Zholobak Nm

Stability of Biologically Active Human Interferon α-2b in Transgenic “Long-Shelf Life” Tomatoes and Their Progeny

Vladimir A. Rudas, O. O. Ovcharenko, О. M. Yaroshko, Zholobak Nm et autres

Human interferon α-2b (HuIFNα-2b) is a cytokine with antiviral and antiproliferative activities and is widely used as a therapeutic protein. Here, we investigated the production of biologically active HuIFNα-2b in transgenic tomato plants. Long-shelf-life Solanum lycopersicum L. cv. ‘Shedevr 1’ plants were …

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Plant Systems as Platforms for the Production of Interferon Alpha and its Application

O. O. Ovcharenko, Zholobak Nm, Vladimir A. Rudas, Микола Вікторович Кучук

Abstract Interferon alpha (IFN) is a small glycosylated polypeptide used in the treatment of cancer, immune disorders, and various other related diseases. Demands for human and veterinary medicine in safe sources of this remedy motivate investigations for new interferon production systems. Plants …

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In vitro and in vivo regenerative processes resulting from the effect of experimental samples of synthetic polyvinyl formal based hydrogel implants

Yu. M. Samchenko, A. Maletskyi, S. М. Dybkova, Т. Г. Грузина et autres

Purpose: To experimentally examine in vitro and in vivo regenerative processes resulting from the effect of experimental samples of synthetic (poly)vinyl formal (PVF) based hydrogel implants. Material and Methods: Scanning electron microscopy (SEM) analysis; Vero cell culture evaluation of in vitro regenerative …

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A PVP-stabilized cerium oxide–platinum nanocomposite synthesized in TEG: pro-/antioxidant activities

Zholobak Nm, Anastasiia Deineko, Viacheslav Kalinovych, Jaroslava Nováková et autres

Non-stoichiometric nano-CeO 2 shows peroxidase activity both in flask and in vitro ; under Fenton-like conditions the effect is reversed: pro-oxidant in flask and protective in vitro . The addition of nano-Pt to CeO 2 enhances the effects in all cases.

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Prevention of Pseudomonas aeruginosa biofilm formation by pyocins

O.B. Bаlko, O. I. Balko, Zholobak Nm, L.V. Avdeeva

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A study on the interaction of gold nanoparticles with sodium sulfacetamide

V. I. Podolska, Л. С. Рєзніченко, L. N. Yakubenko, Т. Г. Грузина et autres

The present research is devoted to the investigation of a nanosystem including gold nanoparticles in an aqueous solution of sodium sulfacetamide in order to determine the nature and efficiency of their interaction depending on the concentration and pH of the medium. Sodium …

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In vitro and in vivo study of the biocompatibility and adjacent soft tissue response to synthetic polyvinyl formal hydrogel implant

Yu. M. Samchenko, S. М. Dybkova, A. Maletskyi, Liudmyla Kernosenko et autres

Background: Given a rising tendency in the rate of ocular trauma, there is an increasing need in surgeries for orbital, ocular adnexal and periorbital reconstruction. The susceptibility to resorption is a common drawback of the biological tissues used as a plastic material …

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Біологічна ефективність колоїдного (нанорозмірного) діоксиду церію у бджіл Apis mellifera

Л. М. Нікітіна, Д. А. Засєкін, Zholobak Nm, Т. М. ЄФІМЕНКО et autres

У роботі наведено результати експериментальних досліджень з визначення біологічної дії для бджіл за умови перорального та контактного потрапляння в їх організм колоїдного (нанорозмірного) церію діоксиду (нано-СеО2). Дослідження проведені в ННЦ «Інститут бджільництва імені П. І. Прокоповича» на базі пасіки та в лабораторії …

The specificity of changes in key performance indicators of green algae of the family Scenedesmaceae under the influence of cerium

Larysa M. Cheban, Alexander B. Shcherbakov, Zholobak Nm, Mikhailo M. Marchenko

The effect of various concentrations (1 μM – 100 mM) of citrate-stabilized cerium dioxide nanoparticles or cerium ions (3+) on the biomass production of two species of unicellular green algae Desmodesmus armatus (Chod.) Hegew and Acutodesmus dimorphus (Turpin) Tsarenko was studied, the …

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Binding parameters and conjugation mechanisms in the solutions of BSA with antioxidant CeO2 nanoparticles

O. O. Honcharova, Oksana Petrivna Dmytrenko, A. I. Lesiuk, Mykola P. Kulish et autres

The study results of the interaction of bovine serum albumin (BSA) with cerium dioxide CeO2 nanoparticles in saline solution at different temperatures are presented. The static mechanism of fluorescence quenching of the solutions was established. The formation of BSA-CeO2 conjugates occurs under …

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THE INFLUENCE OF FEEDING THE PROBIOTIC “APINORMIN” AND NANOCERIUM ON THE INDICATORS OF LIFE DURATION OF BEES IN LABORATORY CONDITIONS

V. O. Postoienko, L. M. Nikitina, Zholobak Nm, D. A. ZASIEKIN et autres

За лабораторних умов визначено вплив препарату «Апінормін», 4%, активованого нано-СеО2 (1мМ) чи активованого водою з подальшим додаванням нано-СеО2 (1мМ), на показники тривалості життя бджіл. Встановлено, що поєднання препарату «Апінормін» і водного золю нано-СеО2 у застосованих концентраціях (100 мл 50% цукрового сиропу – …

Preparation, properties and application of cerium(III) methanesulfonate

V.G. Vereshchak, Маргарита Скіба, O.S. Baskevich, Zholobak Nm

Based on the results of physicochemical analysis, IR-spectroscopy, derivatographic analysis and differential scanning calorimetry, it was established that the interaction of cerium(III) carbonate with methanesulfonic acid yields cerium(III) methanesulfonate Се(SO3CH3)34H2O. Thermolysis of complex compound Се(SO3CH3)34H2O proceeds via a complex chemical mechanism and …