G Walker

Letter: Acute Severe Ulcerative Colitis in the Advanced Therapy Era: Is Lowering the CRP Threshold Enough? Authors' Reply

Amirah Etchegaray, Graham Radford‐Smith, G Walker, Anthony Croft et autres

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Editorial on: ‘Lowering the C‐Reactive Protein Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis’. Authors' Reply

Amirah Etchegaray, Naeman Goetz, Katherine Hanigan, Jennifer Phillips et autres

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Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis

Amirah Etchegaray, Naeman Goetz, Katherine Hanigan, J Phillips et autres

BACKGROUND: Real-world data demonstrate that patients hospitalised with non-acute severe UC (NASUC) experience intravenous corticosteroid (IVCS) failure rates approaching those of ASUC, yet no dedicated management guidelines exist. AIMS: We aimed to determine whether inpatient medical therapy and colectomy risk differ between …

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Systematic Review: The Impact of Geographic Location and Socioeconomic Status on Healthcare Utilisation and Clinical Outcomes in Patients With Inflammatory Bowel Disease (IBD) in the Developed World

George Tambakis, Lei Lin, Rina Kumar, Jennifer Ann Phillips et autres

ABSTRACT Background Inflammatory bowel diseases (IBD) are a group of chronic inflammatory conditions affecting the gastrointestinal tract, which requires life‐long management. Healthcare inequalities in IBD are a key factor influencing disease outcomes. Aim This review aimed to describe the impact of geographical …

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Understanding heterogeneity in the pathogenesis and drug responses of ulcerative colitis through single-cell and spatial transcriptomics

Jennifer Ann Phillips, George Tambakis, Rina Kumar, Anthony R. Croft et autres

Introduction: Ulcerative colitis (UC) is driven by mucosal inflammation and epithelial injury. Single cell RNA sequencing (scRNA-seq) enables high resolution profiling of immune, stromal and epithelial compartments in UC, whilst spatial transcriptomic (ST) and proteomic (SP) enable interrogation of cell-cell interactions, niche-specific …

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Triaging colorectal urgent referrals in the COVID-19 era using faecal immunochemical testing: a prospective UK real-world multicentre cohort study

G Walker, Supriya Balasubramanya, Joel M. Bowen, Nedal Debab et autres

OBJECTIVE: During the early COVID-19 pandemic, UK guidelines advocated faecal immunochemical tests (FIT) with a threshold of 10 µg/g to help secondary care clinicians triage urgent suspected colorectal cancer (CRC) referrals. We aimed to evaluate the real-world performance and impact of FIT …

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Clinical Utility and Cost‐Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource

Christopher Roberts, Jaime Peters, Aleksejs Sazonvos, Neil F. Goodman et autres

BACKGROUND: The clinical utility and cost-effectiveness of pre-thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown. AIMS: To report the prevalence, penetrance, expressivity, and pathogenicity of NUDT15 variant allele carriage and the diagnostic accuracy and cost-effectiveness of an inexpensive loop-mediated …

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Inflammatory Bowel Disease Clinical Activity is Associated with COVID-19 Severity Especially in Younger Patients

Jean‐Frédéric Colombel, Ryan C. Ungaro, Shaji Sebastian, Michael D. Kappelman et autres

BACKGROUND AND AIMS: Age is a major prognostic factor for COVID-19 outcomes. The effect of inflammatory bowel disease [IBD] activity on COVID-19 is unclear. We examined the relationship between IBD activity and COVID-19 severity according to age. METHODS: We included IBD patients …

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Mo1954: CONSISTENCY AND QUALITY OF INFLAMMATORY BOWEL DISEASE CARE IN AUSTRALASIA; TOWARDS BENCHMARKING.

Wai Kin Su, Jack McNamara, William Edward Wilson, Gabrielle Wark et autres

Mo1891: IRON DEFICIENCY, WITH OR WITHOUT ANAEMIA, IN INFLAMMATORY BOWEL DISEASE REMAINS AN UNDERMANAGED ISSUE: CROHN’S COLITIS CURE DATA INSIGHTS PROGRAM

Brigid C. Pinnuck, Wai Kin Su, William Edward Wilson, Joseph Louis Pipicella et autres

Tu1094: PATTERNS AND PREDICTORS OF STEROID USE IN PEOPLE WITH IBD IN ROUTINE CARE ACROSS ANZ

Consuelo Rivas, Wai Kin Su, William Edward Wilson, Watson Ng et autres

Sa1917: CORTICOSTERIOD AND OPIATE USE IN INFLAMMATORY BOWEL DISEASE, 25 YEARS AFTER THE CROHN’S THERAPY, RESOURCE, EVALUATION, AND ASSESSMENT TOOL (TREAT) WAS ESTABLISHED

Brigid C. Pinnuck, Wai Kin Su, William Edward Wilson, Joseph Louis Pipicella et autres