Naoko Yoshizawa-Sugata

Linker dependence of ¹O₂ generation by G4-binding tetra-imidazolium porphyrins

Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee et autres

Three water-soluble porphyrins with tetracationic imidazolium groups were synthesized and assessed for complexation with human telomeric guanine-quadruplex (G4) DNA. Based on UV-vis titration studies, these porphyrins showed 10-fold higher complexation stability toward G4 DNA over non-G4 DNA. This was consistent with FRET …

Water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines for G4-targeting photodynamic therapy

Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee et autres

Porphyrins are well-known photosensitizers (PSs), a few of which are clinically approved drugs for use in photodynamic therapy (PDT). Porphyrin derivatives including tetra-cationic porphyrins, e.g.TMPyP4, are also well-studied binders for G-quadruplex (G4) DNA. Since G4 DNAs are known to play a role …

Linker dependence of 1 O 2 generation by G4-binding tetra-imidazolium porphyrins

Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Hwa Lee et autres

generation was enhanced. Cellular internalization of these porphyrins was observed by flow cytometry, resulting in sufficient photocytotoxicity of these porphyrins toward both cancer cells (HeLa) and normal cells (NHDF). Photocytotoxicity to a cancer cell line was higher than that to normal cells. …

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Water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines for G4-targeting photodynamic therapy

Naoko Kakusho, Sung Sik Lee, Naoko Yoshizawa-Sugata, Hisao Masai et autres

in line with photoinduced DNA cleavages. Studies in a cancer cell line (HeLa) and a normal fibroblast (NHDF) cells revealed significantly stronger photocytotoxicities of these porphyrins (1 and 2) in comparison to TMPyP4, presumably due to better cellular internalization - as observed …

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Author response for "Water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines for G4-targeting photodynamic therapy"

Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee et autres

The spatial transcriptome of the late-stage embryonic and postnatal mouse brain reveals spatiotemporal molecular markers

Yuichiro Hara, Takuma Kumamoto, Naoko Yoshizawa-Sugata, Kumiko Hirai et autres

The neocortical development process includes cell proliferation, differentiation, migration, and maturation, supported by precise genetic regulation. To understand these processes at the cellular and molecular levels, it is necessary to characterize the fundamental anatomical structures by gene expression. However, markers established in …

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Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques

Alessandro Fracassi, Hui Qiao, Andrew N. Lowell, Jianbo Cao et autres

High Resolution Image Download MS PowerPoint Slide Low-density lipoprotein (LDL) is the primary natural carrier of lipids in the bloodstream and plays a central role in the development of atherosclerosis. By leveraging LDL’s natural tendency to accumulate at sites of plaque formation, …

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Water-Soluble Mn(III)-Porphyrins with High Relaxivity and Photosensitization

Tamás Németh, Agnès Pallier, Zoltán Garda, Naoko Yoshizawa-Sugata et autres

High Resolution Image Download MS PowerPoint Slide Three water-soluble Mn(III)-porphyrin complexes with cationic pyridyl side groups bearing COOH- or OH-terminated carbon chains in the meta or para positions have been synthesized as probes for both magnetic resonance imaging (MRI) and photodynamic therapy …

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Water-Soluble Gd(III)–Porphyrin Complexes Capable of Both Photosensitization and Relaxation Enhancement

Tamás Németh, Naoko Yoshizawa-Sugata, Agnès Pallier, Youichi Tajima et autres

High Resolution Image Download MS PowerPoint Slide With the aim of developing more stable Gd(III)–porphyrin complexes, two types of ligands 1 and 2 with carboxylic acid anchors were synthesized. Due to the N-substituted pyridyl cation attached to the porphyrin core, these porphyrin …

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Spatial transcriptome of developmental mouse brain reveals temporal dynamics of gene expressions and heterogeneity of the claustrum

Yuichiro Hara, Takuma Kumamoto, Naoko Yoshizawa-Sugata, Kumiko Hirai et autres

ABSTRACT During the development of the mammalian cerebral cortex, numerous neurons are arranged in a six-layer structure with an inside-out fashion to form the neocortex and wire neural circuits. This process includes cell proliferation, differentiation, migration, and maturation, supported by precise genetic …

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Histone Modification Analysis of Low-Mappability Regions

Naoko Yoshizawa-Sugata, Hisao Masai

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Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation

Naoko Yoshizawa-Sugata, Satoshi Yamazaki, Kaoru Mita-Yoshida, Tomio Ono et autres

Rif1 regulates DNA replication timing and double-strand break repair, and its depletion induces transcriptional bursting of two-cell (2C) zygote-specific genes in mouse ES cells. However, how Rif1 regulates zygotic transcription is unclear. We show here that Rif1 depletion promotes the formation of …

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