Eduard Jáné

Protein corona modulates extracellular-vesicle recognition at glycan-based nanobiointerfaces

Tomáš Bertók, Eduard Jáné, Veronika Solovicová, Veronika Gajdošová et autres

Precise surface engineering is essential for robust characterization of extracellular vesicles and their interactions with biologically relevant interfaces. In this study, Au substrates were modified with C6 self-assembled monolayers (SAMs) bearing different terminal groups after multiple cleaning protocols to optimize monolayer compactness …

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Sugar-Coded Signals: Glycan-Based Biomarkers in Rheumatoid Arthritis

Michal Híreš, Štefánia Hrončeková, Viera Dujnič, Veronika Vrablova et autres

This review paper summarizes the pathophysiology of rheumatoid arthritis (RA), its incidence and etiology, and conventional RA protein-based biomarkers. A brief overview of novel protein-based biomarkers and biomarkers with potential to be used in the diagnostics of seronegative RA is also provided. …

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Glycoproteomics of Gastrointestinal Cancers and Its Use in Clinical Diagnostics

Tomáš Bertók, Andrea Pinkeová, Lenka Lorencová, Anna Ďatková et autres

High Resolution Image Download MS PowerPoint Slide Cancer is a leading cause of death worldwide, resulting in substantial economic costs. Because cancer is a complex, heterogeneous group of diseases affecting a variety of cells, its detection may sometimes be difficult. Herein we …

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Biomarker discovery based on advanced statistical methods. Analysis of N-glycome in plasma of colorectal cancer patients using MALDI-TOF MS analysis

Juvissan Aguedo, Eduard Jáné, Marek Nemčovič, Zuzana Pakanová et autres

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N-Acetylated Monosaccharides and Derived Glycan Structures Occurring in N- and O-Glycans During Prostate Cancer Development

Tomáš Bertók, Eduard Jáné, Michal Híreš, Jan Tkáč

Post-translational modifications of proteins play an important role in their stability, solubility and in vivo function. Also, for several reasons, such as the Golgi fragmentation during cancerogenesis, glycosylation as the most common modification is especially promising in offering high cancer specificity which, …

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Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches

Andrea Pinkeová, Natália Košútová, Eduard Jáné, Lenka Lorencová et autres

This review briefly introduces readers to an area where glycomics meets modern oncodiagnostics with a focus on the analysis of sialic acid (Neu5Ac)-terminated structures. We present the biochemical perspective of aberrant sialylation during tumourigenesis and its significance, as well as an analytical …

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Glycoprofiling of proteins as prostate cancer biomarkers: A multinational population study

Andrea Pinkeová, Adela Tomikova, Anikó Bertóková, Eva Fabinyova et autres

The glycoprofiling of two proteins, the free form of the prostate-specific antigen (fPSA) and zinc-α-2-glycoprotein (ZA2G), was assessed to determine their suitability as prostate cancer (PCa) biomarkers. The glycoprofiling of proteins was performed by analysing changes in the glycan composition on fPSA …

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Negative Charge-Carrying Glycans Attached to Exosomes as Novel Liquid Biopsy Marker

Natália Košútová, Lenka Lorencová, Michal Híreš, Eduard Jáné et autres

Prostate cancer (PCa) is the second most common cancer. In this paper, the isolation and properties of exosomes as potential novel liquid biopsy markers for early PCa liquid biopsy diagnosis are investigated using two prostate human cell lines, i.e., benign (control) cell …

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Glycoprofiling of proteins as prostate cancer biomarkers: a multinational population study

Andrea Pinkeová, Adela Tomikova, Anikó Bertóková, Eva Fabinyova et autres

Abstract The glycoprofiling of two proteins, the free form of the prostate-specific antigen (fPSA) and zinc-α-2-glycoprotein (ZA2G), was assessed to determine their suitability as prostate cancer (PCa) biomarkers. The glycoprofiling of proteins was performed by analysing changes in the glycan composition on …

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A Holistic 4D Approach to Optimize Intrinsic and Extrinsic Factors Contributing to Variability in Microarray Biosensing in Glycomics

Paras H. Kundalia, Lucia Pažitná, Kristína Kianičková, Eduard Jáné et autres

Protein-carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-throughput manner. The precise recognition of target glycan ligands …

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Amperometric Miniaturised Portable Enzymatic Nanobiosensor for the Ultrasensitive Analysis of a Prostate Cancer Biomarker

Štefánia Hrončeková, Lenka Lorencová, Tomáš Bertók, Michal Híreš et autres

Screen-printing technology is a game changer in many fields including electrochemical biosensing. Two-dimensional nanomaterial MXene Ti3C2Tx was integrated as a nanoplatform to immobilise enzyme sarcosine oxidase (SOx) onto the interface of screen-printed carbon electrodes (SPCEs). A miniaturised, portable, and cost-effective nanobiosensor was …

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Differentiating hydrous and anhydrous carbonaceous chondrites by secondary ion mass spectrometry

Justina Novakova, Eduard Jáné, Vojtech Szoecs, Monika Jerigová et autres

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