Alexandra Hübner

A synthetic genomics-based African swine fever virus engineering platform

Walter Fuchs, Nacyra Assad-Garcia, Hussein M. Abkallo, Yong Xue et autres

African swine fever (ASF) is a deadly viral disease in domestic pigs that has a large global economic impact for the swine industry. It is present in Africa, Europe, Asia, and in the Caribbean island of Hispaniola. There are no effective treatments …

de, us, Kenya, Ouganda (code pays fourni par la source)

A Deep-Sequencing Workflow for the Fast and Efficient Generation of High-Quality African Swine Fever Virus Whole-Genome Sequences

Jan H. Forth, Leonie F. Forth, Jacqueline King, Oxana Groza et autres

African swine fever (ASF) is a severe disease of suids caused by African swine fever virus (ASFV). Its dsDNA genome (170-194 kbp) is scattered with homopolymers and repeats as well as inverted-terminal-repeats (ITR), which hamper whole-genome sequencing. To date, only a few …

de, dk, gb (code pays fourni par la source)

Detection of Two Highly Diverse Peribunyaviruses in Mosquitoes from Palenque, Mexico

Anne Kopp, Alexandra Hübner, Florian Zirkel, Daniel Hobelsberger et autres

. Orthobunyaviruses and pacuviruses are mainly transmitted by blood-feeding insects and infect a variety of vertebrates whereas herbeviruses and shangaviruses have a host range restricted to insects. Here, we tested mosquitoes from a tropical rainforest in Mexico for infections with peribunyaviruses. We …

de, mx, us (code pays fourni par la source)

Expression of African swine fever virus proteins in a liveattenuated pseudorabies virus vector

Katrin Pannhorst, Alexandra Hübner, Jolene Carlson, Tonny Kabuuka et autres

Identification and characterization of the 285L and K145R proteins of African swine fever virus

Alexandra Hübner, Catharina Keßler, Katrin Pannhorst, Jan H. Forth et autres

African swine fever (ASF) is a lethal disease of domestic pigs and wild boar, against which no vaccines are available to date. The large dsDNA genome of African swine fever virus (ASFV) contains up to 167 ORFs predicted to encode proteins. The …

de (code pays fourni par la source)

Schweinepestdiagnostik: Nachweisbarkeit viraler RNA und der internen Kontrolle in verschiedenen Probenmatrizes

Jutta Pikado, Robin C. Brandt, Ulrike Kleinert, Sandra Blome et autres

Efficient transgene insertion in a pseudorabies virus vector by CRISPR/Cas9 and marker rescue-enforced recombination

Alexandra Hübner, Günther M. Keil, Tonny Kabuuka, Thomas C. Mettenleiter et autres

de (code pays fourni par la source)

Efficient inhibition of African swine fever virus replication by CRISPR/Cas9 targeting of the viral p30 gene (CP204L)

Alexandra Hübner, Björn Petersen, Günther M. Keil, Heiner Niemann et autres

African swine fever is a devastating viral disease of domestic and wild pigs against which no vaccine or therapy is available. Therefore, we applied the CRISPR (clustered regularly interspaced short palindromic repeats) - Cas9 nuclease system to target the double-stranded DNA genome …

de (code pays fourni par la source)

Expression of African swine fever virus proteins by a pseudorabies virus vector

Alexandra Hübner, W. H. Fuchs, Günther M. Keil, Sandra Blome et autres

Discovery of novel bunyaviruses in mosquitoes from the neotropics

Anne Kopp, Florian Zirkel, Alexandra Hübner, Daniel Hobelsberger et autres