Sisi Ling

Targeting STX4-dependent HNRNPA2B1 degradation to suppress neointimal hyperplasia

Xiaolin Liu, Rongxue Li, Canshan Chen, Zhiwei Gao et autres

Construction of β-Heteroarylated Aliphatic Aldehydes via Pd-Catalyzed and Ag-Mediated Redox-Relay Oxidative Heck Reactions

Junxiang Liu, 苟练, Tao Sun, Xianhui Yang et autres

Herein, we report the first example of Pd-catalyzed and Ag-mediated redox-relay oxidative Heck reactions of furans/thiophenes with cis-alkenols to construct β-heteroarylated aliphatic aldehydes. Parallel kinetic isotope effect (KIE) experiments reveal that C-H bond breaking of the heterocycle might be involved in the …

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Bright, Biocompatible NIR-II-Emitting I–VI Quantum Dots for Rapid Disease Diagnosis

Sisi Ling, Xiaohu Yang, Hongchao Yang, Chang Li et autres

Rapid diagnostic technology serves as a cornerstone of clinical medicine, playing an essential role in the early detection of major diseases and the development of personalized treatment strategies. The complexity and diversity of clinical diagnostic needs impose increasingly stringent demands on the …

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Micron-Scale 2D Antibody Arrays for HER2 Signaling Blockade and Cancer Therapy

Mingming Du, Xiang Zhong, Tingfeng Yao, Xiangyu Wu et autres

Monoclonal antibodies (mAbs) targeting the human epidermal growth factor receptor 2 (HER2) are widely used in the treatment of breast, gastric, and other solid tumors. However, rapid HER2 endocytosis and recycling contribute to low response rates and treatment resistance. Here, we introduce …

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Intraoperative tumor margin delineation using a hybrid cyanine–rhodamine NIR-II fluorescent probe

Chunyan Li, Chuyu Li, Sisi Ling, Xingyu Wang et autres

visualization and fluorescence-guided resection of orthotopic and peritoneal breast tumors. Compared to the ICG-cRGD control, SulfoHCR7-cRGD demonstrated significantly enhanced tumor fluorescence, sharper tumor boundaries, and a higher signal-to-background ratio. These merits enabled clear localization and delineation of tumor tissues, making it a …

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Long-acting multiple programmed cell death nanoinducers based on polyunsaturated fatty acid supplemented liposomal photosensitizers for enhanced photodynamic immunotherapy

Yu Hao, Minming Chen, Yunyun Zhang, Hongchao Yang et autres

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Lattice‐Engineered Lanthanide Nanocrystals with Tunable Near‐Infrared‐IIb Lifetime

Feng Wu, Sisi Ling, Yejun Zhang, Chunyan Li et autres

Abstract Lattice engineering in lanthanide nanocrystals (LnNCs) is fundamental for tailoring their versatile optical properties, yet it remains underexplored in manipulating the downconversion characteristics. Here, we engineer the lattices from distorted to strain‐graded in LnNCs by CaF2 deposition on vacancy‐controlled β‐NaxGdF3+x:Yb,A (A …

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Lattice‐Engineered Lanthanide Nanocrystals with Tunable Near‐Infrared‐IIb Lifetime

Feng Wu, Sisi Ling, Yejun Zhang, Chunyan Li et autres

Abstract Lattice engineering in lanthanide nanocrystals (LnNCs) is fundamental for tailoring their versatile optical properties, yet it remains underexplored in manipulating the downconversion characteristics. Here, we engineer the lattices from distorted to strain‐graded in LnNCs by CaF2 deposition on vacancy‐controlled β‐NaxGdF3+x:Yb,A (A …

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Tumor Microenvironment-Responsive Nano-Immunomodulators for Enhancing Chimeric Antigen Receptor-T Cell Therapy in Lung Cancer

Qian Chen, Jie Sun, Sisi Ling, Hongchao Yang et autres

Chimeric antigen receptor (CAR)-T cells have shown unparalleled efficacy in treating hematologic cancers, but their application in solid tumor treatment remains challenging due to the immunosuppressive tumor microenvironment (TME). It is highly significant to develop safe and efficient TME regulatory strategies for …

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Manganese Ions Chelated Tumosomes as Autologous Cancer Nanovaccines for Effective Suppression of Postsurgical Tumor Relapse

Minming Chen, Hao Yu, Sisi Ling, Hongchao Yang et autres

Autologous cancer vaccines represent a promising strategy to effectively suppress postoperative tumor relapse by eliciting tumor-specific immune responses that highly rely on the efficient internalization and lymph node-targeting delivery of vaccines. Herein, we report an autologous nanovaccine obtained by sequentially incorporating tumor …

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Revealing the energy transfer between NIR-II PEGylated quantum dots and water

Mingzhe Wang, Sisi Ling, Ziyan Zhang, Yejun Zhang et autres

We have developed a hydrophobic alkyl chain-modified PEG to functionalize NIR-II Ag 2 S(Ag 2 S-C 11 -PEG) QDs, effectively suppressing energy transfer from the QDs to water and achieving a three-fold enhancement in photoluminescence intensity.

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Tuning the energetics of carbonyl-bridged triarylamines: from thermally activated delayed fluorescence to anti-Kasha dual-emission and room temperature phosphorescence materials

Liqiu Wan, Sisi Ling, Lei Yang, Bijin Li

The first example of tuning the energetics of thermally activated delayed fluorescence (TADF) molecules to access anti-Kasha dual-emission and room-temperature phosphorescence materials through a strategy for structural modification is developed here. To rapidly construct a library of structurally diverse carbonyl-bridged triarylamine-based TADF …

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