Sibylle Ohl

Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL

Lavinia Arseni, Gianluca Sigismondo, Haniyeh Yazdanparast, Johanne Uthus Hermansen et autres

Chronic lymphocytic leukemia is a malignant lymphoproliferative disorder for which primary or acquired drug resistance represents a major challenge. To investigate the underlying molecular mechanisms, we generate a mouse model of ibrutinib resistance, in which, after initial treatment response, relapse under therapy …

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Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression

Lavinia Arseni, Rakesh Kumar Sharma, Norman L. Mack, Deepthi Nagalla et autres

Glioblastoma is the most aggressive brain tumor in adults. Treatment failure is predominantly caused by its high invasiveness and its ability to induce a supportive microenvironment. As part of this, a major role for tumor-associated macrophages/microglia (TAMs) in glioblastoma development was recognized. …

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Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues

Marie Bordas, Géraldine C. Genard, Sibylle Ohl, Michelle Neßling et autres

Small extracellular vesicles (sEVs) are nanoparticles responsible for cell-to-cell communication released by healthy and cancer cells. Different roles have been described for sEVs in physiological and pathological contexts, including acceleration of tissue regeneration, modulation of tumor microenvironment, or premetastatic niche formation, and …

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Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia

Lena Schulze-Edinghausen, Claudia Dürr, Selcen Öztürk, Manuela Zucknick et autres

Chronic lymphocytic leukemia (CLL) is known for its strong dependency on the tumor microenvironment. We found progranulin (GRN), a protein that has been linked to inflammation and cancer, to be upregulated in the serum of CLL patients compared to healthy controls, and …

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Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne McClanahan Lucas et autres

Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247 chronic lymphocytic leukemia serum samples revealed …

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Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton

Peter Boldsen Knudsen, Bola S. Hanna, Sibylle Ohl, Leopold Sellner et autres

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Microenvironmental Factors and The Role Of Tumor Necrosis Factor Receptor Type 1 (TNFR-1) In Chronic Lymphocytic Leukemia

Claudia U. Duerr, Angela Schulz, Sibylle Ohl, Thorsten Zenz et autres

Abstract B-cell Chronic Lymphocytic Leukemia (CLL) represents the most common leukemia among adults in the western world and remains still incurable. CLL is characterized by the accumulation of malignant B-cells in the peripheral blood and the lymphoid organs due to apoptosis resistance. …

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Soluble CD14 is a novel monocyte-derived survival factor for chronic lymphocytic leukemia cells, which is induced by CLL cells in vitro and present at abnormally high levels in vivo

Martina Seiffert, Angela Schulz, Sibylle Ohl, Hartmut Döhner et autres

Accumulation of leukemic cells in patients with chronic lymphocytic leukemia (CLL) is due to prolonged cell survival rather than increased proliferation. Survival of CLL cells depends on microenvironmental factors. Even though long-lived in vivo, CLL cells rapidly die by spontaneous apoptosis in …

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Treatment of Hairy-Cell Leukemia with Recombinant Leukocyte A Interferon

H. K. Mahmoud, Sibylle Ohl, UW Schaefer, Dietrich Wilhelm Beelen et autres

A 29-year-old male patient with hairy-cell leukemia was referred for bone marrow transplantation. For tumor mass reduction a treatment with recombinant leucocyte A interferon was started. A complete remission could be achieved in the third month of treatment and no adverse side …

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Neuigkeiten für die klinische Praxis

S. Seeber, Winfried Gassmann, Nicole Schmitz, P. Meusers et autres

Inhalt, Vol. 8, No. 3, 1985

H. K. Mahmoud, U.W. Schaefer, D. Beelen, H. Grosse‐Wilde et autres

Onkologie-Mitteilungen

S. Seeber, Winfried Gassmann, Nicole Schmitz, P. Meusers et autres