D Beral

Incisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART)

Jared Torkington, Rhiannon Harries, Susan O’Çonnell, Laura Knight et autres

BACKGROUND: Incisional hernias cause morbidity and may require further surgery. HART (Hughes Abdominal Repair Trial) assessed the effect of an alternative suture method on the incidence of incisional hernia following colorectal cancer surgery. METHODS: A pragmatic multicentre single-blind RCT allocated patients undergoing …

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Colorectal Endoscopic Stenting Trial (CReST) for obstructing left-sided colorectal cancer: randomized clinical trial

James Hill, S Lee, Dion Morton, M. C. Parker et autres

BACKGROUND: Colorectal cancer often presents with obstruction needing urgent, potentially life-saving decompression. The comparative efficacy and safety of endoluminal stenting versus emergency surgery as initial treatment for such patients is uncertain. METHODS: Patients with left-sided colonic obstruction and radiological features of carcinoma …

Defining core patient descriptors for perforated peptic ulcer research: international Delphi

Segun Lamidi, Kate Williams, Daniel Hind, Adam Peckham-Cooper et autres

BACKGROUND: Perforated peptic ulcer (PPU) remains a common condition globally with significant morbidity and mortality. Previous work has demonstrated variation in reporting of patient characteristics in PPU studies, making comparison of studies and outcomes difficult. The aim of this study was to …

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289Birthweight and risks of adult-onset diabetes in women who are and are not overweight

Md Shajedur Rahman Shawon, TienYu Owen Yang, Sarah Floud, Jane Green et autres

Abstract Background Higher adult body mass index (BMI) increases diabetes risk, whereas, paradoxically, lower birthweight is associated with higher risks of adult-onset diabetes. Increased diabetes risks associated with low birthweight might be due to increased risks among those who become overweight or …

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Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study

Dmitri Nepogodiev, Richard Wilkin, Catherine J. Bradshaw, Clare Skerritt et autres

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Effects of obesity and hormone therapy on surgically-confirmed fibroids in postmenopausal women

Eva Sommer, Angela Balkwill, Gillian Reeves, Jane Green et autres

To examine the association between body mass index (BMI), use of menopausal hormone therapy (HT), and incidence of uterine fibroids in postmenopausal women, 610,604 postmenopausal women without prior hysterectomy or diagnosis of fibroids were followed as part of a large United Kingdom …

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Outcome of appendicectomy in children performed in paediatric surgery units compared with general surgery units

SG Tiboni, Aneel Bhangu, NJ Hall, N. Chatzizacharias et autres

BACKGROUND: Appendicectomy for acute appendicitis in children may be performed in specialist centres by paediatric surgeons or in general surgery units. Service provision and outcome of appendicectomy in children may differ between such units. METHODS: This multicentre observational study included all children …

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