C. Kooperberg

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

C. Kooperberg, Rachel Mester, David V. Conti, M. Fornage et autres

Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. This offers the unique opportunity of investigating the similarity of genetic effects on traits across ancestries within the same population. …

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Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Lawrence F. Bielak, B.M. Psaty, Juan M. Peralta, R. Graham Barr et autres

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new …

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Mapping and characterization of structural variation in 17,795 human genomes

V. Salomaa, S.S. Rich, Elizabeth L. Appelbaum, Ryan M. Layer et autres

A key goal of whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, including single-nucleotide variants, small insertion or deletion (indel) variants and structural variants. However, tools and resources for the study of structural variants have lagged …

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Genetic discovery and risk characterization in type 2 diabetes across diverse populations

Laura M. Raffield, G.N. Nadkarni, Christopher S. Carlson, H.M. Highland et autres

Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry. We conducted a multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African, Hispanic, Asian, Native …

Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study

L.S. Phillips, S.F. Dimos, S.S. Rich, R. Tao et autres

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Generalization of adiposity genetic loci to US Hispanic women

C. Kooperberg, Sylvia Wassertheil‐Smoller, M. Neuhouser, K. C. Johnson et autres

BACKGROUND:Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown.OBJECTIVE:To interrogate an a priori list of 47 (32 overall body mass and 15 central …

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