Accès ouvert
2026
article
OpenAlex
Farhan H. Khan, Christoph Stretz, Skylar Lewis, Dalia Chahien et autres
BACKGROUND: Although the embolic stroke of undetermined source (ESUS) construct was proposed as a unifying concept for embolic-appearing strokes without an identified cause, it includes patients with diverse and often unrecognized underlying mechanisms. This study investigates the differential rate of recurrent stroke …
us
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2026
article
OpenAlex
Mahan Shahrivari, James Charles Grotta
Intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) are the keystones of current treatment for acute ischemic stroke. Most IVT candidates harbor medium or distal arterial occlusions, while EVT targets large artery occlusions. However, both treatments often fail to achieve sustained recanalization, microvascular …
us
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Accès ouvert
2026
article
OpenAlex
Hassan Aboul Nour, James Ernest Siegler, Sean L. Thompson, Patrick A. Glover et autres
BACKGROUND AND OBJECTIVES: Multiple clinical trials have failed to show benefit of anticoagulation over antiplatelets in preventing recurrent stroke among patients with embolic stroke of undetermined source (ESUS). However, there are limited data on antithrombotic prescribing patterns and clinical outcomes in a …
us
(code pays fourni par la source)
2026
article
OpenAlex
Richa Sharma, Katelyn F. McNamara, Elena Badillo Goicoechea, Anna Bowman et autres
BACKGROUND: Left ventricular (LV) dysfunction is a potential cardioembolic source of ischemic stroke, but its role in recurrent stroke risk and treatment response remains unclear. We explore whether LV injury associates with the risk of recurrent stroke and modifies the association between …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Anvesh A. Balabhadra, Arash Niktabe, Joseph N. Samaha, Ngoc Mai Le et autres
Background: Endovascular Thrombectomy (EVT) improves outcomes in patients with large core acute ischemic stroke, but identifying patients who benefit remains a challenge. Here, we study whether pre-procedure CTA collateral scoring successfully classifies treatment benefit. Methods: We analyzed consecutive patients from the prospectively …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Elena Badillo Goicoechea, James Ernest Siegler, Christina M. Lineback, Frank Conyers et autres
Introduction: Embolic stroke of undetermined source (ESUS) is a clinical construct encompassing heterogenous possible mechanisms of incident stroke, potentially with variable responsiveness to anticoagulation and antiplatelet treatment. This study aims to identify differences in recurrent stroke risk based on phenotypic clusters in …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Fahad Khan, Christoph Stretz, Skylar Lewis, Dalia Chahien et autres
Background: Although the embolic stroke of undetermined source (ESUS) construct was proposed as a unifying concept for embolic-appearing strokes without an identified cause, it includes patients with diverse and often unrecognized underlying mechanisms. This study investigates the differential rate of recurrent stroke …
us, ie
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Farid Khasiyev, Alireza Borghei, Marissa D'Souza, Christina M. Lineback et autres
Background: Embolic stroke of undetermined source (ESUS) comprises infarct mechanisms presumed to be embolic and non-lacunar. One explanation for the lack of superiority of anticoagulation over aspirin is the inclusion of subcortical infarcts with white matter disease (WMD), reflecting small vessel pathology. …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
T.K. Garrett, Shivika Chandra, Sushanth Aroor, Cristy Autry et autres
Background and Objectives: Emergency medical services (EMS) clinicians play a critical role in early identification and management of neurologic emergencies yet may encounter sparse neurology-specific education. With interprofessional collaboration, we developed a multimodal, active-learning, and experiential curriculum for teaching prehospital care in …
us
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Accès ouvert
2025
article
OpenAlex
Matthew M. Smith, James R. Brorson, Elena Badillo‐Goicoechea, Mary Penckofer et autres
BACKGROUND: Intracranial occlusions in embolic stroke of undetermined source are histopathologically similar to cardiac sources of embolism. Whether patients with embolic stroke of undetermined source and intracranial occlusion benefit from anticoagulation is unknown. METHODS: A multicenter retrospective cohort of adults with cryptogenic …
us, gb
(code pays fourni par la source)
2025
article
OpenAlex
James Ernest Siegler, Elena Badillo‐Goicoechea, Mary Penckofer, Kelsey Eklund et autres
BACKGROUND AND OBJECTIVES: Embolic stroke of undetermined source (ESUS) can be attributed to a variety of potential embolic sources, with differential response to anticoagulation. METHODS: A multicenter, retrospective observational cohort study (27 sites) of consecutive adult patients with acute ischemic stroke due …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Hassan Aboul Nour, Sean L. Thompson, Patrick A. Glover, Shadi Yaghi et autres
Background: Multiple randomized clinical trials failed to show benefit of anticoagulation over antiplatelets in the secondary prevention for embolic stroke of undetermined source (ESUS). However, the benefit of combination antithrombotic regimens remains unexplored in the same patient population. Methods: This is a …
us, ie
(code pays fourni par la source)