Gonzalo Herradón

Deletion of Pleiotrophin protects against high-fat diet-induced liver metabolic disease, independently of the sexual dimorphism in dietary response

Héctor Cañeque‐Rufo, Agata Zuccaro, Marta Inmaculada Sanz-Cuadrado, Federica Ruin et autres

Abstract Obesity is a global health problem linked to the development of metabolic syndrome and comorbidities such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Pleiotrophin (PTN) is a cytokine known for its role in tissue regeneration and …

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Circulating Brevican and Neurocan Are Reduced in Alcohol Use Disorder: A Peripheral Signature of Perineuronal Nets Alterations

Gonzalo Herradón, Elisa Rivera-Illades, María Flores-López, Esther Gramage et autres

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Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance

Teresa Fontán‐Baselga, Héctor Cañeque‐Rufo, Elisa Rivera-Illades, Esther Gramage et autres

Alzheimer’s disease (AD) is the most common cause of dementia. Pleiotrophin (PTN) is a neurotrophic factor relevant for central nervous system repair, neuron differentiation and survival. It is upregulated in different neuroinflammatory conditions. PTN is an endogenous inhibitor of Receptor Protein Tyrosine …

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Estudio de la ruta neurotrófica Pleiotrofina/PTPRZ en el hipocampo de ratas expuestas a consumo crónico de alcohol y/o deficiencia de tiamina

Rosario López‐Rodríguez, Marta Moya, Esther Gramage, Gonzalo Herradón et autres

Wernicke's encephalopathy (WE) is caused by thiamine deficiency (TD) whose main risk factor is alcohol use disorder. Pathogenic mechanisms associated with WE include mitochondrial dysfunction, oxidative stress and neuroinflammation. This study aims to explore the gene expression signature of certain candidate genes …

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Targeting Pleiotrophin to mitigate high fat diet-induced liver metabolic disease: Insights into sex-specific metabolic protection

Héctor Cañeque‐Rufo, Agata Zuccaro, Marta Inmaculada Sanz-Cuadrado, Federica Ruin et autres

ABSTRACT Obesity is a global health problem linked to the development of metabolic syndrome (MetS) and comorbidities such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). These diseases are characterised by systemic inflammation, lipid accumulation and tissue damage, …

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Pleiotrophin and receptor protein tyrosine phosphatase β/ζ as key modulators of high-fat diet-induced cognitive impairment and brain alterations

Héctor Cañeque‐Rufo, Teresa Fontán‐Baselga, Elisa Rivera-Illades, Marta Vicente‐Rodríguez et autres

) mice. To investigate the role of RPTPβ/ζ, we administered the selective inhibitor of RPTPβ/ζ, MY10, while mice were fed with HFD. The data demonstrate that Ptn deletion protects against both HFD-induced obesity and HFD-induced memory loss, whereas pharmacological inhibition of RPTPβ/ζ …

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Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions

María Aránzazu Penedo, Héctor Cañeque‐Rufo, Esther Gramage, Gonzalo Herradón

Microglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors. Recently, the signaling pathway initiated by the interaction of the neurotrophic factors pleiotrophin (PTN) and midkine (MK) with receptor-type protein tyrosine phosphatase β/ζ …

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Intermittent and limited exposure to a high-fat diet prevents social defeat-induced increase in ethanol intake and neuroinflammation

M. Carmen Arenas, Irene Pérez-Esteban, Héctor Cañeque‐Rufo, Esther Gramage et autres

Social stress is widely recognized for increasing ethanol consumption, an effect mediated by an enhanced neuroinflammatory response. High-fat diets (HFDs) alleviate stress and have been shown to reduce cocaine-seeking behavior, likely by serving as an alternative reinforcer. This study examines whether intermittent …

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Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

Héctor Cañeque‐Rufo, Teresa Fontán‐Baselga, Milagros Galán‐Llario, Agata Zuccaro et autres

Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. Pleiotrophin (PTN) is a cytokine that regulates energy metabolism and high-fat diet (HFD)-induced neuroinflammation, suggesting …

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Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice

Teresa Fontán‐Baselga, Héctor Cañeque‐Rufo, Elisa Rivera-Illades, Esther Gramage et autres

Alzheimer’s disease (AD) is a major neurodegenerative disorder that courses with chronic neuroinflammation. Pleiotrophin (PTN) is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ which is upregulated in different neuroinflammatory disorders of diverse origin, including AD. To investigate the role …

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Pleiotrophin Overexpression Reduces Adolescent Ethanol Consumption and Modulates Ethanol‐Induced Glial Responses and Changes in the Perineuronal Nets in the Mouse Hippocampus

Milagros Galán‐Llario, María Rodríguez‐Zapata, Teresa Fontán‐Baselga, Héctor Cañeque‐Rufo et autres

AIMS: To investigate whether pleiotrophin (PTN) overexpression influences ethanol consumption during adolescence and its effects on glial responses, neurogenesis, and perineuronal nets (PNNs) in the mouse hippocampus. METHODS: Male and female adolescent transgenic mice with elevated PTN levels (Ptn-Tg) and controls underwent …

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Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice

Cristina Ballesteros-Pla, Julio Sevillano, María Gracia Sánchez‐Alonso, María Limones et autres

Pleiotrophin (PTN) is crucial for embryonic development and pancreas organogenesis as it regulates metainflammation, metabolic homeostasis, thermogenesis, and glucose tolerance. Pleiotrophin deletion is associated with a lipodystrophic phenotype in which adipose tissue plasticity is altered in late life. This study explored the …

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