Matthew G. Lammers

Detection of mecA-mediated methicillin resistance and evaluation of disk-diffusion antimicrobial susceptibility characteristics of Staphylococcus saprophyticus isolates from geographically diverse locations

Jamie Marino, Carol E. Muenks, Matthew G. Lammers, Meghan A. Wallace et autres

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Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus

Kailun Zhang, Robert F. Potter, Jamie Marino, Carol E. Muenks et autres

ABSTRACT Staphylococcus saprophyticus is the leading Gram-positive cause of uncomplicated urinary tract infections. Recent reports of increasing antimicrobial resistance (AMR) in S. saprophyticus warrant investigation of its understudied resistance patterns. Here, we characterized a diverse collection of S. saprophyticus ( n = …

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Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis

Thiago M. A. Santos, Matthew G. Lammers, Maoquan Zhou, Ian L. Sparks et autres

Bacterial cell division requires identification of the division site, assembly of the division machinery, and constriction of the cell envelope. These processes are regulated in response to several cellular and environmental signals. Here, we use small molecule iron chelators to characterize the …

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Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase

Katherine A. Hurley, Thiago M. A. Santos, Molly R. Fensterwald, Madhusudan Rajendran et autres

genes), overexpression of GyrA, GyrB, or GyrA and GyrB together does not suppress the inhibitory effect of the gyramides. These observations support the hypothesis that the gyramides inhibit DNA gyrase using a mechanism that is unique from other known inhibitors.

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Physiology of Enterococcus faecalis and faecium

Matthew G. Lammers

Enterococcus faecium and Enterococcus faecalis are commensal bacteria that colonize the gastrointestinal tract. Although these bacteria are in principal non-pathogenic, E. faecium and E. faecalis have emerged as important nosocomial pathogens with high-level resistance to antibiotics causing clinical infections including urinary tract …