Chrysanthi Iliadi

Immuno-radiotherapy enhances tumor control and induces abscopal responses in a humanized mouse model

Morgane M. Cogels, Matteo Serra, Hugues Duvillier, Soizic Garaud et autres

Introduction: Radiation therapy (RT) offers a tool to enhance immune checkpoint inhibitor (ICI) efficacy, yet its immunomodulatory potential remains poorly understood. Here, we investigated how RT dose-fractionation regimens shape local and systemic antitumor immunity. Methods: A hematopoietic stem cell-humanized NOG mouse model …

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Immuno-Radiotherapy Enhances Tumor Control and Induces Abscopal Responses in a Humanized Mouse Model

Sébastien Penninckx, Morgane M. Cogels, Matteo Serra, Hugues Duvillier et autres

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APR-246 & COTI-2 increase chemoradiotherapy sensitivity via ROS-induced DNA damage and ferroptosis in p53 mutant HPV negative head and neck squamous cell carcinoma

Tycho de Bakker, Morgane M. Cogels, Chrysanthi Iliadi, Sébastien Penninckx et autres

Abstract About 80% of patients with HPV negative head and neck squamous cell carcinoma are diagnosed at stage III or IV. In these cases, Surgical resection followed by (chemo-)radiotherapy is the standard treatment for most cases. However, many patients present with unresectable …

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The current understanding of the immune landscape relative to radiotherapy across tumor types

Chrysanthi Iliadi, Laurine Verset, Christelle Bouchart, Philippe Martinive et autres

Radiotherapy is part of the standard of care treatment for a great majority of cancer patients. As a result of radiation, both tumor cells and the environment around them are affected directly by radiation, which mainly primes but also might limit the …

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