Nerve Sensory Neurons Respond Distinctly to Specific Pro-inflammatory Cytokines

Tomás Huerta, Adrian Chen, Eric H. Chang

INTRODUCTION: The peripheral nervous system (PNS) communicates with the immune system in response to injury or infection. In the case of inflammation, sensory signals travel up to the brain via the vagus nerve, which is a major pathway for neuro-immune communication. While …

137 Light-mediated Vagus Nerve Stimulation Inhibits Pro-inflammatory Cytokine Production in Acute Endotoxemia

Adrian Chen, Tomás Huerta, Saher Chaudhry, Eric H. Chang

INTRODUCTION: Vagus nerve stimulation (VNS) is a form of neuromodulation being explored to treat chronic inflammatory conditions by activating the inflammatory reflex, an arc reducing proinflammatory cytokine release through efferent cholinergic signaling. Current VNS approaches are primarily invasive and use electricity, but …

IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models

Javiera Arcos, Felipe Grünenwald, Denisse Sepúlveda, Carolina Jerez et autres

Parkinson's disease (PD) is the second most common late-onset neurodegenerative disease and the predominant cause of movement problems. PD is characterized by motor control impairment by extensive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). This selective dopaminergic neuronal …

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The Fifth Bioelectronic Medicine Summit: today’s tools, tomorrow’s therapies

Eric H. Chang, Arielle Gabalski, Tomás Huerta, Timir Datta et autres

The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment of several neurological and inflammatory disorders. With several BEM therapies being recently approved for clinical use and others in late-phase clinical trials, the 2022 BEM …

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Calcium imaging and analysis of the jugular-nodose ganglia enables identification of distinct vagal sensory neuron subsets

Tomás Huerta, Bilal Haider, Richard Adamovich‐Zeitlin, Adrian C. Chen et autres

Abstract Objective. Sensory nerves of the peripheral nervous system (PNS) transmit afferent signals from the body to the brain. These peripheral nerves are composed of distinct subsets of fibers and associated cell bodies, which reside in peripheral ganglia distributed throughout the viscera …

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Optimal Preparation of Adipose Tissue in Frozen Sections for Mohs Micrographic Surgery

Tomás Huerta, Alison M. Bailey, Jarrett Bergin, Joel Cook

Huerta, Tomas MD; Bailey, Alison MD; Bergin, Jarrett BA; Cook, Joel MD Author Information

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Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses

Harold Silverman, Aisling Tynan, Tyler D. Hepler, Eric H. Chang et autres

BACKGROUND: Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate sensory neurons (nociceptors) to mediate the onset of pain, sickness behavior, and metabolic responses. Although …

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Current evidence does not support Mohs micrographic surgery or staged excision as equivalent to wide excision for primary cutaneous melanoma

Tomás Huerta, Susan M. Swetter, Kishwer S. Nehal, Daniel G. Coit et autres

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