Xiaoxuan Bai

CIITA/PRMT5 promote CD4+Gzma+ T cell activation via H3R2me2-mediated endothelial expression of MHC class II in smoking-induced atherosclerosis

Yuwu Chen, Xing Luo, Biyi Xu, Xinxin Zhu et autres

Smoking is considered as the major risk factor for the progression of atherosclerosis (AS), whereas the underlying immunological mechanism remains unclear. ApoE KO mice were treated with cigarette tar via inhalation in vivo, mouse arterial endothelial cells (MAECs) and human coronary artery …

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Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism

Xing Luo, Xinxin Zhu, Yuwu Chen, Yiyuan Guo et autres

Endothelial progenitor cells (EPCs) derived extracellular vesicles (EVs) are involved in maintaining vascular homeostasis, while effects of hypoxic preconditioned EPCs-derived EVs (Hy-EVs) on atherosclerosis (AS) remain unclear. Hy-EVs and normal oxygen EVs (N-EVs) were pretreated for ApoE −/− mice and ox-LDL treated …

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Quercetin alleviates postmenopausal atherosclerosis by suppressing endothelial cell ferroptosis via regulating the KEAP1/NRF2/GPX4 signalling pathway

Ying Lv, Xiuzhu Weng, Yuxiao Zhu, Xinyi Zhang et autres

BACKGROUND AND PURPOSE: Postmenopausal women experience accelerated progression of atherosclerosis, yet the underlying mechanisms remain poorly understood and effective therapeutic strategies are limited. This study aimed to investigate the protective effects of quercetin (QCT) against postmenopausal atherosclerosis and to elucidate its mechanism …

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Targeting KEAP1/NRF2 interaction with oleuropein ameliorates atherosclerosis by inhibiting macrophage ferroptosis

Xinxin Zhu, Yuwu Chen, Biyi Xu, Junke Mou et autres

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Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA

Xing Luo, Ji Li, Yuwu Chen, Xiuzhu Weng et autres

Smoking is the only cardiovascular risk factor for plaque erosion. We found cigarette tar resulted in erosion-like lesion development in apolipoprotein E−/− mice, with mural thrombosis, discontinuous endothelium, platelet activation, smooth muscle cell proliferation, and hyaluronic acid accumulation in the aorta. Single-cell …

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Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque

Yuwu Chen, Biyi Xu, Quan Lin, Xinxin Zhu et autres

Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to the progression of atherosclerosis (AS). Meanwhile, Spermine (Sp) could serve as an endogenous small molecule exhibiting a wide range of cardiovascular protective effects. Zeolitic imidazolate framework-90 (ZIF90) nanoparticles were …

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Plaque erosion risk and JAK2 V617F variant

Shengfang Wang, Xing Luo, Sining Hu, Chen Zhao et autres

BACKGROUND AND AIMS: Clonal haematopoiesis of indeterminate potential (CHIP) can increase the risk of myocardial infarction (MI). Among various CHIP mutations, JAK2 V617F substantially elevated this risk. However, the specific associations between JAK2 V617F and two mechanisms of MI, plaque erosion and …

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Non-culprit plaque healing on serial OCT imaging and future outcome in patients with acute coronary syndromes

Boling Yi, Luping He, Dirui Zhang, M. Zeng et autres

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Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells

Xiaoxuan Bai, Ying Wang, Xing Luo, Xiaoyi Bao et autres

Abstract Background Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate …

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Corrigendum to “MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction” [Redox Biol. 69 (2024) 102987]

Xing Luo, Yuehong Wang, Xinxin Zhu, Yuwu Chen et autres

The authors realized that the quantization diagram of the present manuscript Fig. 1J and supplemental Fig. 15D had been incorrectly placed, and Fig. 7E had been incorrectly labeled.Therefore, we request a correction to Fig. 1J, supplemental Fig. 15D and Fig. 7E in …

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MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction

Xing Luo, Yuehong Wang, Xinxin Zhu, Yuwu Chen et autres

Micheliolide (MCL), also known as ACT001, which is the active metabolite of parthenolide, has demonstrated promising clinical application potential. However, the effects and underlying mechanisms of MCL on atherosclerosis are still unclear. ApoE−/− mice were fed with high fat diet, with or …

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Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF‐κB pathway and ameliorates atherosclerosis

Xiuzhu Weng, Xing Luo, Xinyu Dai, Ying Lv et autres

Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits various bioactivities, particularly anti-inflammation, but its effect on pyroptosis remains unclear. The aim of this study is to investigate the effect of apigenin on pyroptosis and …

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